Charles J. Gardner
Rhône-Poulenc
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Featured researches published by Charles J. Gardner.
Bioorganic & Medicinal Chemistry Letters | 1996
Scott I. Klein; Jeffrey Mark Dener; Bruce F. Molino; Charles J. Gardner; Rose D'Alisa; Christopher T. Dunwiddie; Charles Kasiewski; Robert Leadley
Abstract A series of analogs were prepared based on the known thrombin inhibitor PPACK, in which the D-Phe-Pro dipeptide has been replaced by trans-4-O-benzyl hydroxyproline. One of these analogs is a more potent inhibitor of thrombin, and is more selective, than PPACK itself.
Bioorganic & Medicinal Chemistry Letters | 2011
Lan Mu; Joacy C. Aguiar; Ali Ardati; Bin Cao; Charles J. Gardner; Tim Gillespy; Keith John Harris; Sungtaek Lim; Robert Marcus; Isabelle Morize; Ashfaq Parkar; David Stefany; Yi Li; Roy J. Vaz; Dragan A. Cirovic
A Comparative Molecular Similarity Indices Analysis (CoMSIA) was performed for 2,6-substituted-4-monosubstituted aminopyrimidine antagonists of prostaglandin D(2) receptor (DP). Both two-component (Q(2) = 0.63, R(2) = 0.82, SEE = 0.47 pIC(50)) and three-component (Q(2) = 0.70, R(2) = 0.91, SEE = 0.36 pIC(50)) CoMSIA models were established. Two hydrogen-bond acceptors with spatial separation of about 8Å are shown as optimal for binding. A large hydrophobic center that separates the two acceptors confers to the potency of the 2,6-substituted-4-monosubstituted aminopyrimidine. The models were used to predict IC(50) values for compounds which had functional groups different from those in the training set.
Journal of Medicinal Chemistry | 2003
Yong Mi Choi-Sledeski; Robert E. Kearney; Gregory Bernard Poli; Henry W. Pauls; Charles J. Gardner; Yong Gong; Michael Becker; Roderick S. Davis; Alfred P. Spada; Guyan Liang; Valeria Chu; Karen A. Brown; Dennis Collussi; Robert J. Leadley; Sam Rebello; Phillip Moxey; Suzanne R. Morgan; Ross Bentley; Charles Kasiewski; Sébastien Maignan; Jean-Pierre Guilloteau; Vincent Mikol
Archive | 1990
Scott I. Klein; Bruce F. Molino; Mark Czekaj; Charles J. Gardner; Jeffrey C. Pelletier
Journal of Medicinal Chemistry | 1998
Scott I. Klein; Mark Czekaj; Charles J. Gardner; Kevin Richard Guertin; Daniel L. Cheney; Alfred P. Spada; Scott A. Bolton; Karen A. Brown; Dennis Colussi; Christopher L. Heran; Suzanne R. Morgan; Robert J. Leadley; Christopher T. Dunwiddie; Mark H. Perrone; Valeria Chu
Journal of Medicinal Chemistry | 1998
Scott I. Klein; Bruce F. Molino; Mark Czekaj; Charles J. Gardner; Valeria Chu; Karen A. Brown; Ralph Sabatino; Jeffrey S. Bostwick; Charles Kasiewski; Ross Bentley; Vincent Windisch; Mark H. Perrone; Christopher T. Dunwiddie; Robert J. Leadley
Archive | 1994
Scott I. Klein; Bruce F. Molino; Mark Czekaj; Charles J. Gardner
Archive | 2007
David Stefany; Keith John Harris; Timothy A. Gillespy; Charles J. Gardner; Joacy C. Aguiar
Archive | 2004
Paul Joseph Cox; Tahir Nadeem Majid; Justine Lai; Andrew David Morley; Shelley Amendola; Stéphanie Deprets; Christopher David Edlin; Charles J. Gardner; Dorothea Kominos; Brian Pedgrift; Frank Halley; Timothy A. Gillespy; Michael Edwards; François Clerc; Conception Nemecek; Olivier Houille; Dominique Damour; Herve Bouchard; Daniel Bézard; Chantal Carrez
Archive | 2010
Yong Mi Choi-Sledeski; Charles J. Gardner; Guyan Liang; Gregory Bernard Poli; Patrick Wai-Kwok Shum; Grzegory T. Stoklosa; Zhicheng Zhao