Chang-Duk Kim

Analysis of genes responding to ultraviolet B irradiation of HaCaT keratinocytes using a cDNA microarray.

Background  Ultraviolet (UV) B irradiation causes many important biological changes in skin, which lead to pathophysiological alterations of the homeostatic environment.

Hair greying is associated with active hair growth

Background  Hair greying is an obvious sign of ageing in humans. White (nonpigmented) hair is thicker than black (pigmented) hair. The growth rate of white hair is also significantly higher than that of black hair. However, the mechanism underlying this is largely unknown.

Expression profiling of radiation‐induced genes in radiodermatitis of hairless mice

Background  Radiation induces many cellular events leading to radiodermatitis.

Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study

Isotretinoin has been frequently used for acne therapy. However, it has limitation in acceptance because of its adverse effects. Although antihistamine recently revealed to decrease the lipogenesis, evidence is lacking regarding the clinical relevance of antihistamine in the treatment of acne.

Proton pump inhibitors as a possible cause of vitiligo: an in vivo and in vitro study.

Vitiligo is an acquired depigmentation disorder of melanocytes. Recently, some clinical reports have suggested that proton pump inhibitors (PPIs) may worsen vitiligo, but their effects on melanocytes have yet to be elucidated.

Use of whole-exome sequencing to determine the genetic basis of signs of skin youthfulness in Korean women.

course of the disorder or the effect of mid-strength topical steroid alone in the present case. Nevertheless, this is the first reported case of a recovery from severe alopecia areata during oral tacrolimus treatment, whether or not it is accompanied by a pre-existing autoimmune disease or a transplant as the primary target. There is no sufficient evidence of the efficacy of topical mild potent steroids, but very potent topical steroids only for mild cases. It should be noted that tacrolimus reduces the expression of NKG2D from human NK cells and inhibits the subsequent T-cell activation and production of several cytokines, including IFN-c, IL-2 and TNF-a. Therefore, it is reasonable to consider that tacrolimus was effective in our case. Oral tacrolimus may be more effective than topical tacrolimus for alopecia areata. Topical tacrolimus was effective in a mouse model of alopecia areata, but it is not very effective in humans, probably because the tissue distribution of percutaneous tacrolimus is much less effective than that in experimental animals. Our case suggests the potentially therapeutic benefit of oral tacrolimus in alopecia areata. Well-controlled studies will clarify the efficacy and safety of this therapy.