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Dive into the research topics where Changsheng Zhao is active.

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Featured researches published by Changsheng Zhao.


Polymer Chemistry | 2010

Oxidant-induced dopamine polymerization for multifunctional coatings

Qiang Wei; Fulong Zhang; Jie Li; Beijia Li; Changsheng Zhao

Polydopamine-coatings can be prepared in acidic, neutral and alkaline aqueous media by oxidant-induced polymerization, which is material-independent and multifunctional for surface modification.


Journal of Materials Chemistry B | 2013

Biopolymer functionalized reduced graphene oxide with enhanced biocompatibility via mussel inspired coatings/anchors

Chong Cheng; Shengqiang Nie; Shuang Li; Hong Peng; Hang Yang; Lang Ma; Shudong Sun; Changsheng Zhao

A green and facile method for preparing biopolymer functionalized reduced graphene oxide (RGO) by using mussel inspired dopamine (DA) as the reducing reagent and the functionalized molecule is proposed. In the study, GO is reduced by DA and DA is adhered to RGO by one-step pH-induced polymerization of DA (polydopamine, PDA), and then heparin or protein is grafted onto the PDA adhered RGO (pRGO) through catechol chemistry. The obtained pRGO, heparin grafted pRGO (Hep-g-pRGO), and BSA grafted pRGO (BSA-g-pRGO) exhibit fine 2D morphology and excellent stability in water and PBS solution. Furthermore, the biocompatibility of the biopolymer functionalized RGO are investigated using human blood cells and human umbilical vein endothelial cells (HUVECs). The biopolymer functionalized RGO exhibits an ultralow hemolysis ratio (lower than 1.8%), and the cellular toxicity assay suggests that the biopolymer functionalized RGO has good cytocompatibility for HUVEC cells, even at a high concentration of 100 μg mL-1. Moreover, the high anticoagulant ability of Hep-g-pRGO indicates that the grafted biopolymer could maintain its biological activity after immobilization onto the surface of pRGO. Therefore, the proposed safe and green biomimetic method confers the biopolymer functionalized RGO with great potential for various biological and biomedical applications.


Acta Biomaterialia | 2011

Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone).

Fen Ran; Shengqiang Nie; Weifeng Zhao; Jie Li; Baihai Su; Shudong Sun; Changsheng Zhao

An amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone) (PVP-b-PMMA-b-PVP) was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The block co-polymer can be directly blended with polyethersulfone (PES) using dimethylacetamide (DMAC) as the solvent to prepare flat sheet and hollow fiber membranes using a liquid-liquid phase separation technique. The PVP block formed a brush on the surface of the blended membrane, while the PMMA block mingled with the PES macromolecules, which endowed the membrane with permanent hydrophilicity. After adding the as-prepared block co-polymer the modified membranes showed lower protein (bovine serum albumin) adsorption, suppressed platelet adhesion, and a prolonged blood coagulation time, and thereby the blood compatibility was improved. Furthermore, the modified PES membranes showed good cytocompatibility, ultrafiltration and protein anti-fouling properties. These results suggest that surface modification of PES membranes by blending with the amphiphilic triblock co-polymer PVP-b-PMMA-b-PVP allows practical application of these membranes with good biocompatibility in the field of blood purification, such as hemodialysis and bioartificial liver support.


Journal of Materials Science: Materials in Medicine | 2010

Preparation of silver nanoparticles with antimicrobial activities and the researches of their biocompatibilities.

X. L. Cao; Chong Cheng; Y. L. Ma; Changsheng Zhao

Silver nanoparticles were prepared by chemical reduction method using chitosan as stabilizer and ascorbic acid as reducing agent in this work. The silver/chitosan nanocomposites were characterized in terms of their particle sizes and morphology by using UV spectrophotometer, nano-grainsize analyzer, and transmission electron microscopy. Antibacterial activities of these nanocomposites were carried out for Staphylococcus aureus and Escherichia coli. The silver nanoparticles exhibited significantly inhibition capacity towards these bacteria. Detailed studies on the biocompatibility of the silver/chitosan nanocomposites were investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and cell adhesion test. The results indicated that these silver/chitosan nanocomposites were benefit for the proliferation and adhesion of L-929 cells, and the biocompatibilities between the nanocomposites and the cells would become better with the culturing days. We anticipated that these silver/chitosan nanocomposites could be a promising candidate as coating material in biomedical engineering and food packing fields wherein antibacterial properties and biocompatibilities are crucial.


