Charles Hill

The Notch Regulator Numb Links the Notch and TCR Signaling Pathways

Both the Notch and TCR signaling pathways play an important role in T cell development, but the links between these signaling pathways are largely unexplored. The adapter protein Numb is a well-characterized inhibitor of Notch and also contains a phosphotyrosine binding domain, suggesting that Numb could provide a link between these pathways. We explored this possibility by investigating the physical interactions among Notch, Numb, and the TCR signaling apparatus and by examining the consequences of a Numb mutation on T cell development. We found that Notch and Numb cocluster with the TCR at the APC contact during Ag-driven T cell-APC interactions in both immature and mature T cells. Furthermore, Numb coimmunoprecipitates with components of the TCR signaling apparatus. Despite this association, T cell development and T cell activation occur normally in the absence of Numb, perhaps due to the expression of the related protein, Numblike. Together our data suggest that Notch and TCR signals may be integrated at the cell membrane, and that Numb may be an important adapter in this process.

POLARBEAR constraints on cosmic birefringence and primordial magnetic fields

Author(s): Ade, PAR; Arnold, K; Atlas, M; Baccigalupi, C; Barron, D; Boettger, D; Borrill, J; Chapman, S; Chinone, Y; Cukierman, A; Dobbs, M; Ducout, A; Dunner, R; Elleflot, T; Errard, J; Fabbian, G; Feeney, S; Feng, C; Gilbert, A; Goeckner-Wald, N; Groh, J; Hall, G; Halverson, NW; Hasegawa, M; Hattori, K; Hazumi, M; Hill, C; Holzapfel, WL; Hori, Y; Howe, L; Inoue, Y; Jaehnig, GC; Jaffe, AH; Jeong, O; Katayama, N; Kaufman, JP; Keating, B; Kermish, Z; Keskitalo, R; Kisner, T; Kusaka, A; Le Jeune, M; Lee, AT; Leitch, EM; Leon, D; Li, Y; Linder, E; Lowry, L; Matsuda, F; Matsumura, T; Miller, N; Montgomery, J; Myers, MJ; Navaroli, M; Nishino, H; Okamura, T; Paar, H; Peloton, J; Pogosian, L; Poletti, D; Puglisi, G; Raum, C; Rebeiz, G; Reichardt, CL; Richards, PL; Ross, C; Rotermund, KM; Schenck, DE; Sherwin, BD; Shimon, M; Shirley, I; Siritanasak, P; Smecher, G; Stebor, N; Steinbach, B; Suzuki, A; Suzuki, JI; Tajima, O; Takakura, S; Tikhomirov, A; Tomaru, T; Whitehorn, N; Wilson, B; Yadav, A; Zahn, A | Abstract:

POLARBEAR-2: An instrument for CMB polarization measurements

POLARBEAR-2 (PB-2) is a cosmic microwave background (CMB) polarization experiment that will be located in the Atacama highland in Chile at an altitude of 5200 m. Its science goals are to measure the CMB polarization signals originating from both primordial gravitational waves and weak lensing. PB-2 is designed to measure the tensor to scalar ratio, r, with precision σ(r) > 0:01, and the sum of neutrino masses, Σmz, with σ(Σmv) < 90 meV. To achieve these goals, PB-2 will employ 7588 transition-edge sensor bolometers at 95 GHz and 150 GHz, which will be operated at the base temperature of 250 mK. Science observations will begin in 2017.

Performance of a continuously rotating half-wave plate on the POLARBEAR telescope

National Science Foundation AST-0618398 AST-1212230 Comision Nacional de Investigacion Cientifica y Tecnologica de Chile (CONICYT) Office of Science of the U.S. Department of Energy DE-AC02-05CH11231 MEXT KAKENHI Grant JP15H05891 21111002 JSPS KAKENHI Grant JP26220709 JP24111715 JSPS Core-to-Core Program RADIOFOREGROUNDS grant of the European Unions Horizon research and innovation programme (COMPET) 687312 INDARK INFN Initiative CONICYTs UC Berkeley-Chile Seed Grant (CLAS fund) 77047 Fondecyt 1130777 DFI postgraduate scholarship program DFI Postgraduate Competitive Fund for Support in the Attendance to Scientific Events NSF AST-1501422 CNES postdoctoral program Science and Technology Facilities Council ST/L000652/1 European Research Council under the European Unions Seventh Framework Programme (FP) / ERC Grant 616170 Australian Research Councils Future Fellowship FT150100074 hp150132

