Chandrani Guin

One-pot synthesis of dihydropyrimidinones catalysed by lithium bromide: an improved procedure for the Biginelli reaction

LiBr catalyses efficiently the three component condensation reaction of an aldehyde, a β-ketoester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones in high yield.

An efficient chemo and regioselective oxidative nuclear bromination of activated aromatic compounds using lithium bromide and ceric ammonium nitrate

Abstract A mild, efficient and highly chemo- and regioselective method for the bromination of electron rich aromatic molecules has been developed by electrophilic substitution of Br + , which was generated in situ from LiBr using ceric ammonium nitrate as the oxidant. Free aromatic amines remained unaffected under the reaction conditions.

Stereoselective synthesis of trisubstituted tetrahydrofurans by radical cyclisation reaction using a hypophosphite salt. Application to the total synthesis of (±)-dihydrosesamin

The stereoselective synthesis of tetrahydrofurans has been achieved from bromoalkynes and bromoalkenes by intramolecular radical cyclisation using a hypophosphite salt. This radical cyclisation strategy has successfully been applied to the total synthesis of a naturally occurring bioactive furanolignan, dihydrosesamin.

A mild and efficient method for oxidative halodecarboxylation of α,β-unsaturated aromatic acids using lithium bromide/chloride and ceric ammonium nitrate

Abstract A mild and efficient ecofriendly method for the halodecarboxylation of α,β-unsaturated aromatic acids has been developed by using lithium bromide/chloride and ceric ammonium nitrate in acetonitrile–water at room temperature to afford the vinyl halides in moderate to good yields.

A short and stereoselective total synthesis of (±)-sesamin by radical cyclisation of an epoxide using a transition-metal radical source

Abstract A short, efficient and stereoselective synthesis of a furofuran lignan, (±)-sesamin, has been achieved in good overall yield through the radical cyclisation of an epoxide using a Ti(III) reagent as the radical initiator.