Chao Fu Wang

Anaplastic lymphoma kinase-positive large B-cell lymphoma: a potential diagnostic pitfall.

Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK + LBCL) is a rare variant of LBCL with an abnormal immunophenotype, which is easily misdiagnosed as carcinoma or plasma cell neoplasm. Here, we present two cases of ALK + LBCL in the lymph node; describe their clinical, pathological, and immunophenotype features; and compare them with those of the reported cases.

Primary plemorphic adenoma of bone: Report of a case and literature review

Plemorphic adenoma mainly occurs in the salivary glands. A similar tumor arising in the bone is extremely rare, and only three cases have been reported so far. Here, we present an additional case of primary plemorphic adenoma of bone; describe its clinical, pathological and radiological features; and compare them with those of the reported cases.

Myoid Harmatoma of the Breast: Clinicopathologic Analysis of a Rare Tumor Indicating Occasional Recurrence Potential

To the Editor: Myoid hamartoma (MH) is an extremely rare subtype of breast hamartoma characterized by the presence of myoid cell bundles in the stroma. Only approximately 30 cases have been reported to date. So its biological behavior, clinicopathologic features and histological origin are not well characterized. Moreover, its potential recurrence is usually overlooked. To the best of our knowledge, no case of MH with local recurrence has been reported previously. Herein, we described clinicopathologic features of five MHs, containing two recurrent lesions. Our aim is to elucidate pathologic features of MH, and to lay stress on its recurrence potential to evoke attentions of pathologists and surgeons. Five cases of MH were collected in the Department of Pathology, Shanghai Cancer Center, Fudan University, Shanghai. For each case, sections of 5 lm were cut from paraffin blocks for HE and immunohistochemistry using Envision method. The primary antibodies included vimentin, desmin, h-caldesmon, calponin, SMA, MSA. One case was studied ultrastructurally. The age of five patients ranged from 29 to 44 years (mean, 39 years). Physical examinations all revealed nontender, palpable lumps. The radiological information of two patients was available. On Mammography, two lesions appeared as ovoid to rounded, well circumscribed masses of mixed heterogenous density. A thin smooth capsule with peripheral radiolucent zone was seen in one lesion. In MRI, the lesion displayed an ovoid, well-defined mass with heterogenous enhancement, a focal dark thin rim. Internal fat intensity was demonstrated. All patients underwent lumpectomy. Three patients were well after the initial surgery. However, two cases developed local recurrence. One case relapsed 10 months following the initial surgery. Another recurred twice, with an interval of 36 and 41 months, respectively. Moreover, when recurred for the second time there were two separate