Journal of Materials Chemistry B | 2014

Mussel-inspired self-coating at macro-interface with improved biocompatibility and bioactivity via dopamine grafted heparin-like polymers and heparin

Lang Ma; Hui Qin; Chong Cheng; Yi Xia; Chao He; Chuanxiong Nie; L. Wang; Changsheng Zhao

In this study, multifunctional mussel-inspired self-coated membranes with remarkable blood and cell compatibilities are prepared by a facile and green approach. A highly sulfonated linear heparin-like polymer (HepLP, poly(sodium 4-vinylbenzenesulfonate)-co-poly(sodium methacrylate)) and heparin are chosen for the mussel-inspired heparin-mimicking coating, respectively. Firstly, DA is grafted onto the backbone of HepLP or heparin to obtain DA grafted HepLP (DA-g-HepLP) or DA grafted heparin (DA-g-Hep) by means of the carbodiimide chemistry method. Then, the DA-g-HepLP and DA-g-Hep are used to prepare surface coated heparin-mimicking substrates; the polyethersulfone (PES) dialysis membrane is chosen as the model substrate. The coated surface composition, surface morphology, water contact angle, surface zeta-potential, blood compatibility and cell compatibility are systematically investigated. The results of surface spectra, scanning electron microscopy (SEM) and atomic force microscopy (AFM) indicated that the DA-g-HepLP and DA-g-Hep were successfully coated onto the membranes. The coated membranes showed increased hydrophilicity and electronegativity, decreased plasma protein adsorption, and suppressed platelet adhesion compared to the pristine membrane. The cell morphology observation and cytotoxicity assays demonstrated that the surface coated heparin-mimicking membranes showed superior performance in endothelial cell proliferation and morphology differentiation. In addition, the excellent anticoagulant bioactivities indicated that the adhered DA-g-HepLP (or DA-g-Hep) could function or maintain its biological activity after the immobilization. In general, the mussel-inspired protocol of surface self-coating conferred the modified membranes with integrated blood compatibility, cell proliferation and biological activity for multi-biomedical applications, like hemodialysis, blood purification, organ implantation, and cell and tissue cultures.


Colloids and Surfaces B: Biointerfaces | 2010

Immobilization of silver nanoparticles onto sulfonated polyethersulfone membranes as antibacterial materials

Xuelian Cao; Ming Tang; Fei Liu; Yuanyang Nie; Changsheng Zhao

By using the interaction between the sulfonated groups and silver ions, silver nanoparticles were successfully introduced onto the surface of sulfonated polyethersulfone (SPES) membranes by using vitamin C as reducing agent. The presence of silver nanoparticles on the surface of the PES/SPES hybrid membranes was characterized by UV spectrophotometer, scanning electron microscopy and transmission electron microscopy. Detailed studies on the antibacterial activity of the (PES/SPES)-Ag composites were carried out for Staphylococcus aureus, Staphylococcus albus, and Escherichia coli, for which, the composites exhibited significantly inhibition capacity. Cytocompatibility of the (PES/SPES)-Ag composites were also investigated by cell cytotoxicity and cell adhesion tests. The results indicated that after immobilizing with silver nanoparticles, the (PES/SPES)-Ag was still within the safe use range. To our knowledge, this is the first time that PES membranes have been prepared with antibacterial capacity. We anticipate that this novel and green method might lead to an expanded usage of PES with antibacterial properties in medical instruments and food processing industries in the future, and might also make a potential contribution to the fields of antibacterial chemistry.


Desalination | 2000

Determination of pore size and pore size distribution on the surface of hollow-fiber filtration membranes : a review of methods

Changsheng Zhao; Xuesong Zhou; Yilun Yue

Various methods to characterize the pore size and pore size distribution of hollow-fiber porous filtration membranes were reviewed. First, the microscopy observation method, which was the most direct method to characterize the membrane pore structure, was reviewed. Second, the thermoporometry method and a method based on water permeability were reviewed. The last method, which relates to solute or particle permeation performance, was reviewed in depth. Various transport models had been developed which could be used for the characterization, and the models and structure analysis by using the models were explained.


