Cemalettin Çelebi

Facial resurfacing in Xeroderma pigmentosum with monoblock full-thickness skin graft

A case of xeroderma pigmentosum with multiple skin tumors on the face that was treated with total excision and replacement of face skin except the eyelids with a monoblock full-thickness abdominal skin graft is reported. The quality and tumor-free features of the monoblock full-thickness skin graft in xeroderma pigmentosum are indicated. Despite the increased morbidity of the donor region, the radical surgical approach advocated here has improved the prognosis in the case reported.

Proper timing of breast reduction during the menstrual cycle.

Breasts are known to show cyclic changes in accordance with the menstrual cycle, and speculations have been made regarding the ideal timing of breast surgery in this extent, but the clinical evidence to support global acceptance and application is lacking. This study was designed to establish the relationship of intraoperative bleeding and postoperative drainage with the menstrual period of 35 reduction mammaplasty patients. The results indicate that both perioperative blood loss and postoperative drainage were significantly reduced when breast reduction is performed during the periovulatory phase compared with the perimenstrual phase. The authors strongly recommend the interval between days 8 and 20 of the menstrual cycle as a more convenient period to perform breast reduction. Drains may be avoided during this period, but they are preferred if the surgery is done during the perimenstrual phase.

Feasibility of demineralized bone matrix for craniomaxillofacial contour restoration.

Demineralized bone matrix (DBM) could be a good alternative for craniomaxillofacial contour restoration, especially in perialar, malar, temporal, and frontal regions. In this study, the histologic behavior of DBM was investigated in different tissue planes to determine its proper application plane for restoration of craniomaxillofacial contour deformities and defects. Forty Wistar rats were divided into 6 groups: (1) 0.3 mL of 0.9% saline was injected into the subperiosteal plane of the cranium, (2) 0.3 mL of DBM was implanted into the subperiosteal plane of the cranium, (3) 0.3 mL of 0.9% saline was injected into the subdermal plane on the left inguinal region, (4) 0.3 mL of DBM was implanted into the subdermal plane on the right inguinal region, (5) 0.3 mL of 0.9% saline was injected between the left external and internal oblique muscles, and (6) 0.3 mL of DBM was implanted between the right external and internal oblique muscles. At the 8th week half of the rats and at 16th week the remaining rats were killed in each group, and tissue samples were harvested. Histological and immunohistochemical evaluation revealed new bone tissue and bone marrow formation in all planes that DBM was given. Demineralized bone matrix can provide satisfactory results in craniomaxillofacial contour deformities including forehead, temporal, and malar augmentations, as well as mental and perialar augmentations and saddle nose corrections, with supraperiosteal or deep subcutaneous applications. However, superficial applications must be avoided because of the possibility of palpation, because it induces hard bone tissue formation in all tissue planes.

A twelve year experience with reduction mammoplasty and abdominoplasty

In the last 12 years we performed mammoplasty on 191 patients, using the Wise pattern and the Strömbeck technique. In the same 12-year period, we also performed abdominoplasty in 108 patients, using the Pitanguy and the Grazer procedures. In the last four years we performed suction lipectomy in 43 patients, using the Illouz technique. In this article we present our moderate modifications on these techniques and the complications.

Vulva reconstruction with a tissue expander.

A patient with exstrophy of the bladder in whom we performed vulva reconstruction using a tissue-expansion technique and local flaps was presented. The ultimate result was in concert with the anatomic characteristics of normal external genitalia with regard to type of skin, pigmentation, hair pattern, quality of circulation, and sensory supply.

Effects of Rat Bone Marrow-Derived Mesenchymal Stem Cells and Demineralized Bone Matrix on Cranial Bone Healing.

BackgroundStudies in tissue engineering about mesenchymal stem cells (MSCs) provide promising results for bone regeneration. The aim of this study was to evaluate the effects of rat bone marrow–derived MSCs (rMSCs) alone and when combined with demineralized bone matrix (DBM) on critical-sized cranial defects of rats. MethodsTen rats were used to obtain allogeneic rMSCs. Forty rats were separated equally into 4 groups. A full-thickness circular bone defect was created in the frontal bone of the rats. Group 1 was an operative control group. In group 2 DBM, in group 3 rMSCs, and in group 4 DBM combined with rMSCs were applied into the defects. Bone regeneration was evaluated by computed tomographic analysis and immunohistochemistry. ResultsIn radiological evaluation, the percentage of area healed in group 3 at the 12th week was statistically significantly greater than in group 1. In group 3 and group 4, distributed healing patterns were observed more than in group 2 and in group 1. Immunohistochemical evaluation revealed that group 4 had the best osteoinductive potential. Osteoinductive potential of group 3 was similar to group 2 and was better than group 1. ConclusionsAllogeneic rMSC applications have created a statistically significant radiologic reduction of the bone defect areas at the end of the 12 weeks. The MSC applications have also increased the bone density and changed the healing patterns. Combined use of the DBM and rMSCs has created more osteoinductive responses. This combination can provide better results in craniofacial bone reconstruction.

ELEVATION OF DEEPLY LOCATED VASCULAR STRUCTURES IN ORDER TO FACILITATE END-TO-SIDE ANASTOMOSIS

This paper presents a simple method of carrying deeply located recipient vascular structures to the surface in order to facilitate end-to-side anastomoses in free-flap transplantations.

The Feasibility of Demineralized Bone Matrix for Craniofacial Contour Restoration: An Experimental Study

www.PRSJournal.com 131 Scntific Psters CONCLUSION: Subcellular localization using the subcellular AQUA ratio of HMB45 and NEDD9 defines nevi from melanoma on TMA but is not useful in discriminating between Spitz nevi and melanoma with Spitzoid features. The maximum HMB45 AQUA score of a whole tissue section was promising on discovery analysis at differentiating between Spitz nevi and melanoma with Spitzoid features (p=0.007, ROC area 0.711) but requires validation on an independent cohort.

Giant pilar tumor of the scalp.

SACLI DERININ DEV PILAR TUMORU. Ingilizce literaturde bugune kadar bildirilen pilar tumorlerin hepsinden daha buyuk hacimli dev bir scalp pilar tumoru sunulmaktadir. Tumorun buyume ozelligi ve kalitim faktorunun boyle lezyonlardaki muhtemel rolu uzerinde durlmustur. Tedavide yeterli cerrahi eksizyonun ve titiz histopatolojik incelemenin onemi vurgulamistir.