Christine Tsunehara

Elevated Plasma Glucose and Lowered Triglyceride Levels From Omega-3 Fatty Acid Supplementation in Type II Diabetes

We studied the effect of omega-3 fatty acids (ω3FA) on glucose homeostasis and lipoprotein levels in eight type II (non-insulin-dependent) diabetic subjects ingesting 8 g/day to3FA for 8 wk as marine-lipid concentrate capsules. After ω3FA supplementation, fasting plasma glucose levels increased 22% (P = .005) and meal-stimulated glucose increased 35% (P = .036). The percentage of glucose elevation correlated with percentage ideal body weight (r = .73, P = .04). No significant changes were seen in fasting or meal-stimulated plasma insulin, glucose disposal, or insulin-to-glucagon ratios. Very-low-density lipoprotein cholesterol and triglyceride (TG) levels showed consistent reductions of 56% (P < .001) and 42% (P < .001), respectively, after ω3FA supplementation. Total cholesterol levels decreased 7% (P < .05) without alteration in low- or high-density lipoprotein cholesterol. Thus, ω3FA supplementation at a dose of 8 g/day significantly improves plasma TG levels but increases fasting and meal-stimulated glucose concentrations in the type II diabetic patient not treated with insulin or sulfonylurea agents. Marine-lipid concentrate capsules supplying large amounts of ω3FAs should be used cautiously in the type II diabetic patient.

Diabetes and diabetes risk factors in second- and third-generation Japanese Americans in Seattle, Washington

In Seattle, Washington, the prevalence of diabetes was 20% in second-generation (Nisei) Japanese-American men and 16% in Nisei women 45-74 years old, while the prevalence of impaired glucose tolerance (IGT) was 36% in Nisei men and 40% in Nisei women. Hyperglycemia was less and duration of diabetes shorter in women. Related to diabetes and IGT in Nisei were higher fasting plasma insulin levels and central (visceral) adiposity. Prevalence of diabetes was low among the younger (34-53 years old) third-generation (Sansei) men and women. Among self-reported non-diabetic Sansei, however, prevalence of IGT was 19% in men and 29% in women, and IGT was associated with both increased fasting plasma insulin levels and more visceral fat, suggesting that many Sansei are at risk of future diabetes. An important lifestyle factor in the development of NIDD in Japanese Americans appeared to be dietary saturated (animal) fat. Another factor may be physical inactivity. In Japanese-American women, menopause also appeared to be an important risk factor. These risk factors may be related to fostering the accumulation of visceral fat and the development of insulin resistance. Five-year follow-up examinations performed in non-diabetic Nisei men and women have yielded additional information concerning the prognosis of IGT. Of those women who were IGT at baseline, 34% were diabetic at follow-up while 17% returned to normal. In men who had been IGT at baseline, 18% were diabetic at follow-up while 36% returned to normal. Over the 5-yr follow-up interval, proportionally more women progressed from normal to IGT (54%) then went from IGT to normal (17%). For men, roughly equal proportions went from normal to IGT (37%) as from IGT to normal (36%). It would therefore appear that greater proportions of Nisei women are progressing to IGT and to NIDD than are Nisei men. This observation may be related to the increased risk of developing central obesity and insulin resistance following menopause. Prevalence of cardiovascular disease (hypertension, peripheral vascular disease, and/or coronary heart disease) was increased in Japanese Americans with IGT and NIDD. Neuropathy and retinopathy were associated only with NIDD.

Baseline dietary intake and physical activity of Japanese American men in relation to glucose tolerance at 5-year follow-up

Japanese American men (n = 124), with normal glucose tolerance (NGT, n = 69) or impaired glucose tolerance (IGT, n = 55) at baseline, were studied for effects of baseline dietary intake and physical activity on glucose tolerance at baseline and at 5‐year follow‐up. At baseline, both NGT and IGT men with positive family history of diabetes (FH) showed high intakes of animal fat and protein, but only the NGT men countered this with high levels of energy expenditure. In the total sample at 5‐year follow‐up, 2‐hour plasma glucose was significantly related to intake of animal fat (AF), partial correlation r = 0.32, P < 0.001, adjusted for total energy intake, age, self‐reported health, body mass index, FH, and baseline glucose tolerance category. Energy expenditure (EE) was not related to 5‐year 2‐hour plasma glucose in the total sample, but displayed a relationship with 5‐year 2‐hour plasma glucose in those IGT (r = −0.27, P < 0.05), but not in those NGT at baseline, and in those with positive FH (r = −0.33, P < 0.05), but not in those with negative FH. Additionally, AF showed a relationship to 5‐year 2‐hour plasma glucose only for those in the lowest (r = 0.37, P < 0.05) and middle (r = 0.33, P < 0.05) tertiles, but not in the highest tertile of EE. For baseline IGT men, 5‐year 2‐hour plasma glucose was related to “high vs. low risk” categories of AF intake and EE, but only in men with a positive FH (AF ≥ 25 vs. < 25 g/day: 180.1 ± 38.6 vs. 143.6 ± 39.7 mg/dl, P = 0.048; EE ≤ 2,000 kcal/week vs. > 2,000 kcal/week, 189.9 ± 39.2 vs. 150.8 ± 37.4 mg/dl, P = 0.028; with risk categories combined, i.e., both high, mixed, both low: 192.0 ± 41.3, 165.4 ± 28.4, 139.4 ± 40.9 mg/dl, P = 0.045, linear trend, P = 0.014). Thus, high AF intake and low EE may have long‐range detrimental effects on glucose tolerance, especially for those with IGT and positive FH.