Chi-Cheng Yang

Decompressive craniectomy as the primary surgical intervention for hemorrhagic contusion

The standard surgical treatment of hemorrhagic cerebral contusion is craniotomy with evacuation of the focal lesion. We assessed the safety and feasibility of performing decompressive craniectomy and duraplasty as the primary surgical intervention in this group of patients. Fifty-four consecutive patients with Glasgow Coma Scale (GCS) scores of less than or equal to 8, a frontal or temporal hemorrhagic contusion greater than 20 cm(3) in volume, and a midline shift of at least 5 mm or cisternal compression on computer tomography (CT) scan were studied. Sixteen (29.7%) underwent traditional craniotomy with hematoma evacuation, and 38 (70.4%) underwent craniectomy as the primary surgical treatment. Mortality, reoperation rate, Glasgow Outcome Scale-Extended (GOSE) scores, and length of stay in both the acute care and rehabilitation phase were compared between these two groups. Mortality (13.2% vs. 25.0%) and reoperation rate (7.9% vs. 37.5%) were lower in the craniectomy group, whereas the length of stay in both the acute care setting and the rehabilitation phase were similar between these two groups. The craniectomy group also had better GOSE score (5.55 vs. 3.56) at 6 months. Decompressive craniectomy is safe and effective as the primary surgical intervention for treatment of hemorrhagic contusion. This study also suggests that patient with hemorrhagic contusion can possibly have better outcome after craniectomy than other subgroup of patients with severe traumatic brain injury.

Early clinical characteristics of patients with persistent post-concussion symptoms: A prospective study

Primary objective: To identify the early clinical features of patients with mild traumatic brain injury (mTBI) that are predictive of the presence of persistent post-concussion symptoms (PPCS). Research design: A prospective study was conducted at a level I trauma centre. Methods and procedures: One hundred and eighty mTBI patients participated in this study. The post-concussion symptoms (PCS) were evaluated with a PCS checklist. All patients were examined at 1, 2 and 8 weeks post-injury. The chi-square test was used to evaluate the associations of each PCS and the logistic regression was used to identify potential predictors of mTBI patients who might suffer from PPCS. Main outcomes and results: Less than one-tenth of the mTBI patients examined complained of PPCS at 2 months after head trauma. Patients with PPCS are more likely to suffer from intracranial lesions. Moreover, clinical symptoms at 1 and 2 weeks post-injury, especially physical ones including headache, dizziness and fatigue, were reported significantly more often by patients with PPCS. Conclusions: This study showed that early clinical symptoms and intracranial lesions may be strongly associated with the presence of PPCS. Thus, those specific characteristics may be used as early indicators of long-term difficulties.

Clinical Significance of Posterior Circulation Changes after Revascularization in Patients with Moyamoya Disease

Objective: It has been noted that the posterior circulation serves as an important source of collateral blood supply in moyamoya disease. Since most of the literature has focused on non-operative cases and many symptomatic patients receive surgical revascularization, we evaluated the posterior circulation changes after revascularization and found that progressive posterior cerebral artery (PCA) steno-occlusive changes after revascularization caused cerebral hemodynamic compromise and clinical deterioration in a significant portion of patients. Methods: Twenty-three moyamoya disease patients with ischemic presentation who received revascularization with complete angiography and xenon CT during a minimum of 3 years’ clinical follow-up were enrolled. Revascularization was performed in 38 hemispheres. Pre- and postoperative angiography were reviewed to determine the internal carotid artery (ICA) stage, PCA stage, leptomeningeal collateral (LMC) grade, and Matsushima synangiosis grade. The postoperative regional cerebral blood flow (CBF) and cerebral vascular reserve (CVR) were recorded and correlated with angiographic findings and clinical outcome. Results: Progression of ICA staging was noted in 23 sides (55.2%), and progression of PCA staging was noted in 18 sides (47.4%). Among the 18 cases of PCA stage progression, an associated decrease in LMC grade was noted in 12 sides (66.7%). These changes were associated with decreased regional CBF and CVR, which also explained the recurrent ischemic symptoms in 27.8% of these patients. In contrast, LMC grade increased in 15 (65.2%) sides of patients with ICA progression. Conclusions: Progressive steno-occlusive change in the PCA after revascularization is associated with a reduction in LMC blood flow and cerebral ischemia in moyamoya patients. This phenomenon might cause recurrent ischemic symptoms in 27.8% of patients.

