Charles Rc Marks

Differential effects of exercise training in men and women with chronic heart failure

BACKGROUNDnAbnormalities of myosin heavy chain (MHC) isoforms, enzyme activity, and capillarity contribute to the exercise intolerance that is characteristic of patients with heart failure. To what extent these changes can be reversed with exercise training and whether differences exist in the responses of men and women remains uncertain. We described and compared the effects of exercise training on exercise capacity and skeletal muscle histochemistry in men and women with chronic heart failure.nnnMETHODSnFifteen patients (10 male) undergoing standard medical therapy completed a 14- to 24-week exercise training program. Peak oxygen consumption, MHC isoforms, capillary density, and selected metabolic enzymes were assessed before and after training.nnnRESULTSnPeak oxygen consumption was improved 14% (P <.05); however, this increase was mostly because of the improvement observed in men versus women (+20% versus +2%, respectively, P <.01). At baseline, MHC I content was lower in men than in women (33% +/- 3% vs 49.6% +/- 5.5%, P <.05). MHC I improved with training in men, to 45.6% +/- 4.5% (+38%, P <.05), versus women (-3%, P =.82), and the increase in men tended (P =.12) to be significant when compared with that in women. There were no significant changes in capillary density or muscle enzyme activity with training in the group as a whole or in men and women separately.nnnCONCLUSIONnAmong patients with chronic heart failure, improvements in peak exercise capacity may be more pronounced in men than in women. This difference in response of functional capacity to training paralleled differences observed between men and women for changes in MHC I isoforms.

Physiologic responses to recumbent versus upright cycle ergometry, and implications for exercise prescription in patients with coronary artery disease

To clarify the influence of body position on exercise prescription, 14 men (mean age +/- standard deviation 60.0 +/- 6.1 years) with coronary artery disease who underwent randomized recumbent and upright cycle ergometer tests to volitional fatigue were studied. At 100 watts, heart rate (HR), systolic blood pressure, oxygen consumption (VO2), rate pressure product and rating of perceived exertion were greater (p less than 0.05) in the upright than in the recumbent position. At peak exercise, however, these variables were not significantly different. Regressions of relative HR versus VO2 for recumbent and upright cycle ergometry were comparable: y = 1.24x - 32.7 and y = 1.26x - 31.5, respectively, where y = % maximal VO2, and x = % maximal HR. These findings indicate that recumbent exercise prescriptions may be based on the peak HR and VO2 values obtained during upright cycle ergometry, and vice versa. However, differences in the cardiorespiratory responses at submaximal exercise preclude the interchangeability of upright and recumbent training work rates.

Cardiovascular responses of cardiac transplant patients to arm and leg exercise

AbstractThis investigation compares the cardiovascular responses of normal (n=10) and cardiac transplant (n=14) subjects to peak arm and leg exercise. It also tests the hypothesis that the higher heart rate (fc) in normal subjects during light (30 W) submaximal arm versus leg exercise is due to cardiac innervation. In cardiac transplant patients, power output, oxygen consumptionn

Cardiovascular responses to submaximal arm and leg exercise in cardiac transplant patients.

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Stability Ball Sitting Elevates Peak Arm Ergometry Oxygen Consumption and Heart Rate.

n,fc and rate pressure product were 54%, 28%, 7%, and 8% lower during peak arm than leg exercise, respectively. In normal subjects, power output,n

Cardiometabolic Risk Factors, Muscular Fitness, and Cardiorespiratory Fitness in Apparently Healthy Young Adult Females: 2477 Board #1 June 1 1

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