Christine Gibbs

A Lymphomatoid Granulomatosis of the Lungs in Young Dogs

Clinical signs in three young dogs with primary lung neoplasms included cough, weight loss and anorexia. Chest radiographs taken in the terminal stages of the disease showed nodular and diffuse consolidation of the lungs typical of primary neoplasms. Macroscopically the lungs were infiltrated by firm, pale tissue; similar tissue replaced the enlarged bronchial lymph nodes. In two dogs similar deposits were found also in the liver and spleen. The infiltrates were composed of atypical, polymorphous lymphoreticular cells. Invasion of pulmonary blood vessels and of bronchi and bronchioles was striking. The lesions closely resembled those of lymphomatoid granulomatosis, a rare human disease of unknown cause.

Pathology of acute respiratory distress in the dog associated with paraquat poisoning

Abstract The morbid anatomical, histological and ultrastructural changes in the lungs of 10 dogs with acute respiratory distress are described. The duration of signs varied from 12 h to 7 days. The early phase of respiratory distress was associated with pulmonary haemorrhage and oedema, focal necrosis of bronchiolar epithelium, alveolar collapse and loss of both type I and type II pneumonocytes. In the later stages there was intra-alveolar fibrosis, bronchiolar epithelial regeneration and alveolar epithelialization by immature type II pneumonocytes. Paraquat was recovered from 4 of the dogs and the similarity between the clinical and pathological features within the group, and to paraquat poisoning in other species, suggested that this compound was probably responsible for the lesions in all 10 dogs. Histological changes also included necrosis of the adrenal zona glomerulosa, renal tubular necrosis, focal myocardial necrosis and medial fibrinoid necrosis of coronary arteries, a change not hitherto described in association with paraquat poisoning. The lesions are discussed in relation to their possible functional role in the development of clinical signs, and are compared with the lesions of paraquat poisoning which have been described in man and laboratory animals.

Megaloesophagus and associated gastric heterotopia in the cat.

Two young adult male Siamese cats had heterotopic gastric mucosa in the dilated and inflamed oesophagi. Normally differentiated gastric mucosal glands were present and there was severe ulceration in one cat. It is uncertain whether the gastric heterotopia was a reparative change after oesophagitis or whether it represented a coincidental anatomical anomaly.

Hamartomatous Polyps in the Intestine of Two Dogs

Partly obstructing, proliferative mucosal masses in the small intestine of two dogs were shown histologically to be hamartomatous polyps. They were characterized by an extension of smooth muscle from the muscularis mucosae into the lamina propria of the lesion. This is the first report of such lesions in domestic animals. In one of the dogs the lesion had become malignant.