Christian Furlan Freguia
Children's Hospital of Philadelphia
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Christian Furlan Freguia.
Journal of Thrombosis and Haemostasis | 2005
Alexander Schlachterman; Joerg Schuettrumpf; Jianhua Liu; Christian Furlan Freguia; Raffaella Toso; Mortimer Poncz; Rodney M. Camire; Valder R. Arruda
Summary. The role of factor V Leiden (FVL) as a modifier of the severe hemophilia phenotype is still unclear. We used mice with hemophilia A or B crossed with FVL to elucidate in vivo parameters of hemostasis. Real‐time thrombus formation in the microcirculation was monitored by deposition of labeled platelets upon laser‐induced endothelial injury using widefield microscopy in living animals. No thrombi formed in hemophilic A or B mice following vascular injuries. However, hemophilic mice, either heterozygous or homozygous for FVL, formed clots at all injured sites. Injection of purified activated FV into hemophilic A or B mice could mimic the in vivo effect of FVL. In contrast to these responses to a laser injury in a microvascular bed, FVL did not provide sustained hemostasis following damage of large vessels in a ferric chloride carotid artery injury model, despite of the improvement of clotting times and high circulating thrombin levels. Together these data provide evidence that FVL has the ability to improve the hemophilia A or B phenotype, but this effect is principally evident at the microcirculation level following a particular vascular injury. Our observations may partly explain the heterogeneous clinical evidence of the beneficial role of FVL in hemophilia.
Molecular Therapy | 2005
Valder R. Arruda; Hansell H. Stedman; Haiyan Jian; Glenn F. Pierce; Joerg Schuettrumpf; Christian Furlan Freguia; Stefano Baila; Kapil Gopal; Timothy C. Nichols; Katherine A. High
Blood | 2005
Joerg Schuettrumpf; Alexander Schlachterman; Jianxiang Zou; Christian Furlan Freguia; Stefano Baila; Valder R. Arruda
Blood | 2011
Joshua I. Siner; Christian Furlan Freguia; Michael Maiden; Jianhua Liu; Stefano Baila; Valder R. Arruda
Blood | 2007
Christian Furlan Freguia; Denise E. Sabatino; Andrey dos Santos; Amy M. Lange; Raffaella Toso; Timothy C. Nichols; Rodney M. Camire; Valder R. Arruda
Molecular Therapy | 2006
Christian Furlan Freguia; Joerg Schuettrumpf; Stefano Baila; Jianhua Liu; Ralph M. Bunte; Rodney M. Camire; Valder R. Arruda
Molecular Therapy | 2006
Stefano Baila; Christian Furlan Freguia; Danielle Dunn; Federico Mingozzi; Joerg Schuettrumpf; Valder R. Arruda
Blood | 2006
Christian Furlan Freguia; Joerg Schuettrumpf; Stefano Baila; Alexander Schlachterman; Jianxang Zou; Shangzhen Zhou; Valder R. Arruda
Molecular Therapy | 2005
Joerg Schuettrumpf; Alexander Schlachterman; Jianxiang Zou; Jianhua Liu; Christian Furlan Freguia; Valder R. Arruda
Blood | 2005
Christian Furlan Freguia; Joerg Schuettrumpf; Stefano Baila; Jianhua Liu; Ralph Bunte; Rodney M. Camire; Valder R. Arruda