Charles H. Zeanah

Growth and Associations Between Auxology, Caregiving Environment, and Cognition in Socially Deprived Romanian Children Randomized to Foster vs Ongoing Institutional Care

OBJECTIVESnTo determine effects of improved nurturing compared with institutional care on physical growth and to investigate the association between growth and cognitive development.nnnDESIGNnA randomized controlled trial beginning in infants (mean age, 21.0 months; range, 5-32 months), with follow-up at 30, 42, and 54 months of age.nnnSETTINGnInstitutionalized and community children in Bucharest, Romania.nnnPARTICIPANTSnOne hundred thirty-six healthy institutionalized children from 6 orphanages and 72 typically developing, never-institutionalized children.nnnINTERVENTIONnInstitutionalized children were randomly assigned to receive foster care or institutional care as usual.nnnOUTCOME MEASURESnAuxology and measures of intelligence over time.nnnRESULTSnGrowth in institutionalized children was compromised, particularly in infants weighing less than 2500 g at birth. Mean height and weight, though not head size, increased to near normal within 12 months in foster care. Significant independent predictors for greater catch-up in height and weight included age younger than 12 months at randomization, lower baseline z scores, and higher caregiving quality, particularly caregiver sensitivity and positive regard. Baseline developmental quotient, birth weight, and height catch-up were significant independent predictors of cognitive abilities at follow-up. Each incremental increase of 1 in standardized height scores between baseline and 42 months was associated with a mean increase of 12.6 points (SD, 4.7 points) in verbal IQ (P < .05).nnnCONCLUSIONSnFoster care had a significant effect on growth, particularly with early placement and high-quality care. Growth and IQ in low-birth-weight children are particularly vulnerable to social deprivation. Catch-up growth in height under more nurturing conditions is a useful indicator of caregiving quality and cognitive improvement.