Christine A. Goeschel

Sustaining reductions in catheter related bloodstream infections in Michigan intensive care units: observational study

Objectives To evaluate the extent to which intensive care units participating in the initial Keystone ICU project sustained reductions in rates of catheter related bloodstream infections. Design Collaborative cohort study to implement and evaluate interventions to improve patients’ safety. Setting Intensive care units predominantly in Michigan, USA. Intervention Conceptual model aimed at improving clinicians’ use of five evidence based recommendations to reduce rates of catheter related bloodstream infections rates, with measurement and feedback of infection rates. During the sustainability period, intensive care unit teams were instructed to integrate this intervention into staff orientation, collect monthly data from hospital infection control staff, and report infection rates to appropriate stakeholders. Main outcome measures Quarterly rate of catheter related bloodstream infections per 1000 catheter days during the sustainability period (19-36 months after implementation of the intervention). Results Ninety (87%) of the original 103 intensive care units participated, reporting 1532 intensive care unit months of data and 300 310 catheter days during the sustainability period. The mean and median rates of catheter related bloodstream infection decreased from 7.7 and 2.7 (interquartile range 0.6-4.8) at baseline to 1.3 and 0 (0-2.4) at 16-18 months and to 1.1 and 0 (0.0-1.2) at 34-36 months post-implementation. Multilevel regression analysis showed that incidence rate ratios decreased from 0.68 (95% confidence interval 0.53 to 0.88) at 0-3 months to 0.38 (0.26 to 0.56) at 16-18 months and 0.34 (0.24-0.48) at 34-36 months post-implementation. During the sustainability period, the mean bloodstream infection rate did not significantly change from the initial 18 month post-implementation period (−1%, 95% confidence interval −9% to 7%). Conclusions The reduced rates of catheter related bloodstream infection achieved in the initial 18 month post-implementation period were sustained for an additional 18 months as participating intensive care units integrated the intervention into practice. Broad use of this intervention with achievement of similar results could substantially reduce the morbidity and costs associated with catheter related bloodstream infections.

Reality check for checklists

This paper was published as The Lancet, 2009, 374 (9688), pp. 444-445. It is available from http://www.sciencedirect.com/science/journal/01406736. DOI: 10.1016/S0140-6736(09)61440-9

Improving patient safety in intensive care units in Michigan.

PURPOSE The aim of this study was to describe the design and lessons learned from implementing a large-scale patient safety collaborative and the impact of an intervention on teamwork climate in intensive care units (ICUs) across the state of Michigan. MATERIALS AND METHODS This study used a collaborative model for improvement involving researchers from the Johns Hopkins University and Michigan Health and Hospital Association. A quality improvement team in each ICU collected and submitted baseline data and implemented quality improvement interventions. Primary outcome measures were improvements in safety culture scores using the Teamwork Climate Scale of the Safety Attitudes Questionnaire (SAQ); 99 ICUs provided baseline SAQ data. Baseline performance for adherence to evidence-based interventions for ventilated patients is also reported. The intervention to improve safety culture was the comprehensive unit-based safety program. The rwg statistic measures the extent to which there is a group consensus. RESULTS Overall response rate for the baseline SAQ was 72%. Statistical tests confirmed that teamwork climate scores provided a valid measure of teamwork climate consensus among caregivers in an ICU, mean rwg was 0.840 (SD = 0.07). Teamwork climate varied significantly among ICUs at baseline (F98, 5325 = 5.90, P < .001), ranging from 16% to 92% of caregivers in an ICU reporting good teamwork climate. A subset of 72 ICUs repeated the culture assessment in 2005, and a 2-tailed paired samples t test showed that teamwork climate improved from 2004 to 2005, t(71) = -2.921, P < .005. Adherence to using evidence-based interventions ranged from a mean of 25% for maintaining glucose at 110 mg/dL or less to 89% for stress ulcer prophylaxis. CONCLUSION This study describes the first statewide effort to improve patient safety in ICUs. The use of the comprehensive unit-based safety program was associated with significant improvements in safety culture. This collaborative may serve as a model to implement feasible and methodologically rigorous methods to improve and sustain patient safety on a larger scale.

Framework for Patient Safety Research and Improvement

Lapses in patient safety represent a significant global problem that results in preventable morbidity, mortality, and costs of care. In the 1999 landmark report To Err Is Human , the Institute of Medicine shocked the healthcare industry with estimates that up to 98 000 people die because of medical errors each year in the United States.1 This glaring report was amplified by a 2003 RAND study that suggested that hospitalized patients in the United States on average receive only half the recommended therapies.2 The impact of these reports damaged consumer confidence in the healthcare industry and galvanized broad industry support to improve patient safety. Five years after the Institute of Medicine publication, there was increasing concern that little measurable progress had been made to improve patient safety.3–5 Since then, the number of quality- and safety-related activities has grown steadily, but there is still minimal empiric evidence demonstrating progress. Our inability to evaluate progress toward improving patient safety results from poorly articulated safety improvement goals and measures and the absence of a simple yet meaningful framework to identify and prioritize the most effective and efficient patient safety interventions. The present report presents a framework to help organize future patient safety research and improvement efforts. We sought to develop a framework for patient safety research and improvement that would address many issues emerging from an expanding international appetite for higher-quality and safer care. We acknowledge that the boundaries between safety and the broader concept of quality remain poorly defined. As we developed and revised this framework, we reflected on our experiences, revisited the Institute of Medicine’s strategies for improvement, and studied the literature on knowledge transfer and diffusion of innovation.6–14 The framework presented includes the following 5 domains (Table 1): (1) evaluating progress in patient safety; (2) translating …

Collaborative Cohort Study of an Intervention to Reduce Ventilator-Associated Pneumonia in the Intensive Care Unit

OBJECTIVE To evaluate the impact of a multifaceted intervention on compliance with evidence-based therapies and ventilator-associated pneumonia (VAP) rates. DESIGN Collaborative cohort before-after study. SETTING Intensive care units (ICUs) predominantly in Michigan. INTERVENTIONS We implemented a multifaceted intervention to improve compliance with 5 evidence-based recommendations for mechanically ventilated patients and to prevent VAP. A standardized CDC definition of VAP was used and maintained at each site, and data on the number of VAPs and ventilator-days were obtained from the hospitals infection preventionists. Baseline data were reported and postimplementation data were reported for 30 months. VAP rates (in cases per 1,000 ventilator-days) were calculated as the proportion of ventilator-days per quarter in which patients received all 5 therapies in the ventilator care bundle. Two interventions to improve safety culture and communication were implemented first. RESULTS One hundred twelve ICUs reporting 3,228 ICU-months and 550,800 ventilator-days were included. The overall median VAP rate decreased from 5.5 cases (mean, 6.9 cases) per 1,000 ventilator-days at baseline to 0 cases (mean, 3.4 cases) at 16-18 months after implementation (P < .001) and 0 cases (mean, 2.4 cases) at 28-30 months after implementation (P < .001). Compared to baseline, VAP rates decreased during all observation periods, with incidence rate ratios of 0.51 (95% confidence interval, 0.41-0.64) at 16-18 months after implementation and 0.29 (95% confidence interval, 0.24-0.34) at 28-30 months after implementation. Compliance with evidence-based therapies increased from 32% at baseline to 75% at 16-18 months after implementation (P < .001) and 84% at 28-30 months after implementation (P < .001). CONCLUSIONS A multifaceted intervention was associated with an increased use of evidence-based therapies and a substantial (up to 71%) and sustained (up to 2.5 years) decrease in VAP rates.

Assessing and improving safety climate in a large cohort of intensive care units

Objectives:To evaluate the impact of a comprehensive unit-based safety program on safety climate in a large cohort of intensive care units participating in the Keystone intensive care unit project. Design/Setting:A prospective cohort collaborative study to improve quality of care and safety culture by implementing and evaluating patient safety interventions in intensive care units predominantly in the state of Michigan. Interventions:The comprehensive unit-based safety program was the first intervention implemented by every intensive care unit participating in the collaborative. It is specifically designed to improve the various elements of a units safety culture, such as teamwork and safety climate. We administered the validated Safety Attitudes Questionnaire at baseline (2004) and after 2 yrs of exposure to the safety program (2006) to assess improvement. The safety climate domain on the survey includes seven items. Measurements and Main Results:Post-safety climate scores for intensive care units. To interpret results, a score of <60% was in the “needs improvement” zone and a ≥10-point discrepancy in pre-post scores was needed to describe a difference. Hospital bed size, teaching status, and faith-based status were included in our analyses. Seventy-one intensive care units returned surveys in 2004 and 2006 with 71% and 73% response rates, respectively. Overall mean safety climate scores significantly improved from 42.5% (2004) to 52.2% (2006), t = −6.21, p < .001, with scores higher in faith-based intensive care units and smaller-bed-size hospitals. In 2004, 87% of intensive care units were in the “needs improvement” range and in 2006, 47% were in this range or did not score ≥10 points or higher. Five of seven safety climate items significantly improved from 2004 to 2006. Conclusions:A patient safety program designed to improve teamwork and culture was associated with significant improvements in overall mean safety climate scores in a large cohort of 71 intensive care units. Research linking improved climate scores and clinical outcomes is a critical next step.

The Wisdom and Justice of Not Paying for “Preventable Complications”

FAR TOO MANY PATIENTS EXPERIENCE PREVENTABLE HARM from medical care in US hospitals. To promote quality and safety, many employers and insurers are linking financial incentives to clinical performance. These programs, often called pay for performance, use a carrot (pay more for better quality) or a stick (pay less for lower quality). To date, most pay-for-performance programs have encouraged physicians to use evidence-based interventions or improve patient satisfaction. The Centers for Medicare & Medicaid Services (CMS) has taken the lead, with many insurers following, in linking pay for performance to reducing harm. In October 2008, hospitals will no longer derive additional payments they sometimes receive when Medicare patients develop 1 of the following 8 preventable complications: objects (such as surgical instruments or sponges) left in patients after surgery, hospital-acquired urinary tract infections, central line–associated bloodstream infections, administration of incompatible blood products, air embolism, patient falls, mediastinitis after cardiac surgery, and pressure ulcers. In addition, CMS has published that conditions being considered for 2009 expansion of the list include ventilator-associated pneumonia, Staphylococcus aureus septicemia, and deep venous thrombosis or pulmonary embolism. The tacit assumption to the “not paid for preventable complications” approach is that an error occurred in a patient’s care that, if avoided, would have prevented the harm and ensuing costs. For one complication on the CMS list, foreign objects inadvertently left in patients after surgery, this is undeniably true. Linking errors to harm for the remaining complications is more complex. For strategies built around the “not paid for preventable complications” concept to be clinically and morally acceptable and to achieve the policy goal of improving quality of care, it must be certain that preventable complications are important and measurable and truly are preventable. In this Commentary, we discuss the CMS initiative in the context of these metrics. Complications Should Be Important and Measurable

Impact of a national multimodal intervention to prevent catheter-related bloodstream infection in the ICU: The Spanish experience

Objective:Prevention of catheter-related bloodstream infection is a basic objective to optimize patient safety in the ICU. Building on the early success of a patient safety unit-based comprehensive intervention (the Keystone ICU project in Michigan), the Bacteremia Zero project aimed to assess its effectiveness after contextual adaptation at large-scale implementation in Spanish ICUs. Design:Prospective time series. Setting:A total of 192 ICUs throughout Spain. Patients:All patients admitted to the participating ICUs during the study period (baseline April 1 to June 30, 2008; intervention period from January 1, 2009, to June 30, 2010). Intervention:Engagement, education, execution, and evaluation were key program features. Main components of the intervention included a bundle of evidence-based clinical practices during insertion and maintenance of catheters and a unit-based safety program (including patient safety training and identification and analysis of errors through patient safety rounds) to improve the safety culture. Measurements and Main Results:The number of catheter-related bloodstream infections was expressed as median and interquartile range. Poisson distribution was used to calculate incidence rates and risk estimates. The participating ICUs accounted for 68% of all ICUs in Spain. Catheter-related bloodstream infection was reduced after 16–18 months of participation (median 3.07 vs 1.12 episodes per 1,000 catheter-days, p < 0.001). The adjusted incidence rate of bacteremia showed a 50% risk reduction (95% CI, 0.39–0.63) at the end of the follow-up period compared with baseline. The reduction was independent of hospital size and type. Conclusions:Results of the Bacteremia Zero project confirmed that the intervention significantly reduced catheter-related bloodstream infection after large-scale implementation in Spanish ICUs. This study suggests that the intervention can also be effective in different socioeconomic contexts even with decentralized health systems.

Reducing Health Care Hazards: Lessons From The Commercial Aviation Safety Team

The movement to improve quality of care and patient safety has grown, but examples of measurable and sustained progress are rare. The slow progress made in health care contrasts with the success of aviation safety. After a tragic 1995 plane crash, the aviation industry and government created the Commercial Aviation Safety Team to reduce fatal accidents. This public-private partnership of safety officials and technical experts is responsible for the decreased average rate of fatal aviation accidents. We propose a similar partnership in the health care community to coordinate national efforts and move patient safety and quality forward.

Preventing Bloodstream Infections: A Measurable National Success Story In Quality Improvement

Over the past decade, advances in the quality of care have been slow. One area of success, however, has been in combating central line-associated bloodstream infections. Data from the Centers for Disease Control and Prevention suggest that the number of patients in US intensive care units suffering a central-line infection declined by 63 percent between 2001 and 2009. We describe the multistep process taken by many stakeholders-states, federal agencies, hospital associations, regulatory and nonprofit associations, clinicians, and local hospitals-to collaborate on the successful reduction and eradication of these infections. Having begun in Michigan, this program has spread to forty-five states, has shown sustained results in reducing hospital-associated infections and mortality, and constitutes an important measurable national success story in quality improvement and a model for improving the health and safety of Americans.