Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Chika Kikuchi.
Bioorganic & Medicinal Chemistry Letters | 2002
Chika Kikuchi; Toyokazu Hiranuma; Masao Koyama
The synthesis and the affinity for the 5-HT(7) receptor and other receptors of a novel series of fused-ring tetrahydropyridine derivatives are described. Some of the compounds showed high affinity for the 5-HT(7) receptor. Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles and are potent ligands for the 5-HT(7) receptor, with high selectivity over the 5-HT(2) receptor and other receptors. These compounds should be useful tools for clarifying the biological role of the 5-HT(7) receptor.
Bioorganic & Medicinal Chemistry Letters | 2003
Chika Kikuchi; Hisashi Suzuki; Toyokazu Hiranuma; Masao Koyama
Chemical modifications of compound 1 (DR4004), a potent, selective antagonist of the 5-HT(7) receptor, were conducted with the aim of improving its metabolic stability. Halogenation of putative sites of oxidative metabolism afforded compounds 7-10, which retained high affinity and selectivity for the 5-HT(7) receptor, and showed increased in vitro metabolic stability. Compound 10 (DR4485) showed oral bioavailability, and should be a useful tool for evaluating the therapeutic potential of 5-HT(7) antagonists.
Journal of Medicinal Chemistry | 1999
Chika Kikuchi; Hiroshi Nagaso; Toyokazu Hiranuma; Masao Koyama
Journal of Medicinal Chemistry | 2002
Chika Kikuchi; Takashi Ando; Takashi Watanabe; Hiroshi Nagaso; Masayo Okuno; Toyokazu Hiranuma; Masao Koyama
Archive | 2000
Kenichi Fushihara; Chika Kikuchi; Tetsuya Matsushima; Kenichi Kanemoto; Eriko Satoh; Takehiro Yamamoto; Kokichi Suzuki
Archive | 1999
Masao Koyama; Osamu Ushiroda; Chika Kikuchi; Takashi Ando; Eriko Morita; Masayo Okuno; Toyokazu Hiranuma
Archive | 2002
Kenichi Fushihara; Chika Kikuchi; Tetsuya Matsushima; Kenichi Kanemoto; Eriko Satoh; Takehiro Yamamoto; Kokichi Suzuki
Archive | 2000
Kenichi Fushihara; Kenichi Kanemoto; Chika Kikuchi; Tetsuya Matsushima; Eriko Satoh; Kokichi Suzuki; Takehiro Meiji Seika Kaisha Ltd. Yamamoto
Archive | 2001
Masao Koyama; Osamu Ushiroda; Chika Kikuchi
Archive | 2000
Kenichi Fushihara; Kenichi Kanemoto; Chika Kikuchi; Tetsuya Matsushima; Eriko Satoh; Kokichi Suzuki; Takehiro Meiji Seika Kaisha Ltd. Yamamoto
