Chang Woon Choi
Seoul National University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Chang Woon Choi.
Clinical Nuclear Medicine | 1995
Chang Woon Choi; Dong Soo Lee; June-Key Chung; Myung Chul Lee; Noe Kyeong Kim; Kyoo Wan Choi; Chang-Soon Koh
The authors conducted a retrospective review of 234 bone scans of stomach cancer patients who had been diagnosed at the Seoul National University Hospital. In 106 of the 234 cases (45.3%), there were abnormal bone scan results, suggestive of bone metastases. The most common site of bone metastases was the spine, followed by the ribs, pelvis, femur, and skull. These sites were similar to those known for other malignant diseases. The incidence of bone metastases increased according to the duration of disease, especially within 12 months after diagnosis in patients with stage III gastric cancer. The incidence of bone metastases increased as the clinical stage increased. However, the incidence of metastases did not relate to gastric cancer pathologic type. The authors found 6 cases of “superscan” In the 234 bone scans (2.6%). The bone scan findings correlated positively with the level of serum alkaline phosphatase.
Nuclear Medicine and Biology | 1995
Chang Woon Choi; June-Key Chung; Dong Soo Lee; Myung Chul Lee; Hong-Keun Chung; Byoung Kook Kim; Chang-Soon Koh
We evaluated the monoclonal antibody CEA-79.4 against carcinoembryonic antigen as an immunoscintigraphic agent for assessing the state of the bone marrow. Western blotting of human granulocyte extracts with the antibody could confirm that the binding was with the epitope of NCA-95. Immunocytochemical staining of bone marrow aspirates revealed specific uptake of this antibody by granulopoietic cells. The affinity constant was 2-9 x 10(9) L/mol. Immunoscintigraphy using 99mTc-labeled CEA-79.4 in a normal volunteer revealed high uptake in the bone marrow as compared to other organs.
Annals of Nuclear Medicine | 1993
June-Key Chung; Chang Woon Choi; Myung Chul Lee; Hong-Keun Chung; Neo Kyeong Kim; Kyoo Wan Choi; Chang-Soon Koh
CEA-79 is a murine IgG2a type monoclonal antibody (MoAb) generated using purified CEA from culture supernatants of a human colon cancer cell line, LS174T. The association constant and immunoreactivity of the I-131 labeled CEA-79 ranged from 2.0 to 3.2 ×109 l/mole, and from 54 to 74 %, respectively. The purpose of this study was to evaluate the feasibility of radioimmunoscintigraphy employing MoAb CEA-79 in patients with advanced gastrointestinal carcinomas. Two mgs of MoAb CEA-79 was labeled with 111 MBq (3 mCi) of I-131, and infused intravenously in 6 stomach cancer and 16 colon cancer patients. Out of 6 patients with stomach cancer, immunoscintigraphy was able to detect the tumors in 4 cases. However, immunoscintigraphy found out tumors in all patients with colon cancer. Moreover, 1 patient with stomach cancer and 2 patients with colon cancer showed increased uptake of MoAb in the tumor lesions despite normal serum levels of CEA. We could conclude that this antibody has a potential as a new imaging agent for the diagnosis of gastrointestinal carcinoma.
The Journal of Nuclear Medicine | 1999
June-Key Chung; Young Ho So; Jae Sung Lee; Chang Woon Choi; Sang Moo Lim; Dong Soo Lee; Sung Woon Hong; Yeo Kyu Youn; Myung Chul Lee; Bo Youn Cho
The Journal of Nuclear Medicine | 1997
Sang Eun Kim; Chang Woon Choi; Byung-Woo Yoon; June-Key Chung; Jae Kyu Roh; Myung Chul Lee; Chang-Soon Koh
The Journal of Nuclear Medicine | 1995
Kyung Han Lee; June-Key Chung; Chang Woon Choi; Jae Min Jeong; Dong Soo Lee; Yung Jue Bang; Myung Chul Lee; Noe Kyung Kim; Chang-Soon Koh
Society of Nuclear Medicine Annual Meeting Abstracts | 2014
Byung Hyun Byun; Chang-Bae Kong; Ilhan Lim; Byung Il Kim; Chang Woon Choi; Sang Moo Lim
Society of Nuclear Medicine Annual Meeting Abstracts | 2013
Ji-Hyun Park; Ilhan Lim; Eung-Ho Cho; Sang Bum Kim; Young Han Kim; Kyeong Min Kim; Byung Hyun Byun; Byung Il Kim; Chang Woon Choi; Sang Moo Lim
Society of Nuclear Medicine Annual Meeting Abstracts | 2014
Kyoung Jin Chang; Ilhan Lim; Han Sol Moon; Ji Hyun Park; Byung Hyun Byun; Jae Soo Ko; Byung Il Kim; Chang Woon Choi; Sang Moo Lim
Society of Nuclear Medicine Annual Meeting Abstracts | 2014
Byung Hyun Byun; Chang-Bae Kong; Ilhan Lim; Byung Il Kim; Chang Woon Choi; Sang Moo Lim