Brain stem cavernous malformations

We retrospectively reviewed the clinical experience of 30 patients with brain stem cavernous malformations (BSCM) treated operatively and non-operatively at our hospital between 1983 and 2005 to elucidate the natural history of BSCM and the factors that affect surgical outcome. Inpatient charts, imaging studies, operative records, and follow-up results were evaluated. The average follow up was 48.5 months. Twenty-two patients (73.3%) received surgical extirpation and of these 86.4% improved or stabilized and 13.6% deteriorated with permanent or severe morbidity. There was no mortality. Size, preoperative status, and surgical timing were factors related to surgical outcome. In the non-operative group, 50% of the patients were the same or better, 25% deteriorated, and 25% died. With appropriate patient selection, resection of BSCM can be achieved with acceptable morbidity compared with the ominous natural history of these lesions.

Longitudinal outcomes of patients with traumatic brain injury: a preliminary study.

Primary objective: To examine the long-term global clinical outcomes of TBI patients from 1 week to 10 years post-injury. Research design: A retrospective study was conducted at a level I trauma centre. Methods and procedures: A total of 327 TBI patients were recruited retrospectively in this longitudinal study and the score of Glasgow Outcome Scale Extended (GOSE) was then documented as an indicator of the clinical outcomes. Main outcomes and results: The results presented that less than one-in-three patients recovered well within 2 weeks after trauma. Around 40% of patients were evaluated as favourable outcomes within 6 months post-injury. Less than 30% of TBI patients could gain favourable outcomes at 3 years post-injury and over half of patients still could not recover well at 6 years. Five patients’ outcomes were continuously followed until 10 years and the results indicated that they started to have good outcomes after 3 years post-injury. Conclusions: This study might be the first one to longitudinally evaluate the outcomes of patients from 1 week to 10 years post-injury and revealed that patients still may have difficulties in social interactions and family relationships until 6 years post-injury, even though they could live and work independently. Hence, professionals should pay attention to the underlying factors causing their difficulties within the long-term recovery process.

Early parenchymal contrast extravasation predicts subsequent hemorrhage progression, Clinical deterioration, and need for surgery in patients with traumatic cerebral contusion

BACKGROUND This study aimed to identify early radiologic signs that are predictive of hemorrhage progression and clinical deterioration in patients with traumatic cerebral contusion. We hypothesized that contrast extravasation (CE) and blood-brain barrier disruption might be associated with hemorrhage progression, brain edema, and clinical deterioration in these patients. METHODS Twenty-two patients with traumatic cerebral contusion (diagnosed on initial noncontrast head computed tomography [CT]) who initially did not require surgical intervention were enrolled in this study. Contrast-enhanced and perfusion CT scans were performed within 6 hours of injury, and follow-up noncontrast CT scans were performed at 24 hours and 72 hours. RESULTS In each noncontrast CT scan, the volumes of the contusion hemorrhage and edema were calculated using computerized planimetric techniques. The initial Glasgow Coma Scale, hemorrhage progression, clinical deterioration, and the need for subsequent surgery were recorded. The early radiologic findings were compared with these parameters and functional outcome at 6 months to identify predictive radiologic signs. CE was present in 9 of 22 patients (41%) and was highly associated with hemorrhage progression (p < 0.05), clinical deterioration (p < 0.01), and need for subsequent surgery (p < 0.01). In addition, patients with CE had a greater volume of edema at 24 hours (p < 0.01) and 72 hours (p < 0.01) than those who did not have CE. However, CE was not found to be associated with poor outcome. CONCLUSIONS Early parenchymal CE is associated with hemorrhage progression, cerebral edema, clinical deterioration, and need for subsequent surgery. These patients should be monitored closely, and early surgery may be needed if deterioration occurs. Further elucidation of the pathophysiology is needed to formulate effective treatment for these high-risk patients.

“Good-old-days” bias: A prospective follow-up study to examine the preinjury supernormal status in patients with mild traumatic brain injury

Primary objective: Postconcussion symptoms (PCS) are common following mild traumatic brain injury (mTBI). A psychological misperception, the “good-old-days” bias, has been indicated as one of the influencing factors on symptom reporting after injury. To date, this response bias has only been examined in a small number of cross-sectional studies. This study thus prospectively evaluated the “good-old-days” bias in patients with mTBI. Research design: A prospective follow-up study. Method and procedures: Fifty-three patients with mTBI were recruited in this study. The PCS was evaluated by the modified Checklist of Postconcussion Symptoms (mCPCS) at 1 month post injury. Twenty-five patients were evaluated again at 3 months after injuries. In addition, 53 healthy participants were also evaluated for the PCS, and 23 of them underwent a second evaluation at 2 months after the first one. Main outcomes and results: Patients with mTBI showed significantly higher PCS reporting at 1 month post injury than healthy participants did, but not at 3 months post injury. Consistent with the “good-old-days” bias, patients remarkably underestimated their preinjury PCS at 1 month post injury. Interestingly, our results further revealed that this response bias diminished more at 3 months than at 1 month after mTBI. Conclusions: This study thus might be the first one to prospectively reveal the progression of the “good-old-days” bias in patients with mTBI.

Acute cerebral ischemia following intraventricular hemorrhage in moyamoya disease: early perfusion computed tomography findings : Case report

The authors present a rare case of an infarction complication 15 days following acute intraventricular bleeding due to moyamoya disease. Before the infarction occurred, perfusion CT imaging disclosed early but reversible ischemic injury on the day of hemorrhage. Dehydration and hypotension are both possibly contributing factors of progressive injury from reversible ischemia due to infarction. Although the patient underwent successful bypass surgery, 1 month after the ictus the neurobehavior evaluation still showed marked executive dysfunction. The authors address that, in hemorrhagic-type moyamoya disease, early perfusion CT scanning is not only a powerful tool to identify the high-risk group of patients who could experience subacute infarction, but also alarms neurosurgeons to eliminate any predisposing factors when it shows reversible ischemic injuries.

Evaluating the impact of hippocampal sparing during whole brain radiotherapy on neurocognitive functions: A preliminary report of a prospective phase II study

Background:Whole brain radiotherapy (WBRT) is the treatment of choice for patients with brain metastases. However, neurocognitive functions (NCFs) decline due to impaired hippocampal neurogenesis might occur thereafter. It is hypothesized that conformal hippocampal avoidance during the course of WBRT (HA-WBRT) might provide meaningful NCF preservation. Our study aims to demonstrate the impact of delivering HA-WBRT on NCF changes in patients receiving WBRT. Methods: Twenty-five patients who were referred for prophylactic cranial irradiation (PCI) or treating oligometastatic brain disease were enrolled in the study. Before the HA-WBRT course, all participants should receive baseline neurocognitive assessment, including memory, executive functions, and psychomotor speed. The primary endpoint was delayed recall, as determined by the change/decline in verbal memory [Wechsler Memory Scale - 3 rd edition (WMS III)- Word List score] from the baseline assessment to 4 months after the start of HA-WBRT. Results: Only three patients belonged to the clinical setting of PCI; the remaining 22 patients had oligometastatic brain disease. Regarding neurocognitive outcomes, no statistically significant differences were found between various NCF scores obtained at baseline and at post-radiotherapy intervals, in immediate verbal memory and non-verbal memory, except for delayed recall memory on Word List (F = 5.727, p = 0.048). Conclusions: Functional preservation by hippocampal sparing during WBRT could largely be achieved in this study, which also suggests that HA-WBRT should be a feasible technique preserving neurocognitive functions while maintaining intracranial control.

Clinical Outcome of Mild Head Injury with Isolated Oculomotor Nerve Palsy

Isolated oculomotor nerve palsy after mild head injury is rare. Only a few case reports have described the clinical presentation of these patients, and clinical and functional outcome have not been discussed in depth. The outcome of 10 patients with mild head injury in whom imaging studies ruled out other possible causes of oculomotor palsy was assessed during follow-up using the Glasgow Outcome Scale-Extended (GOSE). We suggest that limited eye movement is a major factor that negatively affects functional status after mild head injury.