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Featured researches published by Cengiz Taşçı.


Annals of Nuclear Medicine | 2002

Technetium-99m human immunoglobulin scintigraphy in patients with adhesive capsulitis : A correlative study with bone scintigraphy

Ozlem Senocak; Berna Degirmenci; Ozhan Ozdogan; Elif Akalin; Gulhan Arslan; Burcu Kaner; Cengiz Taşçı; Özlen Peker

Adhesive capsulitis (AC) is a disorder that is characterized by shoulder pain and progressive limitation of both active and passive shoulder motion. Although the underlying pathological mechanisms of the disease are not well understood, the inflammatory reactions depending on the stage have been demonstrated histologically. The purpose of the study is to investigate the inflammatory changes that can be demonstrated with Tc-99m HIG in AC, and to determine the presence of correlations between scintigraphic findings and the clinical assessment. Twenty-one patients (12 females and 9 males) with a mean age of 50.57±8.49 were included in the study. AC was diagnosed according to recognized criteria. The planar X-ray images of the affected shoulders of all patients were normal. The patients were evaluated with the Constant Scoring System, and the functional and pain assessment parts of the American Shoulder and Elbow Surgeons’ Form (ASES). Three phase bone scans and Tc-99m HIG scintigraphy were performed at least two days apart. Bone scan and Tc-99m HIG scintigraphy were evaluated visually and HIG uptake was evaluated in comparison with the contralateral normal shoulder. Bone scan demonstrated hypervascularity in 9 of the 21 patients (43%), whereas increased osteoblastic activity was detected in 19 (90%) in the affected shoulder. Tc-99m HIG uptake was positive in 12 (57%), and negative in 9 (43%) patiens. All patients with increased Tc-99m HIG accumulation in the affected shoulder, also had increased osteoblastic activity on Tc-99m bone scintigraphy. A significant correlation was found between HIG uptake and constant, functional and pain scores. The difference between these scores was also statistically significant in patients with HIG positive and negative uptake. This study indicates that there is a good correlation between Tc-99m HIG scan findings and clinical scores. Tc-99m HIG accumulation in the affected shoulder may be related to continuing inflammatory reaction to AC. Tc-99m HIG scan may be a noninvasive, complementary method for demonstrating continuing inflammatory changes and may help in staging the disease.


Lung | 2006

Technetium-99m Hexamethylpropylene Amine Oxime Lung Scintigraphy Findings in Low-Dose Amiodarone Therapy

G. Capa Kaya; Türkan Ertay; Burçin Tuna; Recep Bekis; Cengiz Taşçı; Elvan Sayit; Osman Yilmaz; Aydanur Kargi; Hatice Durak

Amiodarone (AD)-induced pulmonary toxicity is one of the major complications of long-term AD therapy. Technetium-99m-labeled D,L-hexamethylpropylene amine oxime (Tc-99m HMPAO) scintigraphy has been used to assess lung injury. We designed this study to clarify lung uptake changes of Tc-99m HMPAO using low doses of AD (5 mg/kg/day) during long-term therapy in a rabbit model. Group 1 consisted of 7 rabbits fed with AD by gavage for 6 months. To investigate the effect of ketamine on Tc-99m HMPAO uptake, 5 rabbits were included in Group 2 as a control group. Tc-99m HMPAO scintigraphy was performed in both Group 1 and Group 2 at baseline and after 2, 4, 6, 8, and 12 weeks of AD intake. After 16, 20, and 24 weeks of drug intake, Tc-99m HMPAO scintigraphy was repeated only in group 1. One-min anterior images were acquired 30 min after the injection of 37 MBq of Tc-99m HMPAO. For semiquantitative evaluation, the mean count values were obtained and lung/background and liver/background ratios were calculated. Histopathologic evaluation was performed. No increase in lung and liver uptake of Tc-99m HMPAO was found 2, 4, 6, 8, and 12 weeks after drug intake. There was no significant increase in L/B and H/B ratios of Tc-99m HMPAO in Group 1 compared with Group 2. Both scintigraphic studies and histopathologic examinations showed nonspecific changes. Longitudinal studies investigating Tc-99m HMPAO lung uptake may be planned in patients carrying risk factors for AD-induced lung toxicity.


Molecular Imaging and Radionuclide Therapy | 2011

Tc-99m HIG Scintigraphy in Detection of Active Inflammation in Ankylosing Spondylitis

Ozhan Ozdogan; Berna Degirmenci; Özlem Şenocak; Selmin Gulbahar; Gulhan Arslan; Cengiz Taşçı; Elif Akalin; Hatice Durak

Objective: The diagnosis of active inflammation in ankylosing spondylitis (AS) is crucial for treatment to delay possible persistent deformities. There are no specific laboratory tests and imaging methods to clarify the active disease. We evaluated the value of Tc-99m human immunoglobulin (HIG) scintigraphy in detection of active inflammation. Material and Methods: Twenty-nine patients were included. Tc-99m methylenediphosphonate bone (MDP) and HIG scintigraphies were performed within 2-5 day intervals. Two control groups were constituted both for MDP and HIG scintigraphies. Active inflammation was determined clinically and by serologic tests. Both scintigraphies were evaluated visually. Sacroiliac joint index values (SII) were calculated. Results: Active inflammation was considered in five (sacroiliitis in 2, sacroiliitis-spinal inflammation in 1, achilles tendinitis in 1, arthritis of coxafemoral joints in 1) patients. HIG scintigraphy demonstrated active disease in all 3 patients with active sacroiliitis. But, it was negative in the rest. The other 2 active cases were HIG negative. Right and left SII obtained from HIG scintigraphy was higher (p<0.05) in clinically active patients than inactive patients. There was not any significant difference between patients with inactive sacroiliitis and normal controls. Right and left SII obtained from bone scintigraphy was higher (p<0.05) in patient group than in control group. Conclusion: Clinically inactive AS patients, behave no differently than normal controls with quantitative sacroiliac joint evaluation on HIG scintigraphy. HIG scintigraphy may be valuable for evaluation of sacroiliac joints in patients with uncResults:ertain laboratory and clinical findings. Conflict of interest:None declared.


Molecular Imaging and Radionuclide Therapy | 2013

The Evaluation Criteria in Diagnosing Ischemia with Stress and Rest Myocardial Perfusion Gated SPECT.

Cengiz Taşçı

Dear Editor, The study named “The role of myocardial perfusion gated SPECT study in women with coronary artery disease” reveals some current and important issues in diagnosing myocardial ischemia in women (1). Because the obesity is the highest and the death from coronary artery disease (CAD) is the second highest in Turkish women among all European countries, diagnosing CAD in women becomes much more important in daily cardiology and nuclear cardiology practice in our country. We have to pay more attention in clarifying the gender-related differences in nuclear cardiology. This study raises awareness about the issue. On the other hand the evaluation criterion for diagnosing ischemia seems controversial in the study. The question is that: “Do the left ventricular (LV) wall motion abnormality and decreased systolic thickening at the segment with reduced perfusion in gated SPECT study necessarily show true ischemia as it is expressed in the study? This approach considers that wall motion abnormality and perfusion defects occur exactly at the same time in CAD stages, but as it is known, wall motion abnormalities follow quite a bit later after the perfusion defects appear. Myocardial hypoperfusion is first seen in ischemic cascade, and followed by decrease in metabolic activity, relaxation impairment (diastolic dysfunction), reduction in contractility (systolic dysfunction), global LV dysfunction, ECG changes and angina pectoris, respectively (2). So, the evaluation criterion in the study is true for the advanced stages of ischemia, but not in the beginning of the disease. In the beginning, ischemia may be seen with completely normal wall motion and systolic thickening. So, the approach in the study neglects the ischemic patients with normal cardiac wall motions. More importantly, because the imaging begins 30-60 minutes after the radiopharmaceutical injection, stress–gated images with Tc-99m MIBI show stress perfusion at the time of injection, but LV function (wall motion, systolic thickening or ejection fraction) at the time of acquisition. Snapper et al. demonstrated that the combination of a perfusion defect with normal wall motion and thickening in the same segment on stress-gated MIBI images was associated with a high positive predictive value (96%) for detecting ischemia. They concluded that the diagnosis of ischemia could be made confidently in patients with normal wall thickening in a segment with perfusion defect. The lack of wall thickening was found less specific, because only 40% of the cases with perfusion defects and wall motion abnormalities showed reversibility on rest perfusion imaging (3,4). Actually, this conclusion is also not always true in daily nuclear cardiology practice, even if there is no soft tissue attenuation. This evaluation accepts that the time course of the resolution of ischemia-induced stunning and LV dysfunction ends immediately after completion of exercise or pharmacological stress. However, there is a lot of evidence demonstrating that the regional wall motion abnormalities persist for variable time periods lasting in seconds, 30 minutes or up to 2-6 hours associated with the severity of stress-induced ischemia. Relatively longer time periods of persistence is particularly due to the presence of repetitive stunning (5). Thus, the functional evaluation in Tc-99m MIBI stress-gated imaging sometimes shows rest situation with no or resolved myocardial wall motion abnormality in slight form of ischemia, and sometimes shows post-stress wall motion abnormalities persisting up to the time of acquisition in more severe forms. So, the term transient ischemic dilation (TID) gains importance defined as the difference between stress and rest end-systolic and end-diastolic volumes. The volumes are greater in post-stress imaging than those in rest imaging in patients with TID. Additionally, lower LV ejection fraction (LVEF) in stress imaging than in rest imaging indicates prolonged post-ischemic stunning and worse prognosis (5). Because of these reasons, LV functions found in rest echocardiography do not always correlate with the findings on post-stress gated SPECT imaging even when neglecting the problems originated from the technical differences. Finally, the criterion mentioned in the study could be entirely true and supporting if all the subjects had been shown to have reversible defect (ischemia), but some patients are reported to have myocardial infarction. So the criterion might include myocardial scar in patients with fix defect (particularly when the presence of metabolic activation on the defect related with hibernation was excluded). In the routine evaluation of gated SPECT studies, wall motion abnormality and/or systolic thickening at the same segment with fixed defect primarily indicates myocardial scar. So, the inclusion criterion that the authors used in the study constitutes a great limitation for drawing true conclusions about ischemia and/or infarct without making some comparisons between post-stress and rest end-systolic and end-diastolic volumes or measuring LVEF differences together with the wall motion abnormalities. The evaluation criteria to differentiate ischemia, infarct and soft tissue attenuation artifacts in stress-rest gated SPECT imaging may be simply summarized as below: 1. Normal perfusion with no wall motion abnormality or TID: Normal 2. Normal perfusion with wall motion abnormality or TID: Stunning (and/or multivessel disease?). 3. Reversible ischemia with no wall motion abnormality, TID or reduced LVEF in stress-gated images: Ischemia. 4. Reversible ischemia with wall motion abnormality, TID or reduced LVEF in stress-gated images: Severe ischemia with increased cardiac event rate. 5. Fixed defect with normal wall motion or wall thickening: Soft tissue attenuation artifact. 6. Fixed defect with wall motion or wall thickening abnormality: Myocardial scar.


Progress in Neuro-psychopharmacology & Biological Psychiatry | 2006

Effects of long-term methylphenidate treatment: A pilot follow-up clinical and SPECT study

Aynur Akay; Gamze Çapa Kaya; Neslihan İnal Emiroğlu; Aysel Aydin; E. Serap Monkul; Cengiz Taşçı; Süha Miral; Hatice Durak


Journal of Radioanalytical and Nuclear Chemistry | 2005

99mTc-exorphin C: A new peptide radiopharmaceutical for tumor imaging

Türkan Ertay; Perihan Unak; Cengiz Taşçı; F.Z. Biber; Figen Zihnioglu; Hatice Durak


Applied Radiation and Isotopes | 2007

Scintigraphic imaging with a peptide glucuronide in rabbits: 99mTc- exorphin C glucuronide

Türkan Ertay; Perihan Unak; F.Z. Biber; Cengiz Taşçı; Figen Zihnioglu; Hatice Durak


Applied Radiation and Isotopes | 2005

Scintigraphic imaging with 99mTc- exorphin C in rabbits

Türkan Ertay; Perihan Unak; Cengiz Taşçı; Figen Zihnioglu; Hatice Durak


Molecular Imaging and Radionuclide Therapy | 2011

An Overview on Coronary Heart Disease (A Comparative Evaluation of Turkey and Europe) and Cost-effectiveness of Diagnostic Strategies

Cengiz Taşçı; Nihat Özçelik


World Journal of Nuclear Science and Technology | 2015

Assessment of the Patient Movement for Lesion during Myocardial Perfusion SPECT Imaging by Cardiac Phantom

Eser Erim; Türkan Ertay; Ismail Evren; Mine Şencan Eren; Cengiz Taşçı; Hatice Durak

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Hatice Durak

Dokuz Eylül University

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Elif Akalin

Dokuz Eylül University

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F.Z. Biber

Dokuz Eylül University

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Osman Yilmaz

Dokuz Eylül University

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