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Featured researches published by Chang Min Kim.


Annals of Surgical Oncology | 2012

Integrated Analysis of Prognostic Gene Expression Profiles from Hepatitis B Virus-Positive Hepatocellular Carcinoma and Adjacent Liver Tissue

Bu Yeo Kim; Kyung-Suk Suh; Je Geun Lee; Seon Rang Woo; In Chul Park; Sun Hoo Park; Chul Han; Sang Bum Kim; Sook Hyang Jeong; Young Il Yeom; Suk Jin Yang; Chang Min Kim; Su Jin Cho; Young Do Yoo; Myung Haing Cho; Ja June Jang; Dong Wook Choi; Kee Ho Lee

BackgroundThe tissue environment in the region of hepatocellular carcinoma (HCC) influences both vascular invasion and recurrence. Thus, HCC patient prognosis depends on the characteristics not only of the tumor but also those of adjacent surrounding liver tissue.Materials and MethodsExpression profiles of both tumor and adjacent liver tissue following curative resection were measured to discriminate 56 hepatitis B virus-positive HCC patients into subgroups based on survival risk. This approach was further tested in 40 patients.ResultsExpression profiles of both tumor and adjacent liver tissue successfully discriminated 56 training samples into 2 subgroups, those at low- or high-risk for survival and recurrence. However, the prognostic gene set selected for tumor tissue was quite different from that for adjacent tissues. This variation in prognostic genes resulted in a change in allocation of patients within each low- or high-risk group. Combination of survival subgroups from tumor and adjacent liver tissue significantly improved the prediction of prognostic outcome. This integrative approach was confirmed to be effective in a further 40 test patients. A clinicopathological study showed that survival subgroups divided by tumor and adjacent liver tissue gene expression were also statistically associated with UICC stage and extent of cell differentiation, respectively.ConclusionsVariation in gene expression during the nontumor stage as well as the tumor stage may affect the prognosis of HCC patients, and integration of the gene expression profiles of HCC and adjacent liver tissue increases discriminatory effectiveness between patient groups, predicting clinical outcomes with enhanced statistical reliability.


Journal of Korean Medical Science | 1992

Modification of adriamycin-induced cytotoxicity by recombinant human interferon-gamma and/or verapamil in human stomach cancer cells.

Weon Seon Hong; Chang Min Kim; Choon Taek Lee; Jhin Oh Lee; Tae Woong Kang

Recombinant human-interferon-gamma (rH-IFN-gamma) and verapamil (VRP), either alone or in combination, were evaluated in MTT assay for their modification effects on adriamycin-induced cytotoxicity against MKN-45, human stomach adenocarcinoma cells. VRP as a single agent did not inhibit the survival of MKN-45 at doses of up to 5.0 micrograms/ml. The survival of MKN-45 was inhibited by rH-IFN-gamma dose-dependently and further inhibited by the addition of VRP. However, the maximum growth inhibition of MKN-45 in any combination treatment with rH-IFN-gamma and VRP was less than 50% except in the highest concentration combinations (% survival: 47.9% at 10(4) U/ml of rH-IFN-gamma and 3.0 micrograms/ml of VRP). Adriamycin caused a concentration-dependent cytotoxicity and its cytotoxicity was significantly enhanced by the addition of rH-IFN-gamma and further enhanced by the combined use of rH-IFN-gamma and VRP. The modification effects of rH-IFN-gamma and VRP on adriamycin-induced cytotoxicity were evaluated in terms of modification index (MI), demonstrating that rH-IFN-gamma significantly increased in adriamycin-induced cytotoxicity and that the combined use of rH-IFN-gamma and VRP enhanced the adriamycin-induced cytotoxicity to a greater extent than did rH-IFN-gamma alone: MI values at 10(2) U/ml and 10(3) U/ml of rH-IFN-gamma were 1.7 and 3.1, respectively; those at 1.5 micrograms/ml and 3.0 micrograms/ml of VRP in the presence of 10(3) U/ml of rH-IFN-gamma were 4.4 and 6.0, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)


The Korean Journal of Hepatology | 2004

[The clinical report of 1,078 cases of hepatocellular carcinomas: National Cancer Center experience].

Jae Hee Cheon; Joong Won Park; Kyung Woo Park; Yoon-Goo Kim; Seong-Hoon Kim; Woo Jung Lee; Park Hs; Semi Park; Hong Ek; Chang Min Kim


Journal of Korean Medical Science | 1993

Loss of retinoblastoma gene and amplification of N-myc gene in retinoblastoma.

Sang Wook Choi; Tai Won Lee; Sung Wook Yang; Weon Seon Hong; Chang Min Kim; Jhin Oh Lee


The Korean Journal of Hepatology | 2006

[Diagnostic accuracy of 18F-FDG positron emission tomography for evaluation of hepatocellular carcinoma].

Shin Ja; Joong Won Park; An M; Choi Ji; Sung Hoon Kim; Sung Kook Kim; Woo Jung Lee; Semi Park; Hong Ek; Chang Min Kim


The Korean Journal of Hepatology | 2006

The adverse effect of indirectly diagnosed portal hypertension on the complications and prognosis after hepatic resection of hepatocellular carcinoma

An M; Joong Won Park; Shin Ja; Choi Ji; Tae Hyo Kim; Sung Hoon Kim; Woo Jung Lee; Semi Park; Hong Ek; Chang Min Kim


The Korean Journal of Hepatology | 2006

[Survival analysis for patients with hepatocellular carcinoma according to stage, liver function and treatment modalities].

Kyung Woo Park; Joong Won Park; Se Hyun Cho; Yoon-Goo Kim; Sung Hoon Kim; Park Hs; Woo Jung Lee; Sung Jae Park; Doyoung Kim; Hong Ek; Chang Min Kim


Journal of Korean Medical Science | 1993

Chemosensitization to adriamycin by cyclosporin A and verapamil in human retinoblastoma cell lines.

Tai Won Lee; Sung Wook Yang; Chang Min Kim; Weon Seon Hong; Dong Ho Youn


The Korean Journal of Hepatology | 2001

Clinical Characteristics of Non-B, Non-C Hepatocellular Carcinoma and Detection of HBV, HCV and TTV Viremia

Cho Hh; Kim Yh; Jung Jm; Cho Kh; Se Hyun Cho; Choi Dh; Sook Hyang Jeong; J. Lee; Han Cj; You Cheoul Kim; Jhin Oh Lee; Chang Min Kim


The Korean Journal of Hepatology | 2006

[Liver metastasis of colon cancer with a high serum alpha-fetoprotein level: report of a case].

An M; Shin Ja; Lee Sm; Yoon T; Park Ws; Choi Ji; Chang Min Kim

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Se Hyun Cho

Catholic University of Korea

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Sook Hyang Jeong

Seoul National University Bundang Hospital

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Byung Hee Lee

Pusan National University

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Choon Taek Lee

Seoul National University

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Chul Ju Han

Seoul National University

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