Charlotte P. McLeod

Spirocheticidal activity of plasma and serum fractions.

Summary There is no appreciable difference between the spirocheticidal activity of the serum and the plasma from patients with early syphilis. Serums and plasmas were fractionated into eight precipitates by the application of Cohns Method 10. In the majority of the experiments, more than 50% of the spirocheticidal substances were present in fraction III-1,2 associated with high molecular weight isoagglutinins and small amount of prothrombin protein (and fibrinogen when plasma was employed) and fraction I -f- III-3 associated with the high molecular weight antihemophilic globulin and cold insoluble globulin and a small amount of plasminogen. We wish to thank Miss P. L. Sapp, Miss V. L. McMahan and Mr. D. Shanor for their skillful technical assistance.