Chan-yong Jun
Gachon University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Chan-yong Jun.
Mediators of Inflammation | 2014
Youn Kyung Choi; Ki Yong Jung; Sang-Mi Woo; Yee Jin Yun; Chan-yong Jun; Jong Hyeong Park; Yong Cheol Shin; Sung-Gook Cho; Seong-Gyu Ko
Cancer-associated anorexia and cachexia are a multifactorial condition described by a loss of body weight and muscle with anorexia, asthenia, and anemia. Moreover, they correlate with a high mortality rate, poor response to chemotherapy, poor performance status, and poor quality of life. Cancer cachexia is regulated by proinflammatory cytokines such as interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor-α (TNF-α). In addition, glucagon like peptide-1 (GIP-1), peptide YY (PYY), ghrelin, and leptin plays a crucial role in food intake. In this study, we investigated the therapeutic effects of one of the traditional herbal medicines, Sipjeondaebo-tang (Juzen-taiho-to in Japanese; SJDBT), on cancer anorexia and cachexia in a fundamental mouse cancer anorexia/cachexia model, CT-26 tumor-bearing mice. SJDBT was more significantly effective in a treatment model where it was treated after anorexia and cachexia than in a prevention model where it was treated before anorexia and cachexia on the basis of parameters such as weights of muscles and whole body and food intakes. Moreover, SJDBT inhibited a production of IL-6, MCP-1, PYY, and GLP-1 and ameliorated cancer-induced anemia. Therefore, our in vivo studies provide evidence on the role of SJDBT in cancer-associated anorexia and cachexia, thereby suggesting that SJDBT may be useful for treating cancer-associated anorexia and cachexia.
Evidence-based Complementary and Alternative Medicine | 2014
Sung-Gook Cho; Ho-Yeon Go; Jeong-Su Park; Ki-yong Jung; Seung-Ho Sun; You-kyung Choi; Yun-Kyung Song; Jong-Hyeong Park; Chan-yong Jun; Seong-Gyu Ko
Herbal prescription, Danggui-Sayuk-Ga-Osuyu-Saenggang-tang (DSGOST), has long been used to treat Raynauds phenomenon (RP) in traditional Chinese medicine (TCM). However, a biological mechanism by which DSGOST ameliorates RP is yet deciphered. In this study, we demonstrate that DSGOST inhibits cold-induced activation of RhoA, in both vascular smooth muscle cells (VSMC) and endothelial cells (EC), and blocks endothelin-1-mediated paracrine path for cold response on vessels. While cold induced RhoA activity in both cell types, DSGOST pretreatment prevented cold-induced RhoA activation. DSGOST inhibition of cold-induced RhoA activation further blocked α2c-adrenoreceptor translocation to the plasma membrane in VSMC. In addition, DSGOST inhibited endothelin-1-mediated RhoA activation and α2c-adrenoreceptor translocation in VSMC. Meanwhile, DSGOST inhibited cold-induced or RhoA-dependent phosphorylation of FAK, SRC, and ERK. Consistently, DSGOST inhibited cold-induced endothelin-1 expression in EC. Therefore, DSGOST prevents cold-induced RhoA in EC and blocks endothelin-1-mediated paracrine path between EC and VSMC. In conclusion, our data suggest that DSGOST is beneficial for treating RP-like syndrome.
Oriental Pharmacy and Experimental Medicine | 2005
Ho-Yeon Ko; Chan-yong Jun; Jong-Hyeong Park; Yoo-Sik Yoon; Sun-Dong Lee; Chang-Ho Han; Woo-Sang Jung; Sang-Kwan Moon; Ki-Ho Cho; Seong-Gyu Ko
Experts of Sasang Constitution Medicine of Traditional Korean Medicine have classified stroke patients with four types of Sasang constitutions in their clinical practice and some types of Sasang constitutions have been regarded as risk factors of stroke, but this is uncertain because there were no evidences by large scale of prospective studies. The purpose of this was to study the association between strokes and Sasang constitutions. Case-control study has been conducted to the patients admitted to the research hospitals. The patients were confirmed stroke by brain MRI or CT scans and recruited from May 2003 to August 2005. The subjects who met the requirement of inclusion and exclusion criteria were 108 patients as the cases and 107 as healthy controls. Data collection has been performed by the trained specialists majoring neurologists through interviews, physical examinations, and laboratory testes. No statistical significance was obtained between the strokes and Sasang constitutions, yet Taeumin, and Soyangin types showed a trend of increase in the incidence of strokes as compared with Soeumin. To acquire more concrete data on this theme, we need further and large scale of prospective researches.
Journal of Ethnopharmacology | 2007
Chang Hwa Jung; Hee Jung; Yong Cheol Shin; Jong-Hyeong Park; Chan-yong Jun; Hyung-Min Kim; Hee-Sun Yim; Min-Gyu Shin; Hyun-Soo Bae; Sung-Hoon Kim; Seong-Gyu Ko
Biological & Pharmaceutical Bulletin | 2006
Chang Hwa Jung; Chan-yong Jun; S.S. Lee; Chong-Hyeong Park; Ki-Ho Cho; Seong-Gyu Ko
Biological & Pharmaceutical Bulletin | 2004
Seonggyu Ko; Seung-Hee Koh; Chan-yong Jun; Chang-Gyu Nam; Hyunsu Bae; Minkyu Shin
International Immunopharmacology | 2005
Sangsoo Nam; Eunjung Ko; Seong-Kyu Park; Seong-Gyu Ko; Chan-yong Jun; Minkyu Shin; Moochang Hong; Hyunsu Bae
대한한의학회지 | 2004
Seung-Hee Koh; Seonggyu Ko; Chan-yong Jun; Chong-Hyeong Park
The Journal of Internal Korean Medicine | 2006
Jeong-woo Nam; See-Hyung Rhee; Mi-suk Kang; You-kyung Choi; Chan-yong Jun; Chong-Hyeong Park; Dong-woo Kim
Journal of Traditional Chinese Medicine | 2015
Ho-Yeon Go; Ju Ah Lee; Sunyoung Park; Sunju Park; Jeong-Su Park; Chunhoo Cheon; Seong-Gyu Ko; Kyung-hwan Kong; Chan-yong Jun; Jong-Hyeong Park; Mi-Ran Shin; Se-Hoon Lee