Chao-Hsien Hsieh

Different Brain Network Activations Induced by Modulation and Nonmodulation Laser Acupuncture

The aim of this study is to compare the distinct cerebral activation with continued wave (CW) and 10 Hz-modulated wave (MW) stimulation during low-level laser acupuncture. Functional magnetic resonance imaging (fMRI) studies were performed to investigate the possible mechanism during laser acupuncture stimulation at the left foots yongquan (K1) acupoint. There are 12 healthy right-handed volunteers for each type of laser stimulation (10-Hz-Modulated wave: 8 males and 4 females; continued wave: 9 males and 3 females). The analysis of multisubjects in this experiment was applied by random-effect (RFX) analysis. In CW groups, significant activations were found within the inferior parietal lobule, the primary somatosensory cortex, and the precuneus of left parietal lobe. Medial and superior frontal gyrus of left frontal lobe were also aroused. In MW groups, significant activations were found within the primary motor cortex and middle temporal gyrus of left hemisphere and bilateral cuneus. Placebo stimulation did not show any activation. Most activation areas were involved in the functions of memory, attention, and self-consciousness. The results showed the cerebral hemodynamic responses of two laser acupuncture stimulation modes and implied that its mechanism was not only based upon afferent sensory information processing, but that it also had the hemodynamic property altered during external stimulation.

Brain deactivation in the outperformance in bimodal tasks: an FMRI study.

While it is known that some individuals can effectively perform two tasks simultaneously, other individuals cannot. How the brain deals with performing simultaneous tasks remains unclear. In the present study, we aimed to assess which brain areas corresponded to various phenomena in task performance. Nineteen subjects were requested to sequentially perform three blocks of tasks, including two unimodal tasks and one bimodal task. The unimodal tasks measured either visual feature binding or auditory pitch comparison, while the bimodal task required performance of the two tasks simultaneously. The functional magnetic resonance imaging (fMRI) results are compatible with previous studies showing that distinct brain areas, such as the visual cortices, frontal eye field (FEF), lateral parietal lobe (BA7), and medial and inferior frontal lobe, are involved in processing of visual unimodal tasks. In addition, the temporal lobes and Brodmann area 43 (BA43) were involved in processing of auditory unimodal tasks. These results lend support to concepts of modality-specific attention. Compared to the unimodal tasks, bimodal tasks required activation of additional brain areas. Furthermore, while deactivated brain areas were related to good performance in the bimodal task, these areas were not deactivated where the subject performed well in only one of the two simultaneous tasks. These results indicate that efficient information processing does not require some brain areas to be overly active; rather, the specific brain areas need to be relatively deactivated to remain alert and perform well on two tasks simultaneously. Meanwhile, it can also offer a neural basis for biofeedback in training courses, such as courses in how to perform multiple tasks simultaneously.

Studies of Chinese Original Quiet Sitting by Using Functional Magnetic Resonance Imaging

Since different meditations may activate different regions in brain, we can use functional magnetic resonance imaging (fMRI) to investigate it. Chinese original quiet sitting is mainly one kind of traditional Chinese meditation. It contains two different parts: a short period of keeping phrase and intake spiritual energy, and a long period of relaxation with no further action. In this paper, both those two stages were studied by fMRI. We performed two different paradigms and found the accurate positions in the brain. The pineal gland and the hypothalamus showed positive activation during the first and second stages of this meditation. The BOLD (blood oxygenation level dependent) signal changes had also been found

Comparison of fMRI BOLD Effect and Arterial Pulsation Harmonic Distribution among Different Breathing Rate

The phenomenon of respiratory sinus arrhythmia (RSA) had been studied since 1733. Most researches were focused on the heart rates or blood pressure variability. It was well known that heart rate variability (HRV) induced by respiration decreased progressively with age. In general, it is caused by the function of the autonomic nervous system (ANS). Seldom researches studied the relationship of this phenomenon with cerebral circulation. In our previous research, we found that different breathing rate could redistribute the proportion of systemic circulation, and also observed that the slower the breathing rate the more proportion of cerebral circulation appeared on head. In this paper, we further examined the BOLD (Blood Oxygenation Level Dependent) signal fluctuations in brain stem among different breathing rate by the technique of functional magnetic resonance imaging (fMRI). We found that the BOLD signal changes were hinged on the breathing rate, and the variability was consistent with the pulsatile pressure study.

Low Level Laser Stimulation of K1 Acupoint Induced Precuneus Activations

This study aims to explore the acupuncture elict activity in specific brain area using low level laser. We investigated the cerebral effects of laser acupuncture at acupoint K1 with functional magnetic resonance imaging (fMRI). After group analysis, we find the significant activation area is on the Precuneus which concern with a wide spectrum of high intergrated tasks.

Buddhist Meditation: An fMRI Study

Since different meditation methods may activate different regions in brain. In this study we chose a basic meditation type that just practiced the breath with the phrase that contained nine words, and the first word was matched with inhaling and following the next with exhaling alternately during the meditation period. Blood-oxygenation-level-dependent (BOLD) based fMRI were used to examine the brain functions. Experiments showed brain activation areas on the region of thalamus, anterior cingulate, posterior cingulate, middle temporal gyrus, as well as putamen and other activations. It displayed that meditation practice concerned with cognitive functions, however, hypothalamus could be activated during meditation practice, and that might be related with endocrine secretion. But it requires further researches combined BOLD-and CBF-based fMRI technique and physiological signal detection simultaneously to explore the mechanism of meditation.

Forced and Non-forced Chinese Meditation Studies

There exist many different types of meditation. The mechanism why meditation improves people’s health remains unclear. Since different meditations may activate different regions in brain, we can use functional magnetic resonance imaging (fMRI) to investigate it. We may simply divide meditation into two different types, which is forced meditation (FM) and non-forced meditation (NFM). The FM type may keep a phrase in mind, observe breathing, proceed mind imaging or any other actions to keep people’s attention focused. Chinese original quiet sitting (COQS) is mainly one kind of traditional Chinese meditation. It contains two different parts: a short period of keeping phrase and receiving spiritual energy, and a long period of relaxation with no further action. The second part of it is really what we called “non-forced” type, whereas the first part is normally a forced one. In this paper, we want to find out the brain activation area precisely during FM and NFM. We studied the observing breathing meditation (OBM) and the first part of COQS as the FM type, and also studied the second part of COQS as NFM type. Our experimental results showed very different activation patterns among the brain between FM and NFM. The BOLD (Blood Oxygenation Level Dependent) signal changes had also been found. The posterior cingulated gyrus showed strong activation in OBM, the pineal gland and hypothalamus showed positive activation in the first and second stage of COQS separately. From our results, we found the basic meaning of the mechanism why meditation improves people’s health.