Christopher C. Schmidt

The effects of platelet-derived growth factor-BB on healing of the rabbit medial collateral ligament : An in vivo study

We report a biologic approach to improve medial collateral ligament healing using growth factors normally expressed in healing tissue. Our previous in vitro work demonstrated that platelet-derived growth factor-BB and transforming growth factor- 1 promoted fibroblast proliferation and matrix synthesis, respectively. Therefore, these growth factors were used in vivo to determine whether they could improve medial collateral ligament healing, whether this effect was dose-dependent, and if combinations of growth factors could improve healing more than individual growth factors. Thirty-seven rabbits had various doses of growth factors applied to the ruptured right medial collateral ligaments using a fibrin sealant delivery vehicle. The five groups consisted of 1) two groups receiving two doses of platelet-derived growth factor-BB, 2) two groups receiving two doses of this growth factor plus transforming growth factor- 1, and 3) one group receiving fibrin sealant only. After sacrifice at 6 weeks, biomechanical and histologic evaluations of the healing ligament were performed. Femur-medial collateral ligament-tibia complexes of the knees given the higher dose of platelet-derived growth factor-BB had ultimate load, energy absorbed to failure, and ultimate elongation values that were 1.6, 2.4, and 1.6 times greater than the same complexes of the control group. Adding transforming growth factor- 1 did not lead to any further increases in the structural properties of the complex compared with treatment with platelet-derived growth factor-BB. These encouraging results suggest that use of platelet-derived growth factor-BB may improve the quality of the healing medial collateral ligament, and that it may also have a similar potential for promoting healing of other ligaments.

Reverse Shoulder Arthroplasty

The reverse shoulder arthroplasty is considered to be one of the most significant technological advancements in shoulder reconstructive surgery over the past 30 years. It is able to successfully decrease pain and improve function for patients with rotator cuff-deficient shoulders. The glenoid is transformed into a sphere that articulates with a humeral socket. The current reverse prosthesis shifts the center of rotation more medial and distal, improving the deltoids mechanical advantage. This design has resulted in successful improvement in both active shoulder elevation and in quality of life.

Plain Radiographs Are Inadequate to Identify Overlengthening With a Radial Head Prosthesis

PURPOSE A correctly sized radial head implant helps restore more normal elbow motion and load distribution and allows the collateral ligaments to heal in an anatomic position. No single method of measurement has been agreed on. We hypothesized that plain radiographs could be used to evaluate the appropriate length of a radial head prosthesis when we simulated different patterns of ligament disruption. METHODS Osteotomies of the medial and lateral condyles were created in 6 cadaver specimens to simulate 4 conditions: ulnar collateral ligament (UCL) and lateral ulnar collateral ligament (LUCL) intact, UCL intact, LUCL intact, and UCL and LUCL disrupted. Radial heads were resected and replaced with correctly or incorrectly sized monopolar radial head implants. Radiographs were taken after simulated ligament injury with a radial head prosthesis that was either 2 mm too short, the appropriate length, or too long by either 2 or 4 mm. Measurements were recorded between radiographic markers to determine ulnohumeral joint displacement. A 4 x 4 x 2 repeated-measures analysis of variance was performed, as well as post hoc analyses using Tukeys honest significant difference test, to determine statistically significant changes in our radiographic measurements. RESULTS Results showed that disruption of at least 1 ligament alters the ulnohumeral joint separation on the lateral but not on the anteroposterior radiograph. Overlengthening the radial head did not result in a statistically significant change in ulnohumeral space. CONCLUSIONS Replicating radial length is an important but sometimes difficult step during radial head replacement. Standard radiographic assessment of the ulnohumeral joint will not demonstrate marked changes in the ulnohumeral space when the implant is underlengthened by 2 mm or overlengthened by as much as 4 mm, as long as the joint remains located. Disruption of at least 1 collateral ligament alters the ulnohumeral joint separation on the lateral but not on the anteroposterior radiograph.

