Cheong-Sik Kim
Centers for Disease Control and Prevention
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Featured researches published by Cheong-Sik Kim.
Annals of Epidemiology | 2011
Kwang-Pil Ko; Haesook Min; Younjhin Ahn; Seon-Joo Park; Cheong-Sik Kim; Jae Kyung Park; Sung Soo Kim
PURPOSE We studied a cohort of individuals to assess whether intensity of environmental tobacco smoke (ETS) exposure is associated with the incidence of type 2 diabetes. METHODS Study subjects were selected from an ongoing population-based cohort of Korea Genome and Epidemiology Study. Participants of the baseline study 10,038 persons within the age range of 40 to 69 years old. Among 4,442 never smokers without prevalent diabetes, 465 type 2 diabetes cases were identified through biennial active follow-ups for a 6-year period. Cox proportional hazard models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) after adjustment for covariates. RESULTS The risk of type 2 diabetes was higher in subjects exposed to ETS compared with the nonexposure group (HR = 1.41, 95% CI: 1.1-1.70). Daily exposure to ETS at home increased the risk of type 2 diabetes when compared with the risk level of nonexposure (HR = 1.46, 95% CI: 1.16-1.83). Over 4 hours exposure to ETS at home and in the workplace was associated with increased the risk of type 2 diabetes (HR = 1.96, 95% CI: 1.21-3.19). CONCLUSIONS Our study suggests that ETS exposure is a significant risk factor for the development of type 2 diabetes with dose-response relationship.
Journal of Epidemiology | 2012
Kwang-Pil Ko; Dae-Kyu Oh; Haesook Min; Cheong-Sik Kim; Jaekyung Park; Yeonjung Kim; Sung Soo Kim
Background In this prospective cohort study, we estimated the risk of developing more than 1 metabolic risk factor, using different obesity indices. In addition, we investigated the relative usefulness of the obesity indices for predicting development of such risk factors and calculated optimal cutoffs for the obesity indices. Methods The cohort comprised 10 038 representative residents of a small city and a rural county who were recruited in 2001–2002. Follow-up examinations were conducted every 2 years. Among the 3857 participants without metabolic syndrome at baseline, 1102 new cases occurred during the 6-year follow-up. Receiver operating characteristic (ROC) curves for the obesity indices were plotted to compare the usefulness of the obesity indices. Results The numbers of new cases of multiple metabolic risk factors among people in the highest quintiles of body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), and waist-height ratio at the baseline examination were 2 to 3 times those in the lowest quintiles. The area under the ROC curve for WHR was significantly higher than that for BMI. The optimal BMI cutoff was 24 kg/m2 in men and women, and the optimal WC cutoffs were 80 cm and 78 cm in men and women, respectively. Conclusions Both overall obesity and central obesity predicted risk of developing multiple metabolic risk factors, and WHR appeared to be a better discriminator than BMI. To prevent development of metabolic diseases among Koreans, it might be useful to lower the cutoff for abdominal obesity, as defined by WC.
Diabetologia | 2015
Kwang-Pil Ko; Cheong-Sik Kim; Younjhin Ahn; Seon-Joo Park; Yeon-Jeong Kim; Jae Kyung Park; Young-Khi Lim; Keun-Young Yoo; Sung Soo Kim
Aims/hypothesisTo examine the association between soybean products and risk of type 2 diabetes, we measured four isoflavone biological markers—genistein, daidzein, glycitein and equol—in a nested case–control study.MethodsThe study population was composed of 693 cases (316 women and 377 men) and 698 matched controls (317 women and 381 men) within the Korean Genome and Epidemiology Study. The concentrations of isoflavone biomarkers were measured using HPLC-MS/MS on plasma samples that were collected at baseline. A stratified analysis was undertaken to examine the association between plasma isoflavone concentrations and risk of type 2 diabetes according to sex and equol production. Logistic regression models were used to compute ORs and 95% CIs adjusted for confounders.ResultsIn women, compared with the lowest quartile of plasma concentration of genistein, the highest quartile exhibited a significantly decreased risk of diabetes (OR 0.58, 95% CI 0.35, 0.95). When stratified by equol-producing status in women, the OR for diabetes in the highest vs the lowest quartile of genistein concentration was 0.31 (95% CI 0.16, 0.60) in equol producers, but genistein concentration was not associated with risk of diabetes in equol non-producers (p for interaction = 0.013). In men, isoflavone concentrations were not associated with risk of diabetes, regardless of equol-producing status.Conclusions/interpretationHigh plasma concentrations of genistein were associated with a decreased risk of type 2 diabetes in women. This inverse association was prominent in equol-producing participants. These results suggest a beneficial effect of a high intake of soybean products on risk of type 2 diabetes in women.
Annals of Epidemiology | 2009
Lisa Y. Cho; Cheong-Sik Kim; Lian Li; Jae Jeong Yang; Boyoung Park; Aesun Shin; Soung Hoon Chang; Kun-Sei Lee; Hyeongsu Kim; Keun-Young Yoo; Sue K. Park
Self-reported cancer is a valuable epidemiological tool for identifying cases in cohort studies. The cost, time, and resources required, in addition to the efficiency in ascertaining cases, need to be considered when deciding between active and passive follow-up approaches. Because Korean families hold a family-centered approach when making decisions (1), it is not uncommon for patients to be unaware of their cancer diagnosis or status. A total of 20% of physicians and 33% of family members opposed patient notification of his or her disease status (2), and only 35% of Korean-Americans would tell a patient about a terminal prognosis (1). Because of these cultural differences and, thus, inaccuracies in self-reported information that arise, there is a need to examine the appropriateness of the active follow-up
BMC Genetics | 2012
Kyung-Won Hong; Sanghoon Moon; Young-Jin Kim; Yun Kyoung Kim; Dong-Joon Kim; Cheong-Sik Kim; Sung Soo Kim; Bong-Jo Kim
BackgroundRecently, genome-wide association studies identified a pleiotropic gene locus, ABO, as being significantly associated with hematological traits. To confirm the effects of ABO on hematological traits, we examined the link between the ABO locus and hematological traits in Korean population-based cohorts.ResultsSix tagging SNPs for ABO were analyzed with regard to their effects on hematological traits [white blood cell count (WBC), red blood cell count (RBC), platelet (Plat), mean corpuscular volume (MCV), and mean corpuscular haemoglobin concentration (MCHC)]. Linear regression analyses were performed, controlling for recruitment center, sex, and age as covariates. Of the 6 tagging SNPs, 3 (rs2073823, rs8176720, and rs495828) and 3 (rs2073823, rs8176717, and rs687289) were significantly associated with RBC and MCV, respectively (Bonferroni correction p-value criteria < 0.05/6 = 0.008). rs2073823 and a reported SNP (rs8176746), as well as rs495828 and a reported SNP (rs651007), showed perfect linkage disequilibrium status (r2s = 0.99). Of the remaining 3 SNPs (rs8176720, rs8176717 and rs687289), rs8176717 generated an independent signal with moderate p-value (= 0.045) when it was adjusted for by rs2073823 (the most significant SNP). We also identified a copy number variation (CNV) that was tagged by the SNP rs8176717, the minor allele of which correlated with the deletion allele of CNV. Our haplotype analysis indicated that the haplotype that contained the CNV deletion was significantly associated with MCV (β ± se = 0.363 ± 0.118, p =2.09 × 10-3).ConclusionsOur findings confirm that ABO is one of the genetic factors that are associated with hematological traits in the Korean population. This result is notable, because GWASs fail to evaluate the link between a CNV and phenotype traits.
Genes and Nutrition | 2012
Kyung-Won Hong; Kwang-Pil Ko; Younjhin Ahn; Cheong-Sik Kim; Seon-Joo Park; Jae Kyung Park; Sung Soo Kim; Yeonjung Kim
Journal of Preventive Medicine and Public Health | 2001
Hyeongsu Kim; Kun-Sei Lee; Cheong-Sik Kim; Ki-Ock Kim; Soung-Hoon Chang
Clinical Nutrition | 2017
Kwang-Pil Ko; Yohwan Yeo; Ji-Hye Yoon; Cheong-Sik Kim; Shinkan Tokudome; Le Tran Ngoan; Chihaya Koriyama; Young-Khi Lim; Soung-Hoon Chang; Hai-Rim Shin; Daehee Kang; Sue K. Park; Chul Hwan Kang; Keun-Young Yoo
Genes & Genomics | 2013
Kyung-Won Hong; Cheong-Sik Kim; Haesook Min; Seon-Joo Park; Jae Kyung Park; Younjhin Ahn; Sung Soo Kim; Yeonjung Kim
The FASEB Journal | 2008
Younjhin Ahn; Seon-Joo Park; Heejo Koo; Cheong-Sik Kim; Sung-Soo Kim; Mansuk Park