Choong Meng Chan
Singapore General Hospital
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Featured researches published by Choong Meng Chan.
PLOS ONE | 2015
Cynthia C. Lim; Boon Wee Teo; E. Shyong Tai; Su Chi Lim; Choong Meng Chan; Sunil Sethi; Tien Yin Wong; Charumathi Sabanayagam
Background Adiponectin and leptin, two of the key cytokines secreted by adipocytes, have been shown to be associated with cardiovascular disease. However, the association of these adipocytokines with chronic kidney disease (CKD) is not clear. We examined the association of serum adiponectin, leptin levels and leptin to adiponectin ratio (LAR) with CKD in a population-based sample of Asian adults. Methods We conducted a case-control study (450 CKD cases and 920 controls matched for age, sex and ethnicity) involving Chinese and Indian adults aged 40–80 years who participated in the Singapore Epidemiology of Eye Diseases Study (2007–2011). CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73m2 from serum creatinine. Serum adiponectin and leptin levels were measured using commercially available ELISA. Odds ratio of CKD associated with elevated adiponectin and leptin levels were estimated using logistic regression models adjusted for age, gender, ethnicity, education, smoking, body mass index, diabetes, blood pressure, total and HDL cholesterol. Results CKD cases had higher levels of leptin (mean [SD] 9.7 [11.5] vs.16.9 [20.2] ng/mL, p<0.0001) and adiponectin (10.4 [7.4] vs. 9.2 [4.2], p = 0.001) compared to controls. In multi-variable models, compared to those in the lowest quartile, the OR (95% confidence interval) of CKD among those in the highest quartile were: 6.46 (3.84, 10.88), 1.94 (1.32–2.85) and 2.88 (1.78–4.64) for leptin, adiponectin and LAR. Similar associations were also observed when adiponectin and leptin were analyzed as continuous variables. This positive association of serum adiponectin, leptin and LAR with CKD was consistently present in subgroups of gender, ethnicity, diabetes, hypertension and overweight status (all P-interaction >0.1). Conclusions Higher levels of serum adiponectin, leptin and LAR were positively associated with CKD independent of traditional risk factors in this Asian population.
Nephrology | 2017
Cynthia C. Lim; Pei Yun Liu; Hui Zhuan Tan; Peishan Lee; Yok Mooi Chin; Irene Yj Mok; Choong Meng Chan; Jason Cj Choo
Lupus nephritis (LN) is associated with significant morbidity and mortality and hence usually treated aggressively with immunosuppressants. This predisposes LN patients to increased infections, yet few studies have evaluated LN patients for infective complications. We aimed to describe the epidemiology and identify risk factors for infections requiring hospitalization among patients with biopsy‐proven LN.
PLOS ONE | 2016
Zhen Li Yu; Vanessa Yin Woan Lee; Augustine Wee Cheng Kang; Sally Wai-Chi Chan; Marjorie Foo; Choong Meng Chan; Konstadina Griva
With increasing emphasis on expanding home-based dialysis, there is a need to understand adherence outcomes. This study set out to examine the prevalence and predictors of nonadherence among patients undergoing peritoneal dialysis. A cross sectional sample of 201 peritoneal dialysis patients recruited between 2010–2011 from Singapore General Hospital completed measures of quality of life, medication beliefs, self-efficacy and emotional distress. Nonadherence rates were high; 18% for dialysis, 46% for medication and 78% for diet. Intentional nonadherence was more common for dialysis (p = .03), whereas unintentional nonadherence was more common for medication (p = .002). Multivariate models indicated significant associations for higher education (intermediate vs low OR = 3.18, high vs low OR = 4.70), lower environment quality of life (OR = 0.79), dialysis self-efficacy (OR = 0.80) with dialysis nonadherence; higher education (OR = 2.22), self-care peritoneal dialysis (OR = 3.10), perceived necessity vs concerns over medication (OR = 0.90), self-efficacy (OR = 0.76) with nonadherence to medication. The odds for nonadherence to diet were higher among patients who were younger (OR = 0.96), of Chinese ethnicity (OR = 2.99) and those reporting better physical health (OR = 1.30) and lower self-efficacy (OR = 0.49). Nonadherence is common in peritoneal dialysis. Self-efficacy and beliefs about medication are promising targets for interventions designed to improve adherence.
Nephrology | 2018
Edlyn Gui Fang Tan; Irene Teo; Eric A. Finkelstein; Choong Meng Chan
In Singapore, most elderly end‐stage renal disease (ESRD) patients choose dialysis over palliative management. However, dialysis may not be the optimal treatment option given only moderate survival benefits and high costs and treatment burden compared to non‐dialysis management. Elderly patients may therefore come to regret this decision. This study investigated: (i) extent of patients’ decision regret after starting dialysis, and (ii) potentially modifiable predictors of regret: satisfaction with chronic kidney disease education, decisional conflict, and decision‐making involvement.
International Urology and Nephrology | 2016
Konstadina Griva; Augustine Wee Cheng Kang; Zhen Li Yu; Vanessa Yin Woan Lee; Sotirios G. Zarogiannis; Choong Meng Chan; Marjorie Foo
Background Emotional distress is common in dialysis patients, but its role on clinical outcomes for patients on peritoneal dialysis (PD) is uncertain.
Annals Academy of Medicine Singapore | 2005
Choong Meng Chan
Annals Academy of Medicine Singapore | 2009
Keng Thye Woo; Yeow Kok Lau; Kok-Seng Wong; Yi Zhao; Choong Meng Chan
Annals Academy of Medicine Singapore | 2010
Keng Thye Woo; Yeow Kok Lau; Yi Zhao; Kim Yoong Puong; Hwee Boon Tan; Stephanie Fook-Chong; Kok-Seng Wong; Choong Meng Chan
Nephrology Dialysis Transplantation | 2018
Hui Zhuan Tan; Jia Liang Kwek; Stephanie Fook-Chong; Choong Meng Chan; Jason Chon Jun Choo
Kidney International | 2018
Cynthia C. Lim; Jason Chon Jun Choo; Choong Meng Chan; Keng Thye Woo