Chrisostomos Maltezos

Surgical Treatment of Carotid Body Tumours

OBJECTIVE To evaluate our results of the treatment of patients with carotid body tumours. DESIGN Retrospective study. SETTING University hospital, Greece. SUBJECTS 17 patients operated on for a carotid body tumour during the past 20 years. MAIN OUTCOME MEASURES Hospital mortality and morbidity, long-term outcome. RESULTS 3 patients had temporary cranial nerve lesions postoperatively, all of which resolved within three months. One patient developed a severe stroke and died seven days postoperatively. During follow-up that ranged from 7 months to 20 years, two patients died of unrelated causes. 5 patients were lost to follow up, and the remaining 10 were doing well with no signs of recurrence at the time of writing. CONCLUSION Excision of a carotid body tumour is recommended at the time of initial diagnosis in good-risk patients to avoid the difficulty of subsequent excision of an enlarging and highly vascular tumour with possible encasement of the carotid artery.

THE VALIDITY OF CURRENT VASCULAR IMAGING METHODS IN THE EVALUATION OF AORTIC ANASTOMOTIC ANEURYSMS DEVELOPING AFTER ABDOMINAL AORTIC ANEURYSM REPAIR

The aim of this cross-sectional study was to evaluate the validity of current imaging methods for diagnosing anastomotic false aneurysms (AFA) of the aorta. One hundred four patients who had undergone elective abdominal aortic aneurysm repair between January 1, 1985, and May 31, 1991, were studied. All of them were investigated for potential development of an aortic anastomotic aneurysm by B-mode ultrasonography, CT scanning, digital subtraction arteriography, and MRI. These findings were compared with results of color-coded Doppler imaging, which is considered the “gold standard,” and were subsequently classified as true positive or true negative. The accuracy of color Doppler ultrasound was independently evaluated by clinical examination of the patients, which was carried out for a mean period of 77.5 months during follow-up. On the basis of the data obtained and observations made during follow-up (mean 36.4 months), the sensitivity and specificity of the preceding imaging methods were estimated. Aortic anastomotic aneurysms were detected in two patients (1.9%). The sensitivity of all methods was 100% and specificity was as follows: 74.2% for ultrasound, 59.8% for nonenhanced CT scans, 85.4% for enhanced CT scans, and 99% for digital subtraction arteriograms. Color Doppler and MRI were 100% specific for ruling out aortic anastomotic aneurysms. In a comparison of the accuracy, estimated cost, safety, and the availability of each method, color Doppler appeared to be the diagnostic method of choice for identifying aortic anastomotic aneurysms after abdominal aortic aneurysm repair.

Case report of a patient with iliac occlusive disease due to pseudoxantoma elasticum and review of the bibliography.

BACKGROUND Pseudoxanthoma elasticum (PXE) is a rare genetic disorder characterized by progressive calcification and fragmentation of elastic fibers in the skin, the retina, and the cardiovascular system, and is also termed as elastorrhexia. The purpose of this case presentation is to report the case of a PXE patient with an atypical localization of atherosclerotic lesion (iliac arteries) and that this rare disease should always be included in the differential diagnosis of patients with premature atheromatosis. METHODS AND RESULTS A 58-year-old patient, suffering from PXE, came to our clinic to seek advice for his severe lower limb claudication. The image of the magnetic resonance angiography of his aorta, iliac arteries, and lower limb arteries demonstrated total occlusion of the left common iliac artery and preocclusive stenosis of the orifice on the right common iliac artery. The patient was treated successfully by angioplasty with kissing stent placement at the iliac arteries, and 6 months later, he is symptom-free, with ankle-brachial indexes of 1.0 and 1.05 on the left and right legs, respectively. CONCLUSION This case report presentation has a primary goal to show that the disease may cause atypical localizations of atherosclerosis (iliac arteries) and a secondary goal to demonstrate that endovascular treatment in these patients may be a safe and viable option. It is also a good opportunity for a brief review of the bibliography.

False Arterial Aneurysm due to Long Bone Exostosis: Presentation of Two Cases and Update on Proper Management

Osteochondromas are the most common benign bone tumors. Vascular complications are unusual, with false arterial aneurysms being the majority among them. Although there are several reports of false aneurysms because of an exostosis in the femoro-popliteal region, cases presenting with a false aneurysm of the brachial artery are quite rare. Many suggestions have been made regarding prevention, diagnosis, and treatment of these false aneurysms, although there are no official guidelines. Therefore, this report aims to present 2 unusual cases of patients with a false aneurysm in the femoral and brachial artery, respectively, because of an exostosis. Literature data are discussed and useful conclusions regarding optimal management are made.

Measurement of cystatin C in human urine by particle-enhanced turbidimetric immunoassay on an automated biochemistry analyzer.

BACKGROUND Cystatin C (CysC), is produced by all the nucleated cells of the human body, is freely filtered by the kidney glomerulus and reabsorbed by the tubules. It is widely accepted that no tubular secretion of CysC occurs. Raised urinary levels are believed to indicate tubular damage. METHODS We report here the validation of a quantitative assay to measure urinary cystatin C (uCysC) using a commercial CysC kit based on a latex particle-enhanced turbidimetric immunoassay (PETIA), on an automated biochemistry analyzer. The clinical relevance of this assay was tested on several kidney disease patients and a reference range was determined using healthy controls. RESULTS The assay is precise (total CV<4%), and sensitive (limit of quantification=0.06 mg/dL, and limit of detection=0.02 mg/L). Calibration is stable for at least 30 days. The assay showed very good linearity over the studied interval (0.02 to 2.25mg/L). Recovery ranged from 101.62 to 106.49%. The analyte is stable, at 4°C for at least 2 days, and at 20°C for 48 h. The upper reference value was 0.12 mg/L Median uCysC concentration in 30 acute kidney injury patients (1.47 mg/L, interquartile range=0.27-3.87 mg/L) and was significantly higher than that in 25 patients with normal kidney function (0.05, 0.03-0.12; p<0.0001), 30 patients with chronic kidney disease (0.13, 0.05-0.77; p<0.0001) and 15 patients with pre-renal azotemia (0.15, 0.08-0.31; p<0.0001). CONCLUSION Our data indicate that uCysC can be processed on automated biochemistry analyzers and its measurement could easily be added to a standard panel to screen kidney diseases.

Bilateral Type IIIa Endoleak and Disconnection of Both Limbs after Evar with an Endurant II Endograft

A 75-year-old patient with severe comorbidities was treated with an Endurant® (Medtronic, USA) II endograft due to a ruptured abdominal aortic aneurysm (AAA). After four years of unremarkable follow-up, bilateral limb separation was detected. The patient underwent endovascular bridging without any complication. Although rarely detected in newer grafts, late bilateral type IIIa endoleaks can present and should be promptly repaired. Complex or ruptured AAAs treated with off-label use of endografts should be under closer surveillance using imaging tools for potential endoleaks or aneurysm sac growth.

Bioabsorbable stenting in peripheral artery disease

Arterial stenting has been broadly utilized for the management of peripheral arterial occlusive disease. The evolution of stent materials has led to the introduction of newer bioabsorbable scaffolds that have been extensively evaluated in the treatment of coronary artery disease. However, the utilization of bioabsorbable stents in the lower extremities remains challenging and has not been evaluated in the same degree. There are not many trials focusing on major outcomes of treatment with bioabsorbable stents or comparing them with other therapeutic choices such as surgery or angioplasty only. The aim of this review is to report current status on bioabsorbable stenting in peripheral artery disease treatment as well as to present the results of all major relevant trials. Moreover, future expectations and challenges with this type of stents are discussed as well.

Thrombolysis in peripheral artery disease

Peripheral artery disease (PAD) has been associated with severe morbidity and mortality worldwide, affecting the quality of life for millions of patients. Acute thrombosis has been identified as a major complication of PAD, with proper management including both open as well as endovascular techniques. Thrombolysis has emerged as a reasonable option in the last decades to treat such patients although data produced by randomized trials have been limited. This review aims to present major aspects of thrombolysis in PAD regarding its indications and contraindications, technique tips as well as to review literature data in order to produce useful conclusions for everyday clinical practice.

Multidisciplinary Management of Carotid Body Tumors in a Tertiary Urban Institution

Objective. Aim of this study is to present the experience of our institution in carotid body tumors (CBTs) treatment. Methods. All cases treated in a Vascular Surgery Department within 2.5 years (03/2013–09/2015) were retrospectively evaluated. Demographics, diagnostic, and treatment strategy were recorded. All patients with known CBT underwent ultrasound and magnetic resonance imaging preoperatively. All cases were classified according to the Shamblin type and evaluated by a radiologist, otolaryngologist, and anesthesiologist before and after surgery. Major outcomes included mortality, stroke, cranial nerve injury, and recurrence. Results. Overall, nine patients (mean age: 59.5 ± 16.3 years) with a total of ten CBTs were treated. There was no gender prevalence and most of the cases (55%) were asymptomatic. There were no functional or familial cases. There was only one bilateral case treated in a staged manner. No preoperative embolization of CBTs was performed. Mortality and stroke rates were null. No severe complication was observed in the early and late setting. No malignancy was recorded. Mean follow-up was 15.6 ± 7.8 months. Conclusions. Multidisciplinary management of patients with CBTs is imperative for optimal results, especially in type III tumors, bilateral or functional cases. After careful treatment planning and intraoperative manipulations, complications could be avoided even without preoperative embolization.

Acute type B aortic dissection: update on proper management

Article history: Received 8 January 2015 Received in revised form 11 January 2015 Accepted 14 January 2015 Available online