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Dive into the research topics where Charlene H.L. Wong is active.

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Featured researches published by Charlene H.L. Wong.


Scientific Reports | 2017

Acupuncture and related therapies used as add-on or alternative to prokinetics for functional dyspepsia: overview of systematic reviews and network meta-analysis

Robin S.T. Ho; Vincent C.H. Chung; Charlene H.L. Wong; Justin C. Wu; Samuel Y.S. Wong; Irene X. Y. Wu

Prokinetics for functional dyspepsia (FD) have relatively higher number needed to treat values. Acupuncture and related therapies could be used as add-on or alternative. An overview of systematic reviews (SRs) and network meta-analyses (NMA) were performed to evaluate the comparative effectiveness of different acupuncture and related therapies. We conducted a comprehensive literature search for SRs of randomized controlled trials (RCTs) in eight international and Chinese databases. Data from eligible RCTs were extracted for random effect pairwise meta-analyses. NMA was used to explore the most effective treatment among acupuncture and related therapies used alone or as add-on to prokinetics, compared to prokinetics alone. From five SRs, 22 RCTs assessing various acupuncture and related therapies were included. No serious adverse events were reported. Two pairwise meta-analyses showed manual acupuncture has marginally stronger effect in alleviating global FD symptoms, compared to domperidone or itopride. Results from NMA showed combination of manual acupuncture and clebopride has the highest probability in alleviating patient reported global FD symptom. Combination of manual acupuncture and clebopride has the highest probability of being the most effective treatment for FD symptoms. Patients who are contraindicated for prokinetics may use manual acupuncture or moxibustion as alternative. Future confirmatory comparative effectiveness trials should compare clebopride add-on manual acupuncture with domperidone add-on manual acupuncture and moxibustion.


European Journal of Endocrinology | 2016

Epidemiological characteristics and methodological quality of meta-analyses on diabetes mellitus treatment: a systematic review

Xin Yin Wu; Victor C K Lam; Yue Feng Yu; Robin S.T. Ho; Ye Feng; Charlene H.L. Wong; Benjamin H. K. Yip; Kelvin K.F. Tsoi; Samuel Y.S. Wong; Vincent C.H. Chung

OBJECTIVE Well-conducted meta-analyses (MAs) are considered as one of the best sources of clinical evidence for treatment decision. MA with methodological flaws may introduce bias and mislead evidence users. The aim of this study is to investigate the characteristics and methodological quality of MAs on diabetes mellitus (DM) treatments. DESIGN Systematic review. METHODS Cochrane Database of Systematic Review and Database of Abstract of Reviews of Effects were searched for relevant MAs. Assessing methodological quality of systematic reviews (AMSTAR) tool was used to evaluate the methodological quality of included MAs. Logistic regression analysis was used to identify association between characteristics of MA and AMSTAR results. RESULTS A total of 252 MAs including 4999 primary studies and 13,577,025 patients were included. Over half of the MAs (65.1%) only included type 2 DM patients and 160 MAs (63.5%) focused on pharmacological treatments. About 89.7% MAs performed comprehensive literature search and 89.3% provided characteristics of included studies. Included MAs generally had poor performance on the remaining AMSTAR items, especially in assessing publication bias (39.3%), providing lists of studies (19.0%) and declaring source of support comprehensively (7.5%). Only 62.7% MAs mentioned about harm of interventions. MAs with corresponding author from Asia performed less well in providing MA protocol than those from Europe. CONCLUSIONS Methodological quality of MA on DM treatments was unsatisfactory. There is considerable room for improvement, especially in assessing publication bias, providing lists of studies and declaring source of support comprehensively. Also, there is an urgent need for MA authors to report treatment harm comprehensively.


Therapeutic Advances in Gastroenterology | 2018

Chinese herbal medicine for functional dyspepsia: systematic review of systematic reviews

Michael H. K. Chu; Irene X. Y. Wu; Robin S.T. Ho; Charlene H.L. Wong; Anthony L. Zhang; Yan Zhang; Justin C. Wu; Vincent C.H. Chung

Background: Pharmacotherapy, including prokinetics and proton pump inhibitors for functional dyspepsia (FD) have limited effectiveness, and their safety has been recently questioned. Chinese herbal medicine (CHM) could be considered as an alternative. A systematic review (SR) of SRs was performed to evaluate the potential effectiveness and safety of CHM. Method: We conducted a comprehensive literature search for SRs with meta-analyses in eight international and Chinese databases. Pooled effect estimation from each meta-analysis was extracted. The AMSTAR instrument was used to assess the methodological quality of the included SRs. Results: A total of 14 SRs of mediocre quality assessing various CHMs, alone or in combination with conventional pharmacotherapy, were included. Meta-analyses showed that CHM was more effective than prokinetic agents for the alleviation of global dyspeptic symptoms. Three specific CHM formulae appeared to show superior results in the alleviation of global dyspeptic symptoms, including Si Ni San, modified Xiao Yao San and Xiang Sha Liu Jun Zi decoction. No significant difference in the occurrence of adverse events in using CHM or pharmacotherapy was reported. Conclusion: CHM can be considered as an alternative for the treatment of FD symptoms when prokinetic agents and proton pump inhibitors are contraindicated. Future trial design should focus on measuring changes in individual dyspeptic symptoms and differentiate the effectiveness of different CHM for postprandial distress syndrome and epigastric pain syndrome. A network meta-analysis approach should be used to explore the most promising CHM formula for FD treatment in the future.


