Christian Wolpert

Further Insights into the Effect of Quinidine in Short QT Syndrome Caused by a Mutation in HERG

Introduction: The principal aim of this study was to assess the efficacy of quinidine in suppressing IKr in vitro and in modulating the rate dependence of the QT interval in the “SQT1” form of the short QT syndrome.

Congenital short QT syndrome and implantable cardioverter defibrillator treatment: inherent risk for inappropriate shock delivery.

Introduction: A congenital short QT interval constitutes a new primary electrical abnormality associated with syncope and/or sudden cardiac death. We report on the initial use of implantable cardioverter defibrillator (ICD) therapy in patients with inherited short QT interval and discuss sensing abnormalities and detection issues.

Markers of Myocardial Damage, Tissue Healing, and Inflammation After Radiofrequency Catheter Ablation of Atrial Tachyarrhythmias

Introduction: Radiofrequency ablation produces a localized endomyocardial necrosis that may result in release of biochemical markers reflecting myocardial cell damage, inflammation, and tissue reparation. The aim of this study was to determine the extent of rise and time course of markers of inflammation and tissue reparation in patients undergoing radiofrequency catheter ablation.

In vivo effects of mutant HERG K+ channel inhibition by disopyramide in patients with a short QT-1 syndrome: a pilot study.

Introduction: Quinidine has been evaluated in patients with a short QT‐1 syndrome caused by an IKr gain‐of‐function mutation of HERG. Recently, in vitro data with disopyramide showed an even stronger effect on the N588K mutant current. The aim of the present study was to test the in vivo effects of disopyramide in patients with short QT‐1 syndrome caused by a N588K mutation in HERG.

Prevalence of supraventricular tachyarrhythmias in a cohort of 115 patients with Brugada syndrome.

Background: The Brugada syndrome is characterized by ST segment elevation in leads V1 to V3 and a right bundle branch block like pattern. It is associated with an increased risk of syncope and sudden cardiac death. Initial reports in small numbers of patients suggest an association between supraventricular tachycardias and Brugada syndrome with a prevalence varying between 13% and 40%.

Electrical proarrhythmia: induction of inappropriate atrial therapies due to far-field R wave oversensing in a new dual chamber defibrillator.

R Wave Far‐Field Sensing in Dual Chamber Defibrillators. This case report describes delivery of atrial therapies during a sinus tachycardia in a new dual chamber implantable cardioverter defibrillator inappropriately caused by far‐field oversensing of ventricular beats in the atrial channel. Upon classification of the PR interval pattern, the rate criterion for an atrial tachycardia was fulfilled, and the device initiated high‐frequency burst pacing as the first stage of programmed tiered atrial therapies. Atrial fibrillation subsequently was induced by high‐frequency burst pacing, and eventually a programmed 10‐J shock was delivered for successful termination of atrial fibrillation. The phenomenon of far‐field oversensing of ventricular beats could be repeatedly observed during exercise testing and abolished by decreasing the atrial sensitivity.

Are Women with Severely Symptomatic Brugada Syndrome Different from Men

Introduction: Spontaneous type‐1 ECG has been recognized as a risk factor for sudden cardiac death (SCD) in Brugada syndrome (BrS), but studied populations predominantly consisted of men. We sought to investigate whether a spontaneous type‐1 ECG pattern was also associated in women with severely symptomatic BrS. Other known risk factors were also examined for gender specificity.

Diagnostic Performance of a Dual‐Chamber Cardioverter Defibrillator Programmed with Nominal Settings: A European Prospective Study

Arrhythmia Discrimination by ICD. Introduction: Despite technologic developments, accurate discrimination of ventricular tachyarrhythmia from rapid rhythms of nonventricular origin remains a challenge. We sought to examine the sensitivity and specificity of a dual‐chamber arrhythmia detection algorithm, the PARAD algorithm, incorporated in a dual‐chamber implantable cardioverter defibrillator, the Defender (ELA Medical).

A New Classification Algorithm for Discrimination of Ventricular from Supraventricular Tachycardia in a Dual Chamher Implantable Cardioverter Defibrillator

New Atrioventricular Classification Algorithm. Introduction: The high incidence of inappropriate therapies due to supraventricular tachycardia remains a major unsolved problem of implantable cardioverter defibrillators. We report a new detection formula for discrimination of ventricular tachycardia from supraventricular tachycardia in a patient with a dual chamber implantable cardioverter defibritlator and a new atrioventricular classification algorithm.

Enhanced Coagulation Activation by In Vitro Lipopolysaccharide Challenge in Patients with Ventricular Fibrillation Complicating Acute Myocardial Infarction

Background: Indicators of coagulation and inflammation are elevated in patients with coronary heart disease. A role of coagulation activation in ventricular fibrillation during acute myocardial infarction has not been described.