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Publication
Featured researches published by Chang-Ho Park.
Journal of Life Science | 2009
Yong-Pil Cheon; Mohammad Lalmoddin Mollah; Chang-Ho Park; Joo-Heon Hong; Gee-Dong Lee; Jae-Chan Song; Kil-Soo Kim
Bulnesia sarmienti (BS), a traditional South American herbal medicine native to Gran Chaco, has been used to treat various human ailments. We investigated the cytotoxic activities and the inhibitory effects of BS bark extract(0, 50, 100 and ) on the production of nitric oxide (NO), prostaglandin (), cyclooxygenase (COX) and proinflammatory cytokines (, IL-6 and ) in the lipopolysaccharide (LPS) (100 ng/ml)-stimulated murine macrophage cell line RAW264.7. The levels of NO, COX, PGE2 production and proinflammatory cytokines (, IL-6 and ) were measured by ELISA kit. Cell viability, as measured by the MTT assay, showed that BS extract had no significant cytotoxicity in RAW264.7 cells. BS extract significantly inhibited the LPS-induced NO, and COX production accompanied by an attenuation of , IL-6 and formation in macrophages. These results suggest that BS extract has potential as an herbal medicine for the treatment of inflammatory diseases.
Oncology Research | 2009
Mohammad Lalmoddin Mollah; Jae-Chan Song; Chang-Ho Park; Gee-Dong Lee; Joo-Heon Hong; Zae Young Ryoo; Sanggyu Lee; Kyu-Tae Chang; Kil-Soo Kim
Bulnesia sarmienti (BS), a traditional South American herbal medicine native to Gran Chaco, has been used to treat various human ailments. The effects of BS aqueous extract (100, 200, and 400 microg/ml) on H460 cell lines were investigated. High-performance liquid chromatography (HPLC) confirmed that BS contains catechins as major compound. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, cell cycle analysis, DNA fragmentation, apoptosis, and immunoblot analysis on cells were carried out. BS has strong cytotoxic activity on the H460 cell lines (IC50; less than 100 microg/ml) in MTT assay. Flow cytometry indicated that BS arrested the cell cycle in the sub-G1 phase. When BS was treated on H460 cells, DNA fragmentation was increased, and early apoptotic cells were shown to be positive by annexin V staining. Also, the expressions of the p53 and Bax were increased and Bcl-2 protein was downregulated with BS treatment. These results indicated that the BS has anticancer activity on H460 cells and BS may be useful in future therapeutic applications for developing anticancer agents.
Immunopharmacology and Immunotoxicology | 2009
Mohammad Lalmoddin Mollah; Jung-Ok Kim; Gee-Dong Lee; Chang-Ho Park; Joo-Heon Hong; Hak-Yoon Kim; Kil-Soo Kim
The effects of Bulnesia sarmienti (BS) aqueous extract on the cell growth of A549 cell lines were investigated. BS has strong cytotoxic activity on the A549 cell lines (IC50; less than 100 μ g/mL) in MTT assay. HPLC confirmed that BS contains catechins as major compound. Cell cycle analysis by flow cytometry indicated that BS arrested the cell cycle in the sub-G1 phase. BS induced DNA fragmentation, and increased the expression of the p53 protein in immunoblot analysis. These results indicated that the anticancer effect of BS was mediated via the process of apoptosis and growth-inhibition.
Journal of Life Science | 2008
Chang-Ho Park; Jung-Ok Kim; Gee-Dong Lee; Kil-Soo Kim; Joo-Heon Hong
The effects of Bulnesia sarmienti water extract on lipid metabolism were investigated in type-1 diabetes rats. The rats were fed a basal diet and B. sarmienti water extract for 8 weeks. The rats were randomly assigned to each treatment group: normal, control, three kinds of treatment group (BWO: 0.45 mg/ml, BW1: 0.9 mg/ml, BW2: 1.8 mg/ml). After 8 weeks of experimental diets consumption, the body weights and food efficiency ratio of B. sarmienti water extract fed groups were not change with those in the control group. The concentration in plasma total-cholesterol, LDL-cholesterol, triglyceride were significantly decrease in the B. sarmienti water extract groups compared with those in the control group. Although it was not possible to observe blood glucose control effects of eight weeks of B. sarmienti water extract feeds in type-1 diabetes model, it was discovered that the feeds are highly effective in lowering the levels of blood lipid substances triglycerides, total-cholesterol, and LDL-cholesterol.
Journal of Life Science | 2008
Chang-Ho Park; Gee-Dong Lee; Jung-Ok Kim; Kil-Soo Kim; Won-Young Lee; Joo-Heon Hong
The effects of Bulnesia sarmienti water extract on lipid metabolism were investigated in type-2 diabetes rats. The rats were fed a basal diet and B. sarmienti water extract for 8 weeks. The rats were randomly assigned to each treatment group : normal, control, two kinds of treatment group (BW1: 0.9 mg/ml, BW2: 1.8 mg/ml). After 8 weeks of experimental diets consumption, the body weights and food efficiency ratio of B. sarmienti water extract fed groups were not different from those in the control group. The concentrations of total-cholesterol, LDL-cholesterol, and triglyceride in blood plasma were significantly decreased in the B. sarmienti water extract groups comparison to the control group. Although blood glucose control effects were not observed, the B. sarmienti water extract feeds were highly effective in lowering the levels of blood lipid substances such as triglycerides, total-cholesterol, and LDL-cholesterol.
Applied Biological Chemistry | 2011
Hee Kyung Jung; Yoo Seok Jeong; Chi-Duck Park; Chang-Ho Park; Joo-Heon Hong
Korean Journal of Food Preservation | 2011
Chang-Ho Park; Hee-Kyoung Jung; Yoo-Seok Jeong; Joo-Heon Hong; Gee-Dong Lee; Chi-Deok Park
Korean Journal of Food Science and Technology | 2008
Chang-Ho Park; Dae-Ik Kim; Eun-Ji Shin; Gee-Dong Lee; Jung-Ok Kim; Kil-Soo Kim; Joo-Heon Hong
Laboratory Animal Research | 2008
Chang-Ho Park; Joo-Heon Hong; Jung-Ok Kim; Kil-Soo Kim; Gee-Dong Lee
한국실험동물학회 학술발표대회 논문집 | 2008
Mohammad Lalmoddin Mollah; Gee-Dong Lee; Jung-Ok Kim; Chang-Ho Park; Hak-Yoon Kim; Kil-Soo Kim