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Dive into the research topics where Christian Bisang is active.

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Featured researches published by Christian Bisang.


Chemical Communications | 1996

A template for the solid-phase synthesis of conformationally restricted protein loop mimetics

Fabienne Emery; Christian Bisang; Michel Favre; Luyong Jiang; John A. Robinson

A trifunctional template 1 is synthesized from trans-4-hydroxy-L-proline and L-aspartic acid, immobilized on a solid-support, and used for the solid-phase synthesis of a cyclic conformationally restrained hexapeptide loop mimetic containing the motif Asn-Pro-Asn-Ala (NPNA); this is shown by NMR to populate a stable β-turn conformation in aqueous solution.


Bioorganic & Medicinal Chemistry | 2017

Advances in macrocyclic peptide-based antibiotics

Anatol Luther; Christian Bisang; Daniel Obrecht

Macrocyclic peptide-based natural products have provided powerful new antibiotic drugs, drug candidates, and scaffolds for medicinal chemists as a source of inspiration to design novel antibiotics. While most of those natural products are active mainly against Gram-positive pathogens, novel macrocyclic peptide-based compounds have recently been described, which exhibit potent and specific activity against some of the most problematic Gram-negative ESKAPE pathogens. This mini-review gives an up-date on recent developments.


Journal of the American Chemical Society | 1995

Stabilization of Type-I .beta.-Turn Conformations in Peptides Containing the NPNA-Repeat Motif of the Plasmodium falciparum Circumsporozoite Protein by Substituting Proline for (S)-.alpha.-Methylproline

Christian Bisang; Christoph Weber; Janice Inglis; Celia A. Schiffer; Wilfred F. van Gunsteren; Ilian Jelesarov; Hans Rudolf Bosshard; John A. Robinson


Journal of Molecular Biology | 1997

Dynamical Studies of Peptide Motifs in the Plasmodium falciparum Circumsporozoite Surface Protein by Restrained and Unrestrained MD Simulations

Alain P. Nanzer; Andrew E. Torda; Christian Bisang; Christoph Weber; John A. Robinson; Wilfred F. van Gunsteren


Journal of the American Chemical Society | 1998

Synthesis, Conformational Properties, and Immunogenicity of a Cyclic Template-Bound Peptide Mimetic Containing an NPNA Motif from the Circumsporozoite Protein of Plasmodium falciparum

Christian Bisang; Luyong Jiang; Ernst Freund; Fabienne Emery; Christian Bauch; Hugues Matile; Gerd Pluschke; John A. Robinson


Helvetica Chimica Acta | 1996

Protein-Loop Mimetics: A Diketopiperazine-Based Template to Stabilize Loop Conformations in Cyclic Peptides Containing the NPNA and RGD Motifs

Christian Bisang; Christoph Weber; John A. Robinson


Archive | 2014

β-hairpin peptidomimetics

Sophie Barthélémy; Christian Bisang; Frank Gombert; Alexander Lederer; Daniel Obrecht; Barbara Romagnoli; Jürg Zumbrunn; Tobias Remus; Guillaume Lemercier


Archive | 2014

BETA-HAIRPIN PEPTIDOMIMETICS HAVING CXCR4 ANTAGONIZING ACTIVITY

Daniel Obrecht; Frank Gombert; Alexander Lederer; Barbara Romagnoli; Christian Bisang


Archive | 2010

TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY

Frank Gombert; Alexander Lederer; Daniel Obrecht; Barbara Romagnoli; Christian Bisang; Christian Ludin


Archive | 2010

TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY

Françoise Jung; Frank Gombert; Daniel Obrecht; Christian Bisang; Sophie Barthélémy; Alexander Lederer; Eric Chevalier

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Wilfred F. van Gunsteren

École Polytechnique Fédérale de Lausanne

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