Biomacromolecules | 2012

General and Biomimetic Approach to Biopolymer-Functionalized Graphene Oxide Nanosheet through Adhesive Dopamine

Chong Cheng; Shuang Li; Shengqiang Nie; Weifeng Zhao; Hang Yang; Shudong Sun; Changsheng Zhao

Graphene oxide (GO), reduced graphene oxide (rGO), and their derivatives are investigated for various biomedical applications explosively. However, the defective biocompatibility was also recognized, which restricted their potential applications as biomaterials. In this study, a facile biomimetic approach for preparation of biopolymer adhered GO (rGO) with controllable 2D morphology and excellent biocompatibility was proposed. Mussel-inspired adhesive molecule dopamine (DA) was grafted onto heparin backbone to obtain DA grafted heparin (DA-g-Hep) by carbodiimide chemistry method; then, DA-g-Hep was used to prepare heparin-adhered GO (Hep-a-GO) and heparin-adhered rGO (Hep-a-rGO). The obtained heparin-adhered GO (rGO) showed controllable 2D morphology, ultrastable property in aqueous solution, and high drug and dye loading capacity. Furthermore, the biocompatibility of the heparin-adhered GO (rGO) was investigated using human blood cells and human umbilical vein endothelial cells, which indicated that the as-prepared heparin-adhered GO (rGO) exhibited ultralow hemolysis ratio (lower than 1.2%) and high cell viability. Moreover, the highly anticoagulant bioactivity indicated that the adhered heparin could maintain its biological activity after immobilization onto the surface of GO (rGO). The excellent biocompatibility and high bioactivity of the heparin-adhered GO (rGO) might confer its great potentials for various biomedical applications.


Journal of Hazardous Materials | 2013

Toward 3D graphene oxide gels based adsorbents for high-efficient water treatment via the promotion of biopolymers.

Chong Cheng; Jie Deng; Bei Lei; Ai He; Xiang Zhang; Lang Ma; Shuang Li; Changsheng Zhao

Recent studies showed that graphene oxide (GO) presented high adsorption capacities to various water contaminants. However, the needed centrifugation after adsorption and the potential biological toxicity of GO restricted its applications in wastewater treatment. In this study, a facile method is provided by using biopolymers to mediate and synthesize 3D GO based gels. The obtained hybrid gels present well-defined and interconnected 3D porous network, which allows the adsorbate molecules to diffuse easily into the adsorbent. The adsorption experiments indicate that the obtained porous GO-biopolymer gels can efficiently remove cationic dyes and heavy metal ions from wastewater. Methylene blue (MB) and methyl violet (MV), two cationic dyes, are chosen as model adsorbates to investigate the adsorption capability and desorption ratio; meanwhile, the influence of contacting time, initial concentration, and pH value on the adsorption capacity of the prepared GO-biopolymer gels are also studied. The GO-biopolymer gels displayed an adsorption capacity as high as 1100 mg/g for MB dye and 1350 mg/g for MV dye, respectively. Furthermore, the adsorption kinetics and isotherms of the MB were studied in details. The experimental data of MB adsorption fitted well with the pseudo-second-order kinetic model and the Langmuir isotherm, and the results indicated that the adsorption process was controlled by the intraparticle diffusion. Moreover, the adsorption data revealed that the porous GO-biopolymer gels showed good selective adsorbability to cationic dyes and metal ions.


Biomaterials | 2003

Blood compatible aspects of DNA-modified polysulfone membrane—protein adsorption and platelet adhesion

Changsheng Zhao; Xiang Dong Liu; Motoyoshi Nomizu; Norio Nishi

DNA was used as a biomaterial to modify the polysulfone (PSf) membrane by blending it with PSf. The blood compatibility of the membranes was then investigated. The water contact angle decreased, and the hydrophilicity increased when a single strand DNA was blended with PSf. Because of the hydrophilic surface, the DNA-blended PSf membranes had a lower protein adsorption than the PSf membrane, but it was not significantly decreased due to the interaction between the DNA and proteins. Circular dichroism (CD) spectroscopy was used to examine the changes in the secondary structure of the proteins after adsorption onto the polymer surface and desorption from the polymer surface into the SDS solution. The conformation of the proteins adsorbed onto the PSf membrane and desorbed from the PSf membrane significantly changed, but that of the proteins for the DNA-blended PSf membranes differed only slightly from the native one. The number of platelets that adhered on the surface of the DNA-blended PSf membranes was reduced compared to that on the PSf membrane. This suggested that DNA can be regarded as a biopolymer to modify PSf, and contributes to the hydrophilic and hemocompatible wipers on the surface of the hydrophobic PSf membranes.

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Chong Cheng

Free University of Berlin

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