Christian Heisel

The Biomechanical Results of Total Hip Resurfacing Arthroplasty

BACKGROUND With the advent of more wear-resistant bearings, there is renewed interest in resurfacing total hip arthroplasty. However, there is a paucity of information on the biomechanical results of this type of arthroplasty compared with those of contemporary total hip arthroplasty. METHODS Using standardized radiographs, we measured and compared the biomechanical parameters that affect the hip joint reactive forces in fifty hips that had a metal-metal surface replacement with those parameters in forty hips that had a contemporary cementless total hip replacement performed during the same time-period by the same surgeon. RESULTS On the average, the arthritic hips that were treated with metal-metal surface replacement had had a more valgus preoperative neck-shaft angle and less horizontal femoral offset than the normal, contralateral hips (p = 0.0003). After both the metal-metal surface replacements and the cementless total hip replacements, the hip center of rotation was medialized by approximately 6 mm. Both procedures were associated with an average increase in limb length of approximately 3 or 4 mm. After the metal-metal surface replacements, the horizontal femoral offset was essentially equal to the preoperative value, but both values averaged about 8 mm less than those on the normal, contralateral side (p < 0.00001). In the hips with a conventional total hip replacement, the horizontal femoral offset increased an average of 9.5 mm compared with the preoperative value and was an average of 5 mm more than that for the normal, contralateral hip (p = 0.001). CONCLUSIONS The biomechanical results of total hip resurfacing depend on the preoperative anatomy of the proximal part of the femur. Limb lengthening of 1 cm can be achieved, but horizontal femoral offset is essentially unchanged by hip resurfacing. Horizontal femoral offset can be increased reliably with a contemporary total hip replacement. Arthritic hips of limbs that are more than 1 cm shorter than the contralateral limb or that have a comparatively low horizontal femoral offset may be better served by a contemporary total hip replacement. These biomechanical limitations should be considered in the selection of hips for resurfacing. LEVEL OF EVIDENCE Therapeutic study, Level III-1 (case-control study). See Instructions to Authors for a complete description of levels of evidence.

Short-term In Vivo Wear Of Cross-linked Polyethylene

BACKGROUND Cross-linked polyethylene was developed to reduce volumetric wear in prosthetic joints. Hip simulator studies have shown promising results with regard to wear reduction. This study evaluated the short-term in vivo wear of a moderately cross-linked polyethylene. METHODS Linear head penetration, as an assessment of in vivo polyethylene wear, was measured in two groups of patients after total hip replacement. Twenty-four hips received a conventional polyethylene insert and thirty-four, a cross-linked polyethylene liner; both inserts were manufactured by the same company. Linear and volumetric wear rates were measured on radiographs with use of a validated computer-assisted technique and were adjusted for patient-related factors. Patient activity was assessed by a computerized two-dimensional accelerometer worn on the ankle. RESULTS Patients with a conventional polyethylene insert showed a mean linear wear rate of 0.13 mm per year and a mean volumetric wear rate of 87.6 mm(3) per year. The group with a cross-linked polyethylene liner showed a mean linear wear rate of 0.02 mm per year and a mean volumetric wear rate of 17.0 mm(3) per year. Wear in the group with cross-linked polyethylene was 81% lower than that in the group with conventional polyethylene (p < 0.00001). Accounting for differences in patient activity, the adjusted wear rates per million cycles for a patient weight of 70 kg were 53 mm(3) per million cycles for conventional polyethylene and 15 mm(3) per million cycles for cross-linked polyethylene, a 72% reduction (p = 0.0002). No factor, other than the type of polyethylene, was found to influence the difference in wear rates between the two groups. CONCLUSIONS The results of this study are promising. The in vivo wear reduction with this cross-linked polyethylene is consistent with the predictions of hip simulator studies.

Bearing surface options for total hip replacement in young patients.

Encouraging results and new implant developments have allowed total hip replacement to be performed in increasingly younger and more active patients. In young patients, however, outcomes are not comparable to those seen in older patients. The inflammatory reaction to polyethylene wear particles is one of the main causes of aseptic loosening and subsequent revision surgery and can limit the longevity of an arthroplasty in young and active patients. The wear resistance of polyethylene has been improved by cross-linking; however, greater degrees of cross-linking are associated with progressive decreases in other material properties, which theoretically increase the risk of component failure from very high or localized stresses. Ceramic femoral heads have been associated with lower in vivo polyethylene wear rates, which have been variable and up to 50% lower than with metallic heads. Metal-on-metal bearings have been reintroduced with improved materials, design, and manufacturing, although theoretical concerns remain regarding long-term exposure to metal particles and ions. Improved ceramic-on-ceramic bearings also are available and have the lowest wear rates. They offer a very small risk of in vivo fracture; however, they are the most expensive bearing option and wear rate is more sensitive to implant position. Long-term clinical studies are needed to show a reduction in revision surgery associated with the use of this current generation of bearings. The use of any of these bearings has specific benefits and risks that should be considered on a patient-by-patient basis.

Cementing Techniques for Hip Resurfacing Arthroplasty: Development of a Laboratory Model

BACKGROUND Hip resurfacing is extremely technique-sensitive, yet scientific investigations into cementing techniques are lacking. In this study, we tested open-cell, reticulated, carbon-foam materials in comparison with paired human femoral heads to validate a laboratory cementing model for resurfacing arthroplasty. METHODS Paired human femoral heads prepared for resurfacing were compared with thirty and sixty-pore-per-inch fat-filled foam specimens. Two different cementing techniques were analyzed: manual application of high-viscosity cement, and half component-filling with low-viscosity cement. Real-time measurements were made of cement pressure and temperature. Cement penetration areas and depths were quantified. RESULTS We found no significant differences between the human femoral heads and the fat-filled thirty-pore-per-inch foam models in all measured variables (pressures at the top, chamfer and outer wall, temperature at the 5-mm and 15-mm subsurface). There was no significant difference in the cement penetration of the human femoral heads and the fat-filled thirty-pore-per-inch foam models. There were a number of significant differences between the human femoral heads and the sixty-pore-per-inch foam models with use of the low-viscosity cement technique. The differences between the cementing techniques were greater than those between the three materials for most of the measurements. CONCLUSIONS Fat-filling (to emulate bone marrow) of lower-density carbon foam more closely simulates the cement penetration resistance and thermal properties of human femoral heads than does the denser (unfilled) material. This model is sensitive to differences in cementing technique.

Characterization of the Running-in Period in Total Hip Resurfacing Arthroplasty: An in Vivo and in Vitro Metal Ion Analysis

BACKGROUND Metal-on-metal total hip resurfacing arthroplasty is increasingly being performed in young and active patients. Preclinical in vitro testing of implants is usually performed with use of hip simulators, and the serum metal ion concentration is determined for the purpose of monitoring the patients. The goal of this study was to characterize the early running-in period in vivo and in vitro by characterizing metal ion levels. METHODS A well-functioning total hip resurfacing prosthesis was implanted in fifteen consecutive patients, and the serum metal ion concentrations in these patients were then determined preoperatively and at intervals during the first postoperative year (at one, six, twelve, twenty-four, and fifty-two weeks). The number of walking cycles was measured with use of a computerized accelerometer in order to compare walking cycles to hip simulator cycles. In vitro, five similar components were investigated for 3 million cycles with use of a hip simulator. Serum samples were obtained at different time points, and wear was measured by quantifying wear particles and ions in the samples. All patient and simulation serum samples were analyzed with use of inductively coupled plasma-mass spectrometry. One simulator implant was investigated with use of scanning electron microscopy. RESULTS The serum chromium and cobalt levels of the patients continuously increased during the first six months and showed an insignificant decrease thereafter. The molybdenum concentration was unchanged compared with preoperative values. In contrast, the simulator measurements showed a different wear pattern with a high-wear running-in period and a low-wear steady-state phase. The running-in period was delayed by 300,000 cycles and lasted up to 1 million cycles. Scanning electron microscopic analysis showed a carbon-rich protein film predominantly in the early phases of simulation. Scratches were detected originating from pits filled with aluminum oxide and silicon oxide and from pulled-out carbides that were causing third-body wear. CONCLUSIONS The simulator study allowed an exact characterization of the running-in period and showed a delayed onset of running-in wear. In contrast, the clinical data showed a slow increase in measured ion concentrations. These different wear patterns are probably due to the effects of distribution, accumulation, and excretion of particles and ions in vivo.

The relationship between activity and ions in patients with metal-on-metal bearing hip prostheses.

BACKGROUND Total hip replacements with metal-on-metal bearings are frequently implanted in young, active patients. The relationship between patient activity and cobalt and chromium ion levels has not been investigated, to our knowledge. METHODS Seven patients with well-functioning metal-on-metal bearing hip prostheses and one control subject (no implants), all with normal renal function, were monitored during a two-week-long activity protocol. Lower-extremity activity was continuously assessed with use of a computerized, two-dimensional accelerometer. During the first week, the subjects were requested to limit physical activity. The subjects then completed an hour-long treadmill test followed by a week in which they were encouraged to be as physically active as practically possible. Serum levels of cobalt and chromium ions and urine levels of chromium were assessed at ten time-points during these two weeks. RESULTS Regardless of activity, the serum ion levels for a given patient were essentially constant and no correlation was found between patient activity and serum levels of cobalt or chromium, or urine levels of chromium. A mean increase in activity of 28% during the week of high-intensity activity was associated with a mean decrease of 2.7% in the serum cobalt level and a mean increase of 2.0% in the serum chromium level. During the treadmill test, a mean increase in activity of 1621% was associated with a mean increase of 3.0% in the serum cobalt level and a mean increase of 0.8% in the serum chromium level. These results fall within the variability for the measurement accuracy of these tests. CONCLUSIONS For these patients, serum cobalt and chromium ion levels were not acutely affected by patient activity. Periodic measurements of serum ion levels could be used to monitor the tribologic (lubrication, friction, and wear) performance of a metal-on-metal bearing without adjusting for patient activity. Additional research is needed into the kinetics of ion production, transport, and excretion.

Metal release and corrosion effects of modular neck total hip arthroplasty

Modular neck implants are an attractive treatment tool in total hip replacement. Concerns remain about the mechanical stability and metal ion release caused by the modular connection. Five different implant designs were investigated in an experimental set-up. In vivo conditions were simulated and the long-term titanium release was measured. Finally, the modular connections were inspected for corrosion processes and signs of fretting. No mechanical failure or excessive corrosion could be identified for the implants tested. The titanium releases measured were extremely low compared to in vivo and in vitro studies and were not in a critical range.RésuméDans les prothèses totales de hanche l’utilisation d’implants avec col modulaire est d’une utilisation fréquente et pratique. Néanmoins, cette utilisation laisse persister des doutes sur la stabilité mécanique et sur le relargage des ions métalliques. 5 différents implants ont été étudiés en reproduisant les conditions in vivo, en mesurant le relargage de titane et en évaluant la corrosion et les lésions du col. Ce travail n’a pas permis de mettre en évidence d’échec secondaire à une corrosion excessive, et les taux de titane sont restés extrêmement bas dans les limites de l’acceptable.

Reduction of Osteolysis with Use of Marathon Cross-linked Polyethylene: A Concise Follow-up, at a Minimum of Five Years, of a Previous Report*

We previously reported wear data at a minimum of two years following thirty-four total hip replacements with a Marathon cross-linked polyethylene liner and twenty-four replacements with a conventional (gamma-sterilized-in-air) Enduron polyethylene liner. In this current study, with sequential five-year radiographs, wear rates were determined with use of linear regression analysis. The Marathon polyethylene had average wear rates of 15.4 mm(3)/yr and 8.0 mm(3)/million cycles. The Enduron polyethylene had average wear rates of 55.5 mm(3)/yr and 29.9 mm(3)/million cycles. The adjusted volumetric wear rate of the Marathon polyethylene was 73% lower than that of the Enduron polyethylene (p = 0.001). Osteolysis developed in eight of the twenty-four hips with an Enduron liner but was not apparent in any hip with a Marathon liner.

The effects of lower-extremity total joint replacement for arthritis on obesity.

Total hip or knee replacement patients who are overweight or obese often consider their disabling joint disease a cause for their increased weight. This prospective study investigated weight change in 100 patients after successful total joint replacement to determine whether surgical treatment of hip or knee arthritis leads to weight reduction. Postoperatively, both hip and knee replacement patients gained weight, with no difference in weight gain between hip and knee replacement patients. Younger hip patients gained a significant amount of weight. Patients a with normal body mass index and obese patients did not lose weight, while overweight patients gained a significant amount of weight after surgery. These findings demonstrate successful treatment of lower-extremity arthritis does not lead to weight loss, and obesity should be treated as an independent disease that is not the result of inactivity from arthritis.

Medium to long-term results after reconstruction of bone defects at the knee with tumor endoprostheses.

Limb salvage and reconstruction with tumor endoprostheses is considered as therapeutic standard in the treatment of bone defects at the knee. Few studies report long‐term results so far.