Charles D. Noonan

Histologic type-specific vascular patterns in rat tumors

There has been some debate as to whether the vascular pattern of a tumor reflects its histology or that of the stroma of its tissue of origin and also whether the vascular pattern of a metastasis imitates the pattern of its primary lesion. To study these questions, the authors transplanted a Walker 256 sarcoma and a fibrosarcoma into 70 rats and successfully induced pulmonary metastases in 30 of these. The circulation of both the primaries and the metastases was then studied by “lethal” microangiography. The study has shown that the vascular pattern does reflect the histology of the tumor itself and not the stroma of its tissue of origin and that metastatic tumors do not have the same circulatory pattern as their primary tumor.

Bronchial Arterial Patterns in Pulmonary Metastasis

Bronchial arteriography in vivo is now Ban accepted study in man (6), and various methods have been reported (2, 6, 7, 9, 10). The examination is of value and interest in congenital and acquired heart disease, in anomalies of blood supply to the lung, in chronic lung disease such as bronchiectasis, and in the determination of tumor vascularity. The method provides a direct avenue for treatment with chemotherapeutic agents. This report concerns the bronchial vascular pattern of metastatic lesions in specimens of human lungs and evaluates direct 10 × photographic enlargements (decaarteriography) of these vascular patterns. Anatomy Galen was the first to describe the bronchial arteries, but not until the nineteenth century was more interest given to the systemic circulation of the lung. In 1948, Cauldwell and his co-workers (1) described variations of the normal bronchial arteries in 150 cadavers. In their series, the variants of the arteries that commonly arise from the thoracic aorta at the level of the fi...

Effect of Timed Occlusions at Various Levels of Mesenteric Arteries and Veins: Correlative Study of Arteriographic and Histologic Patterns of Rat Gut

Vascular disease of the small and large intestine has been of interest to the medical profession for many years. In recent years, as more examples of such disease are recognized, it has assumed even greater importance. The disease has been investigated by means of plain and barium sulfate roentgenograms and by arteriography. The results of these studies have been reported by many authors, including Nelson and Eggleston (5), Schwartz et al. (6, 7), Wang and Reeves (8), and Wolf and Marshak (9). Experimental studies of human and canine mesenteric vascular disease have also been reported (1, 2, 6, 7). With advances in diagnostic arteriography and the introduction of the Seldinger technic, selective catheterization of mesenteric vessels became practical. To our knowledge, however, no systematic experiments have been reported which correlate the histologic and arteriographic patterns of bowel in occlusive disease of the superior mesenteric vessels. In the studies reported here, the histologic changes are compa...

Radiographic Evaluation of Total Hip Arthroplasty

The radiographic appearance of normal and abnormal total hip arthroplasties are compared and discussed. Radiographic signs are presented which can lead to early clinical detection of mechanical failure. Arthrography or radiography of sinus tracts is necessary to evaluate the lack of physical bonding by the acrylic cement and the extent of local infection.The radiographic appearance of normal and abnormal total hip arthroplasties are compared and discussed. Radiographic signs are presented which can lead to early clinical detection of mechanical failure. Arthrography or radiography of sinus tracts is necessary to evaluate the lack of physical bonding by the acrylic cement and the extent of local infection.

Antenatal diagnosis of achondroplasia with comment on Deuel's “halo” sign

Abstract Achondroplasia is a hereditary, congenital, skeletal dystrophy and, possibly, a generalized disorder of connective tissue limited to bone. Its intrauterine roentgenographic manifestations in both a normal and an achondroplastic mother are presented. Deuels “halo” sign which indicated impending fetal death that occurred shortly after parturition, was observed in one case.

Effect of biopsy and other trauma on transplanted lymphosarcoma in mice.

Abstract The effects of preimplantation fracture and postimplantation biopsy upon the growth of lymphosarcomas implanted in mice, as well as host survival, were studied. The host survival time depended upon inoculum size; preimplantation fracture resulted in earlier mortality, as did postimplantation biopsy unless followed by irradiation. The effects are believed to be local rather than systemic.

Angiographic evaluation of the effect of trauma and irradiation on transplanted lymphosarcoma in mice.

Cancer research is principally directed to various aspects of the malignant cell. Yet the nature of the supporting matrix, including the vasculature, may importantly influence tumor growth and response to therapeutic agents. Merwin, Algire, and Kaplan (4) and Vermund (5) demonstrated that prior irradiation to the site of implantation will retard growth of a transplanted tumor. Presumably such irradiation impairs capillary sprouting. The purpose of the present study is to evaluate various factors that may modify the vascular response to tumor implantation. Some of the factors are thought to stimulate vascularization whereas others are known to depress it. Vascular patterns were studied angiographically, and the effects on tumor growth were evaluated from host survival. Material and Method A lymphosarcoma 6C3HED and virgin C3H/HEJ female mice weighing 15 to 20 g were obtained from the Jackson Laboratory. The tumor was maintained in both solid and ascitic form by biweekly passage. After appropriate dilution ...