Chikako Inaba
Dokkyo Medical University
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Publication
Featured researches published by Chikako Inaba.
Journal of Hypertension | 2008
Shogo Koshikawa; Toshio Nishikimi; Chikako Inaba; Kazumi Akimoto; Hiroaki Matsuoka
Background In this study, we tested the hypothesis that long-term Rho-kinase inhibition would reverse nitro-L-arginine methyl ester-exacerbated nephrosclerosis in spontaneously hypertensive rats and attempted to elucidate the mechanism involved. Methods Five groups (each n = 8) were studied: untreated spontaneously hypertensive rats; nitro-L-arginine methyl ester (50 mg/l in drinking water, for 3 weeks)-treated spontaneously hypertensive rats; nitro-L-arginine methyl ester with fasudil (10 mg/kg/day)-treated spontaneously hypertensive rats; nitro-L-arginine methyl ester for 3 weeks followed by fasudil for 3 weeks-treated spontaneously hypertensive rats (same doses), and nitro-L-arginine methyl ester for 3 weeks followed by untreated for 3 weeks. We examined renal function, blood pressure, histological features, oxidative stress markers, and mRNA expression in the renal cortex. Results Nitro-L-arginine methyl ester-treated spontaneously hypertensive rats had higher blood pressure, proteinuria, and serum creatinine and lower creatinine clearance, urinary NO3/NO2 ratio, and urinary cGMP excretion compared with control spontaneously hypertensive rats (all Ps < 0.05). Nitro-L-arginine methyl ester-treated spontaneously hypertensive rats also had increased free radical metabolites and abnormal morphological findings with increased nicotinamide adenine dinucleotide phosphate oxidase activity, phosphorylation of myosin phosphatase targeting subunit-1, and mRNA expression of RhoA, RhoB, RhoC, collagen I and III, transforming growth factor-β, nicotinamide adenine dinucleotide phosphate subunit, endothelial nitric oxide synthase, plasminogen activator inhibitor, and intercellular adhesion molecule-1 in the renal cortex compared with control spontaneously hypertensive rats. Long-term co-treatment with fasudil slightly improved these indices, but most of them were not statistically significant. Late fasudil treatment significantly improved kidney function, morphological changes, and alterations of mRNA expression in the renal cortex, although late untreated controls did not show any improvement. Conclusion These results suggest that Rho-kinase inhibition partly reverses hypertensive glomerulosclerosis. The renoprotective effect of the Rho-kinase inhibitor may have multiple mechanisms including inhibition of extracellular matrix production, oxidative stress, adhesion molecule production, and antifibrinolysis.
Journal of Hypertension | 2007
Toshio Nishikimi; Shogo Koshikawa; Yayoi Ishikawa; Kazumi Akimoto; Chikako Inaba; Kimihiko Ishimura; Hidehiko Ono; Hiroaki Matsuoka
Japanese Circulation Journal-english Edition | 2009
Toshio Nishikimi; Tsuyoshi Karasawa; Chikako Inaba; Kimihiko Ishimura; Kazuyoshi Tadokoro; Shogo Koshikawa; Fumiki Yoshihara; Noritoshi Nagaya; Hideaki Sakio; Kenji Kangawa; Hiroaki Matsuoka
Circulation | 2009
Toshio Nishikimi; Tsuyoshi Karasawa; Chikako Inaba; Kimihiko Ishimura; Kazuyoshi Tadokoro; Shogo Koshikawa; Fumiki Yoshihara; Noritoshi Nagaya; Hideaki Sakio; Kenji Kangawa; Hiroaki Matsuoka
Journal of Cardiac Failure | 2008
Kimihiko Ishimura; Toshio Nishikimi; Chikako Inaba; Kazuyoshi Tadokoro; Shogo Koshikawa; Hiroaki Matsuoka; Masashi Ikeda; Masako Matsubara; Naoto Minamino
Journal of Cardiac Failure | 2007
Chikako Inaba; Toshio Nishikimi; Tsuyoshi Karasawa; Yayoi Ishikawa; Shogo Koshikawa; Hideaki Sakio; Hiroaki Matsuoka; Fumiki Yoshihara; Kenji Kangawa
Japanese Circulation Journal-english Edition | 2007
Toshio Nishikimi; Yayoi Ishikawa; Chikako Inaba; Shogo Koshikawa; Kimihiko Ihsimura; Fumiki Yoshihara; Kenji Kangawa; Hiroaki Matsuoka
Japanese Circulation Journal-english Edition | 2007
Toshio Nishikimi; Kimihiko Ishimura; Shogo Koshikawa; Chikako Inaba; Yayoi Ishikawa; Hiroaki Matsuoka; Takeshi Karasawa; Hideaki Sakio; Fumiki Yoshihara; Noritoshi Nagaya; Kenji Kangawa
Japanese Circulation Journal-english Edition | 2007
Yayoi Ishikawa; Toshio Nishikimi; Chikako Inaba; Shogo Koshikawa; Kimihiko Ishimura; Kazuyoshi Tadokoro; Hiroaki Matsuoka
Japanese Circulation Journal-english Edition | 2007
Shogo Koshikawa; Toshio Nishikimi; Kimihiko Ishimura; Chikako Inaba; Yayoi Ishikawa; Hiroaki Matsuoka