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Chikako Murasaki

Hoffmann-La Roche

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Publication

Featured researches published by Chikako Murasaki.

Bioorganic & Medicinal Chemistry Letters | 2002

Synthesis of novel water soluble benzylazolium prodrugs of lipophilic azole antifungals

Jun Ohwada; Chikako Murasaki; Toshikazu Yamazaki; Shigeyasu Ichihara; Isao Umeda; Nobuo Shimma

Water soluble N-benzyltriazolium or N-benzylimidazolium salt type prodrugs of several highly lipophilic triazole or imidazole antifungals have been synthesized. They were designed to undergo an enzymatic activation followed by a self-cleavage to release a parent drug. The prodrugs such as 16 had enough chemical stability and water solubility for parenteral use and were rapidly and quantitatively converted to the active substance in human plasma.

Bioorganic & Medicinal Chemistry | 2000

The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine

Nobuo Shimma; Isao Umeda; Motohiro Arasaki; Chikako Murasaki; Kazunao Masubuchi; Yasunori Kohchi; Masanori Miwa; Masako Ura; Noriaki Sawada; Hitoshi Tahara; Isamu Kuruma; Ikuo Horii; Hideo Ishitsuka

Archive | 1993

N4-(substituted-oxycarbonyl)-5'-deoxy-5-fluorocytidine compounds, compositions and methods of using same

Motohiro Arasaki; Hideo Ishitsuka; Isami Kuruma; Masanori Miwa; Chikako Murasaki; Nobuo Shimma; Isao Umeda

Archive | 1993

N-Oxycarbonyl substituted 5'-deoxy-5-fluorocytidines

Motohiro Arasaki; Hideo Ishitsuka; Isami Kuruma; Masanori Miwa; Chikako Murasaki; Nobuo Shimma; Isao Imperial Higashihakuraku Umeda

Archive | 1997

N-Benzylimidazolium and N-benzyltriazolium derivatives, their preparation and their use as antifungal and antimycotic agents

Shigeyasu Ichihara; Chikako Murasaki; Noriko Ohga; Jun Ohwada; Daisuke Sawada; Nobuo Shimma; Michio Shirai; Isao Imp.Higashihakuraku Gar.House Rm B Umeda

Archive | 1997

N-benzylazolium derivatives

Shigeyasu Ichihara; Chikako Murasaki; Noriko Ohga; Jun Ohwada; Daisuke Sawada; Nobuo Shimma; Michio Shirai; Isao Umeda

Archive | 2004

DERIVES DE N-BENZYLAZOLIUM

Shigeyasu Ichihara; Noriko Ohga; Jun Ohwada; Nobuo Shimma; Michio Shirai; Chikako Murasaki; Daisuke Sawada; Isao Umeda

Archive | 1999

N-HYDROXYCARBONYL-SUBSTITUTED 5'-DEOXY-5-FLUOROCYTIDINES, PHARMACEUTICAL PREPARATION

Motokhiro Arasaki; Khideo Ishitsuka; Isami Kuruma; Masanori Miva; Chikako Murasaki; Nobuo Shimma; Isao Umeda

Archive | 1998

DERIVADOS DE N-BENCILAZOLIO

Shigeyasu Ichihara; Chikako Murasaki; Noriko Ohga; Jun Ohwada; Daisuke Sawada; Nobuo Shimma; Michio Shirai; Isao Umeda

Archive | 1998

N4-(asendatud-oksükarbonüül)-5'-desoksü-5-fluorotsütidiinid, nende saamise meetod ja neid sisaldavad ravimpreparaadid

Motohiro Arasaki; Hideo Ishitsuka; Isami Kuruma; Masanori Miwa; Chikako Murasaki; Nobuo Shimma; Isao Umeda

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Hideo Ishitsuka

Hoffmann-La Roche

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Isami Kuruma

Hoffmann-La Roche

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Motohiro Arasaki

Hoffmann-La Roche

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Nobuo Shimma

Chugai Pharmaceutical Co.

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Isao Umeda

Ebara Corporation

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Masanori Miwa

Chugai Pharmaceutical Co.

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Jun Ohwada

Hoffmann-La Roche

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Nobuo Shimma

Chugai Pharmaceutical Co.

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Shigeyasu Ichihara

Hoffmann-La Roche

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Daisuke Sawada

Hoffmann-La Roche

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