Chang Young Jung

Synthesis and photophysical properties of silicon(IV) tetrapyrazinoporphyrazines axially substituted with ethylene glycol chains as potential photosensitizer

Photodynamic therapy involves administration of a tumor-localizing photosensitizer, which may require metabolic conversion, followed by activation of the photosensitizer with light of a specific wavelength. In this paper, we report the design and synthesis of silicon(IV) tetrapyrazinoporphyrazines derived from 5,9,9-trimethyl-5,6,7,8-tetrahydro-5,8-methanoquinoxaline-2,3-dicarbonitrile. The HO–(CH2CH2O)n–CH3 groups were introduced at axial positions to give a specific functionality. In particular, poly(ethylene glycol) groups were expected to increase water solubility without changing the λmax.

Synthesis and spectral properties of tetraquinoxalino-porphyrazines containing benzocrown-ether group

The synthesis and spectral properties of the metal-free and the Mg complex derivatives of crown-substituted tetraquinoxalinoporphyrazine are described. Porphyrazine 4 and 5 have satisfactory solubility in chlorinated hydrocarbons, THF and toluene, but are practically insoluble in alcohols. Porphyrazine 5 generally did not show aggregation in CHCl3 but aggregate in DMF.