The Distal Biceps Tendon

Distal biceps tendon ruptures continue to be an important injury seen and treated by upper extremity surgeons. Since the mid-1980s, the emphasis has been placed on techniques that limit complications or improve initial tendon-to-bone fixation strength. Recently, basic science research has expanded the knowledge base regarding the biceps tendon structure, footprint anatomy, and biomechanics. Clinical data have further delineated the results of conservative and surgical management of both partial and complete tears in acute or chronic states. The current literature on the distal biceps tendon is described in detail.

Factors affecting supination strength after a distal biceps rupture

HYPOTHESIS This study quantified pain (visual analog pain scale [VAPS]), disability (Disabilities of the Arm, Shoulder and Hand [DASH]) and isometric supination torque at 3 forearm positions in a prospective cohort of biceps-deficient arms to assess the potential for functional return with nonoperative treatment. MATERIALS AND METHODS Twenty-three men (50 ± 11 years) with complete unilateral distal biceps avulsion underwent isometric supination strength testing of both limbs at 60° of supination, 0° (neutral), and 60° of pronation. After exclusion of 1 outlier patient, the mean time from injury to evaluation was 44 days (range, 4-455 days). Pain level (VAPS) and functional outcome (DASH) were assessed; supination strength was normalized to the uninjured arm. RESULTS The uninjured arm was stronger (P < .001), and peak torque varied with forearm position (P < .043). Peak torque was greater in pronation compared with supination, regardless of injury (P < .002). No differences were detected in supination strength as a result of forearm position or arm dominance. Supination strength did not correlate with time from injury to evaluation. One patient regained supination strength (115%) at 60° of pronation and 72% in neutral with a lengthy time from injury. VAPS (5 of 10) and DASH (39 of 100) scores decreased with time and did not relate to supination strength. CONCLUSION Biceps tendon rupture led to a 60% decrease in supination strength in the neutrally oriented forearm. Peak torque observations can be explained using forearm moment arms. VAPS and DASH scores decreased with time but did not affect strength. We speculate that supination strength from pronation to neutral can improve as one strengthens the brachioradialis but strength deficits from neutral to supination are more difficult to overcome.

The Importance of Preserving the Radial Tuberosity During Distal Biceps Repair

BACKGROUND The radial tuberosity contributes to the biceps supination moment arm and the elbow flexion moment. The purpose of our study was to compare the impact of a cortical bone trough versus an anatomic repair on measurements of the forearm supination moment arm and elbow flexion force efficiency. Our hypothesis was that a trough repair would decrease the tuberosity height, the native biceps supination moment arm, and elbow flexion force efficiency compared with an anatomic repair. METHODS The isometric supination moment arm and elbow flexion force efficiency were measured in ten matched pairs of cadaveric upper limbs. After testing, the geometry of the proximal aspect of the radius was reconstructed with use of stereophotogrammetry. All of the repair sites were three-dimensionally reconstructed to quantify the disturbance of the trough on native anatomy. The tuberosity distance was defined as the distance between the central axis of the radius and the centroid of the respective repair site. RESULTS Specimens with a trough repair had a 27% lower supination moment arm at 60° of supination (p = 0.036). There were no differences found for pronation or neutral forearm positioning (p > 0.235). Flexion force efficiency was not significantly different between the trough and anatomic repair groups. The average tuberosity distance was 11.0 ± 2.1 mm for the anatomic repairs and 8.3 ± 1.4 mm for the trough repairs (p = 0.003). The percentage of distance lost due to the trough was 25%. Furthermore, the supination moment arm in the supinated position was significantly correlated with the tuberosity distance. CONCLUSIONS The trough technique resulted in a significant decrease (p = 0.036) in the moment arm of a 60° supinated forearm and a significant reduction (p = 0.003) in radial tuberosity height. The loss of the supination moment arm was correlated with the decrease in tuberosity height, providing evidence that the radial protuberance acts as a mechanical cam. CLINICAL RELEVANCE The anterior protuberance of the radial tuberosity functions as a supination cam; therefore, consideration should be given to preserve its topographical anatomy during a distal biceps repair.

