Christopher J. Khor

Changing trends in the proportion of adenocarcinoma of the esophagogastric junction in a large tertiary referral center in Japan

Introduction:  A dramatic increase in incidence of adenocarcinoma of the esophagogastric junction (EGJ) over the past two decades has been reported in the West. However, epidemiological data from Asian countries have not shown a similar trend. The aim of this study was to determine the incidence of adenocarcinoma of the EGJ in a cohort of consecutive patients operated on for gastric adenocarcinoma at a major cancer referral center in Japan.

Racial differences in the prevalence of ulcerative colitis and Crohn's disease in Singapore.

Background : The aim of this study was to determine the prevalence rates of inflammatory bowel disease in the different races in Singapore.

Autoimmune hepatitis in Singapore: a rare syndrome affecting middle-aged women.

Background and Aim: The prevalence of autoimmune hepatitis in Singapore is unknown. Over a period of 7 years, 24 cases were diagnosed in a district general hospital in Singapore (Toa Payoh Hospital) by using the scoring system proposed by the International Autoimmune Hepatitis Group in 1993. The aims of our study were to determine the prevalence of autoimmune hepatitis in Singapore, and to investigate the characteristics and prognosis in the mainly Chinese population.

Diagnosis and treatment of Helicobacter pylori for peptic ulcer bleeding in clinical practice - factors associated with non-diagnosis and non-treatment, and diagnostic yield in various settings

BACKGROUND/AIMS To study the practice of clinicians in the diagnosis and treatment of H. pylori for peptic ulcer bleeding, and the diagnostic yield of H. pylori tests in various situations. MATERIALS AND METHODS All consecutive patients aged ≥18 years who underwent esophagogastroduodenoscopy for the indications of coffee-grounds vomitus, hematemesis or melena with endoscopically diagnosed peptic ulcers were included. RESULTS 374 patients were included. H. pylori testing was performed during acute bleeding for 296 patients. 80% of patients who tested negative for H. pylori during the acute episode were planned for repeat H. pylori testing. 11/88 patients who tested negative for H. pylori during the acute episode were positive for H. pylori during repeat testing (diagnostic yield 12.5%). Prior proton-pump inhibitor and antibiotic ingestion within 4 weeks of presentation was associated with lower diagnostic yield for H. pylori. On multivariate analysis, patients age, systolic blood pressure, heart rate, activated partial thromboplastin time, and need for endoscopic treatment were associated with failure to take biopsies for H. pylori testing during acute episode. 100/106 patients tested positive for H. pylori during the acute episode of gastrointestinal bleeding had H. pylori treatment. CONCLUSION Repeat H. pylori testing after index negative H. pylori testing during acute episodes gave a diagnostic yield of 12.5%, reinforcing the importance of repeat testing.

Mo1993 Identification of Individuals at High Risk of Gastric Cancer for Targeted Endoscopic Screening

Identification of Individuals at High Risk of Gastric Cancer for Targeted Endoscopic Screening Zhu Feng, Li Lin Lim, Calvin J. Koh, David E. Ong, Lee Guan Lim, Khek-Yu Ho, Chia Chung-King, Christopher J. Khor, Choon Jin Ooi, Kwong Ming Fock, Jimmy B. So, Wee Chian Lim, Khoon-Lin Ling, Tiing Leong Ang, Andrew S. Wong, Jaideepraj Rao, Andrea Rajnakova, Ming Teh, Manuel Salto-Tellez, Supriya Srivastava, Yik Ying Teo, Khay Guan Yeoh

Iatrogenic superior mesenteric artery-superior mesenteric vein fistula: an unusual cause of portal hypertension and esophageal variceal bleeding

Iatrogenic superior mesenteric artery-superior mesenteric vein fistula: an unusual cause of portal hypertension and esophageal variceal bleeding