Chan-Hum Park

Usefulness of Ultrasonography in the Treatment of Nasal Bone Fractures

BACKGROUND Ultrasonography has recently been used in assessment and diagnosis of maxillofacial trauma because it is easy and quick to perform, inexpensive, portable, and noninvasive. The aim of this study was to estimate ultrasonography as an intraoperative repositioning control of nasal bone fractures. METHODS We studied 32 patients with suspected nasal bone fracture. We performed preoperative computed tomography (CT) for evaluation of the type and extent of nasal bone fractures. We also took external photographs for evaluation of external deviation of the nose and nasal deformity. During surgery, we performed real-time ultrasonography-guided closed reduction using a 10 MHz linear transducer. After 1 year, we performed postoperative evaluation with CT and external photography. We classified patients into three groups according to their CT score. RESULTS Patients were 23 males and 9 females aged 8-39 years. Clinical symptoms were pain, nasal swelling, nasal bleeding, and localized depression at the trauma site. In almost all patients, postoperative external photographs showed a symmetrical nasal dorsum without external deformity, and postoperative CT showed stabilization of bony fragments and good alignment of the nasal bone. Postoperatively, the CT score was 3 (excellent) in 25 patients, 2 (good) in 5 patients, and 1 (fair) in 2 patients. CONCLUSION We suggest that ultrasonography is very useful for evaluating intraoperative repositioning of nasal bone fractures.

R028: Histologic Change of Implanted Gore-Tex® in Rabbit

(HNSCC) are infiltrated with cells from the mononuclear phagocyte system (MNP), which have the ability to bind and, if activated, kill tumor cells. IL-6 and MCP-1 are cytokines that play a role in the development and metastasis of cancer. METHODS: An organ culture method was used by which small parts of tissues, either from HNSCC or benign mucosa, could be maintained viable in vitro as Fragment (F)-spheroids. F-spheroids stimulate autologous monocytes to secrete interleukin (IL)-6 and monocyte chemotactic protein (MCP)-1 in vitro. The team analysed the IL-6 and MCP-1 production from monocytes in coculture with autologous F-spheroids in a cohort of patients from 1998 to 2005, all treated for HNSCC. RESULTS: The team found increased production of IL-6 by autologous monocytes, in coculture with F-spheroids, correlating with more recurrence (p 0,05) and to some extent impaired general survival. CONCLUSION: Monocytes in coculture with autologous Fspheroids produce IL-6 and MCP-1. The IL-6 production is shown to be a prognostic factor in vitro in HNSCC. SIGNIFICANCE: Knowledge of the interactions between the MNP and cancer cells may eventually lead to an (immuno) therapy which might give a better survival rate for patients with HNSCC. SUPPORT: The work was supported by the Norwegian Cancer Society and the University in Bergen.