Cheng Zhe Jin
Ajou University
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Publication
Featured researches published by Cheng Zhe Jin.
Journal of Biomedical Materials Research Part A | 2009
Cheng Zhe Jin; Byung Hyune Choi; So Ra Park; Byoung-Hyun Min
A cell-derived extracellular matrix (ECM) scaffold was constructed using cultured porcine chondrocytes via a freeze-drying method, and its ability to promote cartilage formation was evaluated in vitro. Scanning electron microscope (SEM) revealed that the scaffold had highly uniform porous microstructure. Then, rabbit chondrocytes were seeded dynamically on ECM scaffold and cultured for 2 days, 1, 2, and 4 weeks in vitro for analysis. Polyglycolic acid (PGA) scaffold was used as a control. On gross observation of neocartilage tissue, a silvery white cartilage-like tissue was observed after 1 week of culture in ECM scaffold, while similar morphology was seen only after 4 weeks in PGA scaffold. The volume of neocartilage-like tissue was significantly increased in both ECM and PGA groups. The compressive strength was gradually increased with time in ECM group, while gradually decreased in PGA group. DNA, glycosaminoglycan (GAG) and collagen contents also increased gradually with time in both groups, but showed more significant increase in ECM group. Histological staining for GAG (Safranin O staining) and type II collagen (immunohistochemistry) showed sustained accumulation of ECM molecules with time, which gradually and uniformly filled porous space in ECM scaffold. On the contrary, they accumulated only at the peripheral area of PGA scaffold. These results suggest that a novel cell-derived ECM scaffold can provide a promising environment for generating a high quality cartilage in vitro.
Tissue Engineering | 2007
Cheng Zhe Jin; So Ra Park; Byung Hyune Choi; Kyu-Young Lee; Choong Ku Kang; Byoung-Hyun Min
Artificial Organs | 2007
Cheng Zhe Jin; So Ra Park; Byung Hyune Choi; Kwideok Park; Byoung-Hyun Min
Journal of Trauma-injury Infection and Critical Care | 2006
Cheng Zhe Jin; Hyun-Kon Kim; Byoung-Hyun Min
Tissue Engineering Part A | 2011
Cheng Zhe Jin; Jae-Ho Cho; Byung Hyune Choi; Li Ming Wang; Moon Suk Kim; So Ra Park; Jeong Ho Yoon; Hyun Ju Oh; Byoung-Hyun Min
Ultrasound in Medicine and Biology | 2005
So Ra Park; Kyung Wha Jang; Sang Hyug Park; Hong Sik Cho; Cheng Zhe Jin; Min Joo Choi; Soo Il Chung; Byoung Hyun Min
Advanced Functional Materials | 2012
Tian Zhu Li; Cheng Zhe Jin; Byung Hyune Choi; Moon Suk Kim; Young Jick Kim; So Ra Park; Jeong Ho Yoon; Byoung-Hyun Min
Archive | 2007
Byoung-Hyun Min; So Ra Park; Cheng Zhe Jin; Byung Hyune Choi
Archive | 2007
Byoung-Hyun Min; So Ra Park; Cheng Zhe Jin; Kwideok Park
Archive | 2007
Byoung-Hyun Min; So Ra Park; Cheng Zhe Jin; Kwideok Park