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Dive into the research topics where Christopher H. Le is active.

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Featured researches published by Christopher H. Le.


International Forum of Allergy & Rhinology | 2016

Practice patterns in endoscopic dacryocystorhinostomy: survey of the American Rhinologic Society.

Sonia Chen; Christopher H. Le; Jonathan Liang

The introduction of advanced endoscopic techniques has facilitated significant growth in endoscopic dacryocystorhinostomy (EnDCR). The purpose of this study is to evaluate clinical practice patterns of otolaryngologists performing EnDCR.


Current Opinion in Otolaryngology & Head and Neck Surgery | 2013

Novel techniques for the diagnosis of Ménière's disease

Christopher H. Le; Anh Q. Truong; Rodney C. Diaz

Purpose of reviewThis review will consider the newly developed and emerging diagnostic techniques with real or potential clinical application to the diagnosis of Ménières disease. Recent findingsSeveral new diagnostic modalities have been introduced, which have the potential to help diagnose endolymphatic hydrops. These include cervical and ocular vestibular evoked myogenic potentials, cochlear hydrops analysis masking procedures, and three-dimensional fluid-attenuated inversion recovery MRI following intratympanic instillation of gadolinium. SummaryDiagnosis of Ménières disease has classically been of a clinical rather than a procedural nature. Despite the many recent advances in diagnostic testing which show potential applicability for aiding in diagnosis of Ménières disease, each has limitations which prevent immediate utility. For now, Ménières disease remains best diagnosed through the standard American Academy of Otolaryngology – Head and Neck Surgery clinical inclusionary and exclusionary criteria.


The Journal of Allergy and Clinical Immunology | 2017

Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis

Eugene H. Chang; Amanda L. Willis; Hilary C. McCrary; George T. Noutsios; Christopher H. Le; Alexander G. Chiu; Corrine Mansfield; Danielle R. Reed; Steven G. Brooks; Nithin D. Adappa; James N. Palmer; Noam G. Cohen; Debra A. Stern; Stefano Guerra; Fernando D. Martinez

A retrospective, multi-center study of adults with and without chronic rhinosinusitis (CRS) identifies a significant association between rs6967330 in the viral receptor CDHR3 – known to be associated with wheezing and asthma in children – and the development of CRS.


Otolaryngologic Clinics of North America | 2017

The Role of Targeted Therapy in the Management of Sinonasal Malignancies

Lawrence Kashat; Christopher H. Le; Alexander G. Chiu

Cancers develop secondary to genetic and epigenetic changes that provide the cell with a survival advantage that promotes cellular immortality. Malignancy arises when tumors use mechanisms to evade detection and destruction by the immune system. Many malignancies seem to elicit an immune response, yet somehow manage to avoid destruction by the cells of the immune system. Cancers may evade this immune response by numerous mechanisms. Several targeted immune therapies are available that block some of these inhibitory signals and enhance the cell-mediated immune response. Many of these agents hold significant promise for future treatment of sinonasal and ventral skull base malignancies.


Advances in oto-rhino-laryngology | 2016

Cystic Fibrosis Sinusitis.

Christopher H. Le; Hilary C. McCrary; Eugene H. Chang

Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by mutations in the CF transmembrane conductance regulator gene(CFTR) resulting in impaired ion transport. Nearly all people with CF will develop chronic rhino-sinusitis (CRS) and present with the characteristic viscous mucus, impaired mucociliary clearance and chronic inflammation/infection of the sinonasal cavity. While some individuals with CF can appear relatively asymptomatic in terms of their sinus disease, commonly reported symptoms include anosmia, headache, facial pain, nasal obstruction, chronic congestion and nasal discharge. Nasal endoscopy typically reveals mucosal edema, purulent discharge and nasal polyposis. Computed tomography (CT) imaging classically demonstrates the distinguishing findings of sinus hypoplasia or aplasia with generalized opacification, medial bulging of the lateral sinonasal sidewall and a demineralized uncinate process. Current treatment for CF sinusitis includes the use of hypertonic saline, topical and systemic steroids, antibiotics and endoscopic surgery. Research investigating novel therapies designed at targeting the primary defect of CF is showing promise for reversal of CF sinus disease, in addition to potential for disease prevention.


International Forum of Allergy & Rhinology | 2017

Paranasal sinus size is decreased in CFTR heterozygotes with chronic rhinosinusitis

Joshua B. Calton; Pradeep C. Koripella; Amanda L. Willis; Christopher H. Le; Alexander G. Chiu; Eugene H. Chang

Cystic fibrosis (CF) heterozygotes with a single mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are at significantly higher risk to develop chronic rhinosinusitis (CRS). However the reasons why remain unknown. We tested the hypothesis that CFTR heterozygotes would have smaller sinus volumes than healthy controls. To exclude sinus disease as a confounding factor we also assessed paranasal sinus volume in those with CRS, but without known CFTR mutations.


Skull Base Surgery | 2016

Management of Anterior Skull Base Cerebrospinal Fluid Leaks

Christopher H. Le; E. Bradley Strong; Quang Luu

Cerebrospinal fluid (CSF) leak occurs from traumatic, iatrogenic, and idiopathic etiologies. Its timely diagnosis requires clinical, radiographic, and laboratory testing. Medical and surgical management can mitigate the risk of life-threatening infection and morbidity. This article outlines the pathophysiology, diagnosis, and management or CSF leak of the anterior skull base.


Laryngoscope | 2016

Endoscopic resection of maxillary sinus keratocystic odontogenic tumors

Jonnae Y. Barry; Christopher H. Le; Jessica Baumann; Linda Skinker; Alexander G. Chiu; Eugene H. Chang

Keywords: Maxillary sinus keratocystic odontogenic tumors; endoscopic resection; Carnoys solution; maxillary sinus


International Forum of Allergy & Rhinology | 2018

The effect of maxillary sinus antrostomy size on the sinus microbiome: Antrostomy size on the sinus microbiome

Alexander S. Kim; Amanda L. Willis; Daniel Laubitz; Saurabh Sharma; Brian H. Song; Alexander G. Chiu; Christopher H. Le; Eugene H. Chang

The optimal maxillary antrostomy size to surgically treat sinusitis is not well known. In this study, we examined clinical metrics of disease severity and symptom scores, measured secreted inflammatory markers, and characterized the sinus microbiome to determine if there were significant differences in outcome between different maxillary ostial sizes.


International Forum of Allergy & Rhinology | 2018

A prospective, randomized, single-blinded trial for improving health outcomes in rhinology by the use of personalized video recordings: Improving Outcomes in Rhinology with Video Recordings

Saurabh Sharma; Hilary C. McCrary; Erin Romero; Alexander S. Kim; Eugene H. Chang; Christopher H. Le

Clear patient‐physician communication is critical in improving patient compliance, outcomes, and satisfaction. However, constraints of shortened clinic visits, patient anxiety, and poor recall can cause significant barriers to effective communication. We hypothesized that the ability to view patient‐physician counseling videos at home would improve health outcomes.

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