Christine Charon
Merck & Co.
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Publication
Featured researches published by Christine Charon.
American Journal of Physiology-regulatory Integrative and Comparative Physiology | 2014
Stephanie Oger-Roussel; Delphine Behr-Roussel; Stéphanie Caisey; Micheline Kergoat; Christine Charon; Annick M. Audet; Jacques Bernabé; Laurent Alexandre; François Giuliano
Despite the fact that urogenito-sexual complications significantly impact the quality of life of diabetic patients, a robust in vivo experimental model is lacking. Bladder and erectile function in the Type 2 diabetic Goto-Kakizaki (GK) rat and responses to standard-of-care treatments for each disorder have been assessed. GK rats (n = 25, 18-wk-old, GK/Par colony) and age-matched Wistar rats (n = 23), characterized for their metabolic parameters, were used. Bladder function was assessed by cystometry in conscious rats treated by intravenous solifenacin (1 mg/kg). Subsequently, erectile function was assessed under anesthesia following electrical stimulation of the cavernous nerve in presence of intravenous sildenafil (0.3 mg/kg). GK rats displayed detrusor overactivity with a significant increase in frequency/amplitude of nonvoiding contractions during the filling phase, together with an increase in bladder capacity, intercontraction interval, voided volume, and maximal pressure of voiding contraction. Solifenacin significantly decreased parameters characterizing voiding contractions without modifying voiding efficiency. Erectile function in GK rats was markedly impaired and remained so after sildenafil treatment despite a significant improvement. GK rats display both bladder and erectile dysfunctions and respond at least partially to standard-of-care treatments for each disorder, thus representing a suitable model to investigate the pathophysiology and assess the efficacy of new therapeutic agents for Type 2 diabetes-associated bladder and erectile complications.
Archive | 2006
Denis Carniato; Christine Charon; Johannes Gleitz; Didier Roche; Bjoern Hock
Archive | 2007
Didier Roche; Denis Carniato; Liliane Doare; Christine Charon; Caroline Lerich
Archive | 2009
Daniel Cravo; Franck Lepifre; Sophie Hallakou-Bozec; Christine Charon
Archive | 2007
Gerard Moinet; Dominique Marais; Sophie Hallakou-Bozec; Christine Charon
Archive | 2007
Denis Carniato; Caroline Leriche; Didier Roche; Christine Charon; Liliane Doare
Archive | 2006
Sophie Hallakou-Bozec; Christine Charon; Bjoern Hock; Oliver Poeschke
Archive | 2009
Caroline Leriche; Denis Carniato; Didier Roche; Christine Charon; Liliane Doare
Archive | 2009
Gerard Botton; Eric Valeur; Micheline Kergoat; Christine Charon; Samer Elbawab
Archive | 2008
Lars Thore Burgdorf; Norbert Beier; Johannes Gleitz; Christine Charon; Daniel Cravo