AAOS appropriate use criteria: optimizing the management of full-thickness rotator cuff tears.

The American Academy of Orthopaedic Surgeons (AAOS) has developed the Appropriate Use Criteria (AUC) to determine appropriateness of treatment of full-thickness rotator cuff tears (available at http://www.aaos.org/research/ Appropr iate_Use /rotatorcuf f auc fu l l .pdf ) . An “appropriate” healthcare service is one for which the expected health benefits exceed the expected negative consequences by a sufficiently wide margin. Evidence-based information, in conjunction with the clinical expertise of physicians from multiple medical specialties, was used to develop the criteria to improve patient care and obtain the best outcomes while considering the subtleties and distinctions necessary in making clinical decisions. When there is evidence corroborated by consensus that expected benefits substantially outweigh potential risks, exclusive of cost, a procedure is determined to be appropriate. The AAOS uses the RAND/UCLA Appropriateness Method (RAM).

Factors That Determine Supination Strength Following Distal Biceps Repair

BACKGROUND Supination weakness commonly occurs after a distal biceps repair. The goal of this study was to identify factors that could influence postoperative supination strength through a full arc of forearm rotation. METHODS Fifteen patients were prospectively studied and underwent a biceps repair using a posterior approach; this cohort was compared with a randomized selection of 17 anterior repair subjects. All patients underwent postoperative magnetic resonance imaging (MRI). Quantitative MRI analysis determined the insertion site angle of the tendon and supinator fat content. Supination strength was measured in 3 forearm positions. A multiple linear regression analysis was performed to determine the effect of all factors on supination strength. RESULTS The anterior group had a significantly higher nonanatomic insertion site angle of the tendon than the control group and the posterior group (p < 0.001). The posterior group had significantly greater supinator fat content (p ≤ 0.019) than both the control group and the anterior group. After repair, the posterior group had significantly greater supination strength than the anterior group (p = 0.027). Multiple regression analysis (r = 0.765) found that an anatomic reinsertion of the ruptured tendon (β = 1.159; p < 0.001), posterior approach (β = 0.484; p = 0.043), and limited supinator muscle fat content (β = 0.360; p = 0.013) were significant predictors of the restoration of supination strength in 60° of supination. CONCLUSIONS Future directions for distal biceps tendon repair techniques should focus on restoring an anatomic reattachment site while limiting supinator damage. LEVEL OF EVIDENCE Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

Distal biceps tendon history, updates, and controversies: from the closed American Shoulder and Elbow Surgeons meeting—2015

Understanding of the distal biceps anatomy, mechanics, and biology during the last 75 years has greatly improved the physicians ability to advise and to treat patients with ruptured distal tendons. The goal of this paper is to review the past and current advances on complete distal biceps ruptures as well as controversies and future directions that were discussed and debated during the closed American Shoulder and Elbow Surgeons meeting in 2015.

Arthroscopic Management of Rotator Cuff Calcific Tendonitis

Calcific tendonitis of the rotator cuff is a common cause of shoulder pain and loss of function. When conservative care fails to control pain and restore movement and strength, arthroscopic management is a reliable treatment. The goal of the procedure is removal of the calcific deposit without injury to the intact rotator cuff tendon. Arthroscopic needling, blunt expressing of soft deposits, and limited shaving of firm calcific deposits are the preferred techniques. Complete radiographic removal of the entire calcific deposits is not necessary. High-grade (>50%) partial and complete tears of the rotator cuff created during deposit removal should be repaired by techniques that preserve the intact tendon. Low-grade (<50% of the tendon thickness) partial tears can simply be debrided. Arthroscopic subacromial decompression is performed if impingement signs are present. Significant clinical relief of symptoms can take up to 6–12 months and while it may never be complete radiographic absorption of the deposit can take up to a year.