Christophe Daubie

Enantiospecific synthesis of RPR 107880: A new non peptide substance P antagonist

Abstract The synthesis of enantiomerically pure RPR 107880 is described. The synthesis strategy is based on the use of the readily available and inexpensive (R)-(+)-pulegone.

Practical enantiospecific synthesis of RPR 111905: A novel non-peptide substance P antagonist

Abstract The synthesis of enantiomerically pure RPR 111905 was achieved in twelve steps with an overall yield of 6.9%. The synthetic strategy was based on a Diels-Alder reaction to generate the bicyclic framework and the asymmetry was introduced by resolution.

EXPEDIENT ENANTIOSPECIFIC SYNTHESIS OF RP 73613 : A NEW SELECTIVE NON-PEPTIDE NK1 ANTAGONIST

The synthesis of RP 73613 was achieved in 13 steps with an overall yield of 125. The strategy was based on a [3+2] azomethine ylid dipolar cycloaddition to generate the bicyclic framework and the asymmetry was introduced by resolution.