Charlotte E. Ruse

Associations Between Polymorphisms of the High-Affinity Immunoglobulin E Receptor and Late-Onset Airflow Obstruction in Older Populations

Objectives: To test the hypothesis that genetic polymorphisms in the β subunit of the high‐affinity immunoglobulin E (IgE) receptor are associated with late‐onset airflow obstruction.

Associations Between Polymorphisms of the High-Affinity Immunoglobulin E Receptor and Late-Onset Airflow Obstruction in Older Populations: IMMUNOGLOBULIN E RECEPTOR POLYMORPHISMS IN OLDER POPULATIONS

Objectives: To test the hypothesis that genetic polymorphisms in the β subunit of the high‐affinity immunoglobulin E (IgE) receptor are associated with late‐onset airflow obstruction.

Association of beta-2-adrenoceptor polymorphisms and pulmonary function in patients with chronic obstructive pulmonary disease

Aims:  The Dutch Hypothesis suggests that asthma and chronic obstructive pulmonary disease may share some pathogenic mechanisms. There is considerable evidence that polymorphisms of the β2 adrenoceptor have disease‐modifying roles in juvenile onset asthma, determining severity and response to β agonists, but not determining disease susceptibility. There is evidence from family and twin studies to suggest that chronic obstructive pulmonary disease (COPD) also has a significant genetic component. We therefore hypothesized that β2 adrenoceptor polymorphisms would have similar disease modifying roles in patients with COPD.

Associations between polymorphisms of the high-affinity immunoglobulin E receptor and late-onset airflow obstruction in older populations

Objectives: To test the hypothesis that genetic polymorphisms in the β subunit of the high‐affinity immunoglobulin E (IgE) receptor are associated with late‐onset airflow obstruction.

Venous thrombosis in older people: prevalence of the factor V gene mutation Q506.

time sleepiness was related to BMI, high blood pressure, and depressive symptomatology, but not to psychotropic drugs. All analyses were adjusted for age, gender, educational level, BMI, high blood pressure, and initial value of the MMSE. The possible confounding effect of alcohol consumption and depressive symptoms was also taken into account. A total of 184 subjects (16%) had a decrease in MMSE score of 3 points or more between baseline and 4-year follow up examinations. Longitudinal analyses showed that snorers had an increased risk of cognitive decline compared with non-snorers (OR = 1.36; 95% CI, 0.97-1.92); a similar trend was found for excessive daytime sleepiness (OR = 1.33; 95%