BMJ Open | 2018

Electroacupuncture plus standard of care for managing refractory functional dyspepsia: protocol of a pragmatic trial with economic evaluation

Vincent C.H. Chung; Charlene H.L. Wong; Jessica Ching; Wai Zhu Sun; Yan Li Ju; Sheung Sheung Hung; Wai Ling Lin; Ka Chun Leung; Samuel Y. S. Wong; Justin C. Wu

Introduction This trial proposes to compare the effectiveness and cost-effectiveness of electroacupuncture (EA) plus on-demand gastrocaine with waiting list for EA plus on-demand gastrocaine in providing symptom relief and quality-of-life improvement among patients with functional dyspepsia (FD). Methods and analysis This is a single-centre, pragmatic, randomised parallel-group, superiority trial comparing the outcomes of (1) EA plus on-demand gastrocaine group and (2) waiting list to EA plus on-demand gastrocaine group. 132 (66/arm) endoscopically confirmed, Helicobacter pylori-negative patients with FD will be recruited. Enrolled patients will respectively be receiving (1) 20 sessions of EA over 10 weeks plus on-demand gastrocaine; or (2) on-demand gastrocaine and being nominated on to a waiting list for EA, which entitles them 20 sessions of EA over 10 weeks after 12 weeks of waiting. The primary outcome will be the between-group difference in proportion of patients achieving adequate relief of symptoms over 12 weeks. The secondary outcomes will include patient-reported change in global symptoms and individual symptoms, Nepean Dyspepsia Index, Nutrient Drink Test, 9-item Patient Health Questionnaire (PHQ9), and 7-item Generalised Anxiety Disorder Scale (GAD7). Adverse events will be assessed formally. Results on direct medical costs and on the EuroQol (EQ-5D) questionnaire will also be used to assess cost-effectiveness. Analysis will follow the intention-to-treat principle using appropriate univariate and multivariate methods. A mixed model analysis taking into account missing data of these outcomes will be performed. Cost-effectiveness analysis will be performed using established approach. Ethics and dissemination The study is supported by the Health and Medical Research Fund, Government of the Hong Kong Special Administrative Region of China. It has been approved by the Joint Chinese University of Hong Kong – New Territories East Cluster Clinical Research Ethics Committee. Results will be published in peer-reviewed journals and be disseminated in international conference. Trial registration number ChiCTR-IPC-15007109; Pre-result.


Advances in integrative medicine | 2016

Should Tai Chi be part of cardiac rehabilitation programme for patients with chronic heart failure

Charlene H.L. Wong; Jasmine T.M. Chow; Vincent C.H. Chung


Advances in integrative medicine | 2016

Is Tian Jiu Therapy effective in reducing asthma symptoms

Jasmine T.M. Chow; Charlene H.L. Wong; Vincent C.H. Chung


Advances in integrative medicine | 2015

Medical synopsis: Can acupuncture be an alternative treatment option for patients with refractory functional dyspepsia?

Robin S.T. Ho; Charlene H.L. Wong; Vincent C.H. Chung


European Journal of Integrative Medicine | 2018

CHIMERAS showed better inter-rater reliability and inter-consensus reliability than GRADE in grading quality of evidence: A randomized controlled trial

Xin Yin Wu; Vincent C.H. Chung; Charlene H.L. Wong; Benjamin H. K. Yip; William K.W. Cheung; Justin C. Wu


Advances in integrative medicine | 2017

Is manual acupuncture effective in reducing overactive bladder symptoms among female adults as compared to oral tolterodine tartrate

Charlene H.L. Wong; Jasmine T.M. Chow; Vincent C.H. Chung


Advances in integrative medicine | 2017

Is individualised Chinese herbal formula effective in treating oligomenorrhoea and amenorrhoea among female with polycystic ovary syndrome as compared to standardised Chinese herbal formula

Charlene H.L. Wong; William K.W. Cheung; Vincent C.H. Chung

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Vincent C.H. Chung

The Chinese University of Hong Kong

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Justin C. Wu

The Chinese University of Hong Kong

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Robin S.T. Ho

The Chinese University of Hong Kong

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Jasmine T.M. Chow

The Chinese University of Hong Kong

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Xin Yin Wu

The Chinese University of Hong Kong

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Benjamin H. K. Yip

The Chinese University of Hong Kong

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Irene X. Y. Wu

The Chinese University of Hong Kong

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Samuel Y.S. Wong

The Chinese University of Hong Kong

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William K.W. Cheung

The Chinese University of Hong Kong

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Jessica Ching

The Chinese University of Hong Kong

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