The Simons Array CMB polarization experiment

The Simons Array is a next generation cosmic microwave background (CMB) polarization experiment whose science target is a precision measurement of the B-mode polarization pattern produced both by inflation and by gravitational lensing. As a continuation and extension of the successful POLARBEAR experimental program, the Simons Array will consist of three cryogenic receivers each featuring multichroic bolometer arrays mounted onto separate 3.5m telescopes. The first of these, also called POLARBEAR-2A, will be the first to deploy in late 2016 and has a large diameter focal plane consisting of dual-polarization dichroic pixels sensitive at 95 GHz and 150 GHz. The POLARBEAR-2A focal plane will utilize 7,588 antenna-coupled superconducting transition edge sensor (TES) bolometers read out with SQUID amplifiers using frequency domain multiplexing techniques. The next two receivers that will make up the Simons Array will be nearly identical in overall design but will feature extended frequency capability. The combination of high sensitivity, multichroic frequency coverage and large sky area available from our mid-latitude Chilean observatory will allow Simons Array to produce high quality polarization sky maps over a wide range of angular scales and to separate out the CMB B-modes from other astrophysical sources with high fidelity. After accounting for galactic foreground separation, the Simons Array will detect the primordial gravitational wave B-mode signal to r > 0.01 with a significance of > 5σ and will constrain the sum of neutrino masses to 40 meV (1σ) when cross-correlated with galaxy surveys. We present the current status of this funded experiment, its future, and discuss its projected science return.

Modeling atmospheric emission for CMB ground-based observations

Atmosphere is one of the most important noise sources for ground-based cosmic microwave background (CMB) experiments. By increasing optical loading on the detectors, it amplifies their effective noise, while its fluctuations introduce spatial and temporal correlations between detected signals. We present a physically motivated 3d-model of the atmosphere total intensity emission in the millimeter and sub-millimeter wavelengths. We derive a new analytical estimate for the correlation between detectors time-ordered data as a function of the instrument and survey design, as well as several atmospheric parameters such as wind, relative humidity, temperature and turbulence characteristics. Using an original numerical computation, we examine the effect of each physical parameter on the correlations in the time series of a given experiment. We then use a parametric-likelihood approach to validate the modeling and estimate atmosphere parameters from the POLARBEAR-I project first season data set. We derive a new 1.0% upper limit on the linear polarization fraction of atmospheric emission. We also compare our results to previous studies and weather station measurements. The proposed model can be used for realistic simulations of future ground-based CMB observations.

Making maps of cosmic microwave background polarization for B-mode studies: the POLARBEAR example

Analysis of cosmic microwave background (CMB) datasets typically requires some filtering of the raw time-ordered data. For instance, in the context of ground-based observations, filtering is frequently used to minimize the impact of low frequency noise, atmospheric contributions and/or scan synchronous signals on the resulting maps. In this work we have explicitly constructed a general filtering operator, which can unambiguously remove any set of unwanted modes in the data, and then amend the map-making procedure in order to incorporate and correct for it. We show that such an approach is mathematically equivalent to the solution of a problem in which the sky signal and unwanted modes are estimated simultaneously and the latter are marginalized over. We investigated the conditions under which this amended map-making procedure can render an unbiased estimate of the sky signal in realistic circumstances. We then discuss the potential implications of these observations on the choice of map-making and power spectrum estimation approaches in the context of B-mode polarization studies. Specifically, we have studied the effects of time-domain filtering on the noise correlation structure in the map domain, as well as impact it may haveon the performance of the popular pseudo-spectrum estimators. We conclude that although maps produced by the proposed estimators arguably provide the most faithful representation of the sky possible given the data, they may not straightforwardly lead to the best constraints on the power spectra of the underlying sky signal and special care may need to be taken to ensure this is the case. By contrast, simplified map-makers which do not explicitly correct for time-domain filtering, but leave it to subsequent steps in the data analysis, may perform equally well and be easier and faster to implement. We focused on polarization-sensitive measurements targeting the B-mode component of the CMB signal and apply the proposed methods to realistic simulations based on characteristics of an actual CMB polarization experiment, POLARBEAR. Our analysis and conclusions are however more generally applicable.

Systematic uncertainties in the Simons Observatory: optical effects and sensitivity considerations

The Simons Observatory (SO) is a new experiment that aims to measure the cosmic microwave background (CMB) in temperature and polarization. SO will measure the polarized sky over a large range of microwave frequencies and angular scales using a combination of small (~0.5 m) and large (~6 m) aperture telescopes and will be located in the Atacama Desert in Chile. This work is part of a series of papers studying calibration, sensitivity, and systematic errors for SO. In this paper, we discuss current efforts to model optical systematic effects, how these have been used to guide the design of the SO instrument, and how these studies can be used to inform instrument design of future experiments like CMB-S4. While optical systematics studies are underway for both the small aperture and large aperture telescopes, we limit the focus of this paper to the more mature large aperture telescope design for which our studies include: pointing errors, optical distortions, beam ellipticity, cross-polar response, instrumental polarization rotation and various forms of sidelobe pickup.