Christina Louise Leone

Malonyl α-mercaptoketones and α-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors

Abstract A novel series of matrix metalloproteinase (MMP) inhibitors is described. Incorporation of a terminal α-mercaptoketone or α-mercaptoalcohol in the zinc binding domain of a series of inhibitors led to compounds exhibiting low nanomolar activity against collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).

Preparation and antibacterial activity of pyridopyridone analogs: C-1 modifications

Abstract Variation of the C-1 position of the pyridopyridone antibacterials shows a sensitivity to both size and electronic character of the substituent.