Chaturvedula V. S. Prakash

Two new polyhydroxysteroids from the gorgonian Isis hippuris

Two new polyhydroxysteroids isihippurols A (1) and B (2) were isolated from the MeOH extract of the gorgonian Isis hippuris in addition to nine known steroids namely gorgosterol, 3alpha-acetoxy-24-methyl 11beta,18; 18,20beta; 22,25-triepoxy-5alpha-furostane, hippurin-1, 22-epi-hippuristanol, 22-epi-hippurin-1, 3-acetyl-2-deacetyl-22-epi-hippurin-1, 2-deacetylhippurin-1, 3beta, 7alpha, 11alpha-trihydroxygorgost-5-ene-12beta-acetate and 2-deacetyl-22-epi-hippurin-1. The structures of 1 and 2 have been determined as 1alpha, 3beta, 5alpha, 6beta, 11alpha-pentahydroxygorgosta-12beta-monoacetate and 1alpha, 3beta, 11alpha-trihydroxygorgosta-5alpha, 6alpha-epoxy-12beta-monoacetate respectively by spectral analysis and chemical correlation.

Bioactive Steroids from the Formosan Gorgonian Isis Hippuris

Bioassay-directed fractionation has resulted in the isolation of nine steroids namely gorgosterol (1), 3β, 7α, llα-trihydroxygorgost-5-ene-12β-acetate (2), 3α-acetoxy-24-methyl-11β,18; 18,20~; 22,25-triepoxy-5a-furostane (3), hippurin-(4), 2-deacetylhippurin-1 (5), 22-epi-hippurin-1 (6), 3-acetyl-2-deacetyl-22-epi-bippurin-l (7), 2-deacetyl-22-epi-bippurin-l (8) and 22-epi-hippuristanol (9) from the acetone extract of the Formosan gorgonian Isis hippurin, in addition to the orange-red pigment peridinin (10). The structures of these compounds were established on the basis of spectroscopic analysis. Biological studies revealed that compounds 5, 7-9 exhibited potent cytotoxicity against NUGC tumor cell