Cheong-Ho Chang

A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast(Ossron™) injection to treat fractures

BackgroundWe performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts.MethodsSixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast injection and those who received no treatment. The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable.ResultsThe autologous cultured osteoblast injection group showed fracture healing acceleration of statistical significance, and there were no specific patient complications when using this treatment.ConclusionAutologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.Trial registrationCurrent Controlled Trials ISRCTN10637905

Treatment of osteonecrosis of the femoral head using autologous cultured osteoblasts: a case report

IntroductionOsteonecrosis of the femoral head is a progressive disease that leads to femoral head collapse and osteoarthritis. Our goal in treating osteonecrosis is to preserve, not to replace, the femoral head.Case presentationWe present the case of a patient with bilateral osteonecrosis of the femoral head treated with autologous cultured osteoblast injection.ConclusionAlthough our experience is limited to one patient, autologous cultured osteoblast transplantation appears to be effective for treating the osteonecrosis of femoral head.

Autologous chondrocyte implantation for rheumatoid arthritis of the knee: a case report

IntroductionAlthough pharmacologic treatment remains the mainstay for treating rheumatoid arthritis, there is an increasing need for a method that biologically regenerates arthritic knee lesions as patient longevity continually increases.Case presentationWe treated rheumatoid arthritis of the right knee in a 35-year-old female Korean patient using autologous chondrocyte implantation. Twelve months after surgery, the patient could walk without pain.ConclusionAutologous chondrocyte implantation appears to be effective for treating rheumatoid arthritis of the knee.

Cartilage Regeneration Using a Fibrin and Autologous Cultured Chondrocytes Mixture in a Canine Model

Background: Various surgical methods have been designed to avoid the necessity of using periosteum, i.e. an operative weak point of autologous chondrocyte implantation (ACI) which is a representative method for treating articular cartilage injury. This study was performed in the attempt to develop a simple, injectable type of ACI to in order facilitate the surgical process. Methods: Seven of 10 dogs were used for the injectable type ACI using fibrin, while the remaining three dogs were used for implantation according to the previous surgical method using periosteum. The left knee of each dog was incised in order to expose the medial femoral condyle, and a circular defect was then made to 5mm in diameter on the articular cartilage of the exposed medial femoral condyle so that chondrocyte implantation using periosteum and the injectable chondrocyte implantation using fibrin glue could both be performed. At week 12 following surgery, the cartilage was observed and compared histologically with normal articular cartilage. Results: The surface of the cartilage newly generated at week 12 was very smooth and even, and it was also seen that the entire area was completely regenerated. Through the histological evaluation, IHC test, and electron microscope pictures, it was verified that collagen type II was normally expressed and that the ultrastructure of the regenerated tissue showed the normal cartilage properties. Conclusion: Gel-type ACI using fibrinfor articular cartilage defects of the knee, appears to be an effective method for the regeneration and growth of cartilage and also has many potential surgical advantages.