Christian Moretti

Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae).

In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10microg/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3microM to 37.2microM.

Triterpenoid saponins from the fruits of Caryocar villosum.

Fourteen new triterpenoid saponins (1-14) were isolated from the methanol extract of the fruits of Caryocar villosum along with 10 known saponins. Their structures were established on the basis of extensive NMR (1H, 13C, COSY, TOCSY, ROESY, HSQC, and HMBC) and ESIMS studies. The toxicity of the methanolic extracts of the peel and the pulp of fruits and the crude saponin fraction of the peel was assessed using the Artemia salina test. The antimicrobial activities of caryocarosides IV-21 (14), II-1 (16), III-1 (17), and IV-9 (20) and of saponin 23 were also studied in vitro on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Mycobacterium smegmatis, and Enterococcus faecalis bacteria.

Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).

In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The ethyl acetate extract obtained from the root barks of Symphonia globulifera exhibited a strong antiplasmodial activity (97% at 10 microg/ml). The phytochemical investigation of this extract led to the isolation of nine polycyclic polyprenylated acylphloroglucinol (PPAPs) compounds and two oxidized derivatives. All compounds showed antiplasmodial activity with IC(50)s ranged from 2.1 to 10.1 microM. A LC/ESI-MS(n) study performed on polyprenylated benzophenones previously isolated from Moronobea coccinea provided a reliable method for their detection in the extract and structural elucidation.

4-Quinolinone alkaloids from Dictyoloma peruviana

The stem-bark of Dictyoloma peruviana yielded two new piperidino [1,2-a] 4-quinolinones, dictyolomide A and dictyolomide B. Their structures were established by NMR spectroscopy.

Isolation and structure (x-ray analysis) of karinolide, a new quassinoid from Simaba Multiflora ☆

Karinolide is a structurally novel C20 quassinoid isolated from the French Guyanan Simaroubaceae, Simaba multiflora A.Juss. whose structure was established by X-ray diffraction analysis. 6α-Senecioyloxychaparrin , the known 6α-senecioloyxychaparrinone and 9-methoxycanthin-6-one were also isolated ; their structure were determined by spectral means.

Isoflavanoid constituents from Dalbergia monetaria

Abstract The structures and isolation of eight compounds from Dalbergia monetaria seeds are described. Four of them are known rotenoids. In addition to a new isoflavone and its 7-β- D -glucoside, the first 12-dihydrorotenone, 12-dihydrodalbinol, and its 8′-β- D -glucoside were identified.

Structures of simarinolide and guanepolide (x-ray analysis), new quassinoids from cf

Abstract Simarinolide 4a and Guanepolide 5a are new quassinoids with a C25 basic skeleton isolated from a member of the French Guyanan Simaroubaceae, Simaba cf orinocensis H.B.K. The structure 4a was established by spectral means and that of 5a by X-ray diffraction analysis. The previously known simarolide 1 was also isolated.

An indole alkaloid from Strychnos erichsonii

Abstract Erichsonine is a new indole alkaloid isolated from the stem bark of Strychnos erichsonii . Its structure has been established by spectral means and confirmed by X-ray crystallographic analysis. This is the first report of a vobasine-type alkaloid from the Loganiaceae.

Phenolic Glycosides from the Stem Bark of Caryocar villosum and C. glabrum

Mushroom tyrosinase inhibitory activity of methanol extracts and polar fractions of the stem bark of Caryocar villosum and C. glabrum has been assessed. Seven new phenolic glycosides (1-7) were isolated from the most active fractions, along with 15 known compounds (8-22). The structures of these compounds were established on the basis of spectroscopic methods including 1D and 2D NMR analysis, HRESIMS, and comparison with literature experimental data for known compounds.