Chitoshi Hatanaka
Takeda Pharmaceutical Company
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Publication
Featured researches published by Chitoshi Hatanaka.
Biochemical and Biophysical Research Communications | 1974
Chitoshi Hatanaka; Mikihiko Obayashi; Osamu Nishimura; Noriaki Toukai; Masahiko Fujino
An improved synthesis of thyrotropin releasing hormone (TRH), pGlu-His-Pro-NH2, is reported. Z-pGlu-ONB (N-hydroxy-5-norbornene-2,3-dicarboximide ester) was reacted with H-His-OH to yield a crystalline Z-pGlu-His-OH which was coupled with H-Pro-NH2 by the HONBDCC method to give Z-pGlu-His-Pro-NH2 as a fine crystal. Hydrogenation of this protected tripeptide yielded pure TRH nearly quantitatively. The optical purity of TRH thus obtained was confirmed by the method L- and D- amino acid oxidase digestion. The crystallization of TRH was achieved as a tartrate, and the properties of the crystalline TRH-tartrate are described.
Chemical & Pharmaceutical Bulletin | 1991
Yu Momose; Kanji Meguro; Hitoshi Ikeda; Chitoshi Hatanaka; Satoru Oi; Takashi Sohda
Archive | 1987
Kanji Meguro; Takeshi Fujita; Chitoshi Hatanaka; Satoru Ooi
Chemical & Pharmaceutical Bulletin | 1980
Naohisa Fukuda; Osamu Nishimura; Mutsushi Shikata; Chitoshi Hatanaka; Masaomi Miyamoto; Yoshiaki Saji; Ryo Nakayama; Masahiko Fujino; Yuji Nagawa
Chemical & Pharmaceutical Bulletin | 1968
Masahiko Fujino; Chitoshi Hatanaka
Archive | 1997
Chitoshi Hatanaka; Yasuaki Abe; Mitsuhisa Yamano
Chemical & Pharmaceutical Bulletin | 1971
Masahiko Fujino; Chitoshi Hatanaka; Osamu Nishimura
Chemical & Pharmaceutical Bulletin | 1967
Masahiko Fujino; Chitoshi Hatanaka
Chemical & Pharmaceutical Bulletin | 1975
Osamu Nishimura; Chitoshi Hatanaka; Masahiko Fujino
Archive | 1997
Kanji Meguro; Takeshi Fujita; Chitoshi Hatanaka; Satoru Ooi
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