Chien-Fang Peng

Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity

Bioassay-guided fractionation of the root wood of Zanthoxylum wutaiense led to the isolation of 11 new compounds, wutaiensol methyl ether (1), demethoxywutaiensol methyl ether (2), methyl wutaiensate (3), methyl 7-hydroxyanodendroate (4), methyl 7-methoxyanodendroate (5), wutaifuranol (6), 7-methoxywutaifuranol (7), 7-methoxywutaifuranal (8), methyl wutaifuranate (9), methyl 7-methoxybenzofuran-5-carboxylate (10), and wutaipyranol (12), together with another 37 known compounds, of which one, 7-methoxybenzofuran-5-carboxaldehyde (11), was not previously known as a plant constituent. The structures of these isolates were identified by means of spectroscopic analysis. Five of these isolates were found to be antitubercular constituents, namely, methyl 7-methoxyanodendroate (5), 7-methoxywutaifuranal (8), wutaiensal (13), dictamnine (14), and gamma-fagarine (15), which exhibited antitubercular activity against Mycobacterium tuberculosis H37Rv, showing MIC values of 35, 35, 30, 30, and 30 microg/mL, respectively.

Endiandric Acid Analogues from the Roots of Beilschmiedia erythrophloia.

Investigation of the roots of Beilschmiedia erythrophloia has led to the isolation of seven new endiandric acid analogues, erythrophloins A-F (1-6) and beilcyclone A (7), together with 11 known compounds. The structures of 1-7 were determined using spectroscopic techniques. Two constituents, erythrophloin C (3) and suberosol B (8), exhibited antitubercular activity against Mycobacterium tuberculosis H37Rv, showing MIC values of 50 and 28.9 microg/mL, respectively.

seco-Abietane Diterpenoids, a Phenylethanoid Derivative, and Antitubercular Constituents from Callicarpa pilosissima

Six new compounds, including five new seco-abietane diterpenoids, 12-deoxy-seco-hinokiol methyl ester (1), 12-deoxy-11,12-dihydro-seco-hinokiol methyl ester (2), callicarpic acid A (3), 9alpha-hydroxycallicarpic acid A (4), and callicarpic acid B (5), and a new phenylethanoid derivative, 4-hydroxyphenethyl tetradecanoate (6), have been isolated from the leaves and twigs of Callicarpa pilosissima, together with 14 known compounds (7-20). The structures of these new compounds were determined through analyses of physical data. 12-Deoxy-11,12-dihydro-seco-hinokiol methyl ester (2), callicarpic acid B (5), and alpha-tocopherol trimer B (15) exhibit antitubercular activities (MICs <or= 63.6 microM) against Mycobacterium tuberculosis H(37)Rv in vitro.

Antimycobacterial Butanolides from the Root of Lindera akoensis

Three racemic butanolides, majorenolide (1), majorynolide (2), and majoranolide (3), with 18 known compounds, including ten butanolides, i.e., litsenolide A2 (4), litsenolide B2 (5), litsenolide C1 (6), litsenolide C2 (7), hamabiwalactone A (8), hamabiwalactone B (9), litseakolide A (10), litseakolide B (11), isoobtusilactone (12), and obtusilactone (13); one lignan, i.e., (±)‐syringaresinol (14), two flavans, i.e., (+)‐catechin (15), and (−)‐epicatechin (16), one coumarin, i.e., scopoletin (17), and four steroids, i.e., a mixture of β‐sitosterol (18) and stigmasterol (19), and a mixture of β‐sitosteryl‐3‐O‐β‐D‐glucoside (20) and stigmasteryl‐3‐O‐β‐D‐glucoside (21) were isolated from the root of Lindera akoensis. The structures of the isolates were elucidated by in‐depth spectroscopic analysis. Compounds 1–3 were previously assigned a δ‐lactone structure, which was then revised to a γ‐lactone structure, based on 1D‐NMR data. The cigar‐HMBC technique was used to confirm the accuracy of the γ‐lactone structure, and the zero [α]

A New Long‐Chain Alkene and Antituberculosis Constituents from the Leaves of Pourthiaea lucida

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Secondary metabolites from the unripe pulp of Persea americana and their antimycobacterial activities.

value of compounds 1–3 suggested that they were considerably racemized. Nine butanolides 1–3, 4–8, and 10 showed antimycobacterial activities against M. tuberculosis H37Rv, with MIC values of 15–50 μg/ml.

Secondary metabolites from the roots of Litsea hypophaea and their antitubercular activity.

A new long‐chain alkene, dotriacont‐1‐ene (1), was isolated from the leaves of Pourthiaea lucida, together with twelve known compounds. The structure of this new compound was determined by NMR and mass‐spectrometric analyses. Among the isolated compounds, α‐tocospiro A (2), α‐tocopheryl quinone (4), and (E)‐phytol (5) exhibited antituberculosis activities (MICs ≤30 μg/ml) against Mycobacterium tuberculosis H37Rv in vitro.

A new dihydroagarofuranoid sesquiterpene and antituberculosis constituents from the root of Microtropis japonica.

The fruits of Persea americana (Avocado) are nowadays used as healthy fruits in the world. Bioassay-guided fractionation of the active ethyl acetate soluble fraction has led to the isolation of five new fatty alcohol derivatives, avocadenols A-D (1-4) and avocadoin (5) from the unripe pulp of P. americana, along with 12 known compounds (6-17). These structures were elucidated by spectroscopic analysis. Among the isolates, avocadenol A (1), avocadenol B (2), (2R,4R)-1,2,4-trihydroxynonadecane (6), and (2R,4R)-1,2,4-trihydroxyheptadec-16-ene (7) showed antimycobacterial activity against Mycobacterium tuberculosis H(37)R(V)in vitro, with MIC values of 24.0, 33.8, 24.9, and 35.7 μg/ml, respectively.

New flavanones from the leaves of Cryptocarya chinensis and their antituberculosis activity.

Bioassay-guided fractionation of the roots of Litsea hypophaea led to the isolation of seven new butanolides, namely, litseakolides H-N (1-7), all with the 3R,4S configuration, as well as three new biarylpropanoids, hypophaone (8), hypophaol (9), and hypophane (10), and 15 known compounds. The structures of 1-10 were determined by means of spectroscopic analysis. Litseakolide L (5) and N-trans-feruloylmethoxytyramine (11) showed antitubercular activity against Mycobacterium tuberculosis strain H(37)Rv, with MIC values of 25 and 1.6 microg/mL, respectively.

Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities.

A new dihydroagarofuran‐based sesquiterpene, 15‐acetoxyorbiculin A (1), was isolated from the root of Microtropis japonica, together with 13 known compounds. Their structures were determined through in‐depth spectroscopic and mass‐spectrometric analyses. Among the isolated compounds, celahin C (6) and salasol A (7) exhibited potent in vitro antituberculosis activity, both with an MIC value of 15.0 μg/ml against Mycobacterium tuberculosis H37Rv.