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Chad E. Knutson

Schering-Plough

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Publication

Featured researches published by Chad E. Knutson.

ACS Medicinal Chemistry Letters | 2010

Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases

Kamil Paruch; Michael P. Dwyer; Carmen Alvarez; Courtney Brown; Tin-Yau Chan; Ronald J. Doll; Kerry Keertikar; Chad E. Knutson; Brian Mckittrick; Jocelyn Rivera; Randall R. Rossman; Greg Tucker; Thierry O. Fischmann; Alan Hruza; Vincent Madison; Amin A. Nomeir; Yaolin Wang; Paul Kirschmeier; Emma Lees; David Parry; Nicole Sgambellone; Wolfgang Seghezzi; Lesley Schultz; Frances Shanahan; Derek Wiswell; Xiaoying Xu; Quiao Zhou; Ray Anthony James; Vidyadhar M. Paradkar; Haengsoon Park

Inhibition of cyclin-dependent kinases (CDKs) has emerged as an attractive strategy for the development of novel oncology therapeutics. Herein is described the utilization of an in vivo screening approach with integrated efficacy and tolerability parameters to identify candidate CDK inhibitors with a suitable balance of activity and tolerability. This approach has resulted in the identification of SCH 727965, a potent and selective CDK inhibitor that is currently undergoing clinical evaluation.

Archive | 2003

Pyrazolopyrimidines as cyclin dependent kinase inhibitors

Timothy J. Guzi; Kamil Paruch; Michael P. Dwyer; Ronald J. Doll; Viyyoor M. Girijavallabhan; Chad E. Knutson; Brian Mckittrick; Lawrence W. Dillard; Vinh D. Tran; Zhen Min He; Ray Anthony James; Haengsoon Park

Archive | 2007

Azetidinone derivatives and methods of use thereof

Robert G. Aslanian; Chad E. Bennett; Duane A. Burnett; Tin-Yau Chan; Eugenia Y. Kiselgof; Chad E. Knutson; Joel M. Harris; Brian Mckittrick; Anandan Palani; Elizabeth M. Smith; Henry M. Vaccaro; Dong Xiao; Hyunjin M. Kim

Bioorganic & Medicinal Chemistry Letters | 2007

Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2

Kamil Paruch; Michael P. Dwyer; Carmen Alvarez; Courtney Brown; Tin-Yau Chan; Ronald J. Doll; Kerry Keertikar; Chad E. Knutson; Brian Mckittrick; Jocelyn Rivera; Randall R. Rossman; Greg Tucker; Thierry O. Fischmann; Alan Hruza; Vincent Madison; Amin A. Nomeir; Yaolin Wang; Emma Lees; David Parry; Nicole Sgambellone; Wolfgang Seghezzi; Lesley Schultz; Fran Shanahan; Derek Wiswell; Xiaoying Xu; Quiao Zhou; Ray Anthony James; Vidyadhar M. Paradkar; Haengsoon Park; Laura R. Rokosz

Archive | 2007

Spiro-condensed azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabilism

Brian Mckittrick; Elizabeth M. Smith; Chad E. Bennett; Joel M. Harris; Eugenia Y. Kiselgof; Chad E. Knutson; Peter Korakas; Deen Tulshian; Hyunjin M. Kim

Archive | 2007

Azetidinone derivatives for the treatment of disorders of the lipid metabolism

Robert G. Aslanian; Chad E. Bennett; Duane A. Burnett; Tin-Yau Chan; Eugenia Y. Kiselgof; Chad E. Knutson; Joel M. Harris; Kittrick Brian A. Mc; Anandan Palani; Elizabeth M. Smith; Henry M. Vaccaro; Dong Xiao; Hyunjin M. Kim

Archive | 2007

Azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabolism

Brian Mckittrick; Elizabeth M. Smith; Chad E. Bennett; Joel M. Harris; Eugenia Y. Kiselgof; Chad E. Knutson; Peter Korakas; Deen Tulshian; Hyunjin M. Kim

Archive | 2007

Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors

Theodros Asberom; Thomas Bara; Chad E. Bennett; Duane A. Burnett; Mary Ann Caplen; John W. Clader; David Cole; Martin Domalski; Hubert Josien; Chad E. Knutson; Hongmei Li; Mark D. McBriar; Dmitri A. Pissarnitski; Li Qiang; Murali Rajagopalan; Thavalakulamgar Sasikumar; Jing Su; Haiqun Tang; Wen-Lian Wu; Ruo Xu; Zhiqiang Zhao

Archive | 2006

Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors

Timothy J. Guzi; Kamil Paruch; Michael P. Dwyer; Ronald J. Doll; Viyyoor M. Girijavallabhan; Carmen Alvarez; Tin Yau Chan; Chad E. Knutson; Vincent Madison; Thierry O. Fischmann; Lawrence W. Dillard; Vinh D. Tran; Zhen Min He; Ray Anthony James; Haengsoon Park

Archive | 2006

Pyridothienopyridazinone derivatives as mGluR1 antagonists

Chad E. Bennett; William J. Greenlee; Chad E. Knutson; Duane A. Burnett

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Chad E. Bennett

Merck

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Tin-Yau Chan

Schering-Plough

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Haengsoon Park

Ohio State University

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Michael P. Dwyer

Merck

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Ray Anthony James

Schering-Plough

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Ronald J. Doll

Schering-Plough

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Kamil Paruch

Masaryk University

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Brian Mckittrick

Schering-Plough

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Carmen Alvarez

Schering-Plough

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Duane A. Burnett

Merck

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