Christian Kohlsdorfer

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Featured researches published by Christian Kohlsdorfer.

Bioorganic & Medicinal Chemistry | 2002

Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.

Alexander Straub; Jordi Benet-Buckholz; Rita Fröde; Armin Kern; Christian Kohlsdorfer; Peter D. Schmitt; Thomas Schwarz; Hans-Martin Siefert; Johannes-Peter Stasch

The pyrazolopyridine stimulators of soluble guanylate cyclase BAY 41-2272 and 41-8543 were oxidised in rats and dogs at their 5-pyrimidinyl-cyclopropyl and -morpholino residue. These metabolites activate the soluble guanylate cyclase, induce vasoelaxation and thereby may contribute to the in vivo activity of BAY 41-2272 and BAY 41-8543.

Journal of Pharmaceutical Sciences | 2004

High-throughput determination of the free fraction of drugs strongly bound to plasma proteins

Joachim Schuhmacher; Christian Kohlsdorfer; Klaus Bühner; Tim Brandenburger; Renate Kruk

Archive | 1989

Substituted 4-(quinolin-2-yl-methoxy)phenyl-acetic-acid derivatives

Klaus Mohrs; Siegfried Raddatz; Elisabeth Perzborn; Romanis Fruchtmann; Christian Kohlsdorfer; Reiner Muller-Peddinghaus; Pia Theisen

Archive | 1989

Substituted 4-(quinolin-2-yl-methoxy)phenyl-acetic acid derivatives and anti-allergic use thereof

Klaus Mohrs; Siegfried Raddatz; Elisabeth Perzborn; Romanis Fruchtmann; Christian Kohlsdorfer; Reiner Muller-Peddinghaus; Pia Theisen

Archive | 1987

Substituted phenyl-sulphon amides

Klaus Mohrs; Elisabeth Perzborn; Friedel Seuter; Romanis Dipl.-Biologin Fruchtmann; Christian Kohlsdorfer

Archive | 1990

Substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphon-amides and -cyanamides, processes for their preparation and their use in medicaments

Siegfried Raddatz; Klaus-Helmut Mohrs; R. Fruchtmann; Christian Kohlsdorfer; Pia Theisen-Popp; Reiner Muller-Peddinghaus

Archive | 1992

2-Substituted quinolines, process for their preparation as well as their use in medicaments

Siegfried Raddatz; Klaus-Helmut Mohrs; Michael Matzke; Romanis Fruchtmann; Armin Hatzelmann; Christian Kohlsdorfer; Reiner Muller-Peddinghaus; Pia Theisen-Popp

Archive | 1990