Chizuko Toyoda

Cardiovascular dysautonomia in de novo Parkinson’s disease without orthostatic hypotension

Background:  Clinical symptoms of Parkinson’s disease (PD) include not only motor distress, but also autonomic dysfunction.

Body weight and dysautonomia in early Parkinson's disease

Patients with Parkinsons disease (PD) begin to lose weight several years before diagnosis, which suggests weight variation is associated with some factor(s) that precede the onset of motor symptoms. This study aimed to investigate the association of autonomic nervous system with body weight in patients with PD.

Pearls & Oy-sters: Trigeminal neuropathy associated with herpes labialis

A previously healthy 41-year-old woman with recurrent herpes labialis since her 20s noticed a herpes labialis lesion on the left side of the lower lip. After 2 days, she experienced the acute onset of tingling and a swollen sensation of the left side of the face, beginning at the V3 division of the trigeminal nerve and progressing to involve the V1 and V2 divisions over the course of 2 days. A dermatologist diagnosed herpes labialis and prescribed acyclovir 1,000 mg in 2 divided doses for 5 days. However, the symptoms did not improve after the lesion disappeared. The left side of the tongue perceived a bitter taste 8 days after the onset of symptoms. Examinations …

The development of chronic inflammatory demyelinating polyneuropathy during adalimumab treatment in a patient with psoriasis vulgaris

We report a case of psoriasis vulgaris in which chronic inflammatory demyelinating polyneuropathy (CIDP) developed during adalimumab treatment. A 42-year-old Japanese man with a history of juvenile-onset psoriasis, who had been treated with topical vitamin D analogues and corticosteroids for a long time, as well as oral cyclosporine for the last one and a half years, was administered adalimumab with a regular dose (initial dose of 80 mg, followed by 40 mg, twice a week). Seven